Lactamases PowerPoint PPT Presentations

Title: Title of presentation Author: David Martin Livermore Description: Office 2000 build by www.mediasterling.com Last modified by: PMcCoy Created Date

B ta-lactamases spectre tendu (BLSE) Int r t port aux CTX-M Olivier Vidon Clarisse Bourdin Mars 2005 Historique Fin de la 2 me guerre mondiale ...

ESBL-producing Enterobacteriaceae DiNubile MJ et al. Eur J Clin Microbiol Infect Dis 2005; 24: 443-9. P. aeruginosa resistance DiNubile MJ et al. Eur J Clin ...

How should cephalosporin and penicillin results be reported? ... Tra nh du ng cephalosporin the he 3, aztreonam, hay cefuroxime ...

Plasmids Plasmid genes for antimicrobial resistance often control the formation of enzymes that inactivate the antimicrobial drugs such as -lactamases, ...

Effective against Gm ? rods, Gm , anaerobes; effective against most -lactamases ... Disease caused by Bacillus anthracis, a gram-positive spore-forming bacteria ...

Powerful irreversible inhibitor of b-lactamases - suicide substrate ... Exists as a zwitterion and is soluble in water. Poorly absorbed through the gut wall ...

... 33% non-outbreak Few epidemic strains ... v rare Class D non-metallo-b-lactamases Important in Acinetobacter spp. ESBL Detection: ...

Not themselves mobile, but excise and integrate cassettes that are ... Cassettes for b-lactamases, aminoglycoside resistance, chloramphenicol ...

Loma Linda University Children's Hospital. New trends, aminoglycoside toxicity ... Gram negative bacilli ( GNB) resistant to extended spectrum beta lactamases ...

12 August 2003. AmpC b-Lactamases & their detection. David Livermore ... c. 40,000; alkaline pI. Hydrolytic activity. 1st gen cephs rapid. 2/3 ceph cephs slow ...

... significant side effects including hearing loss and seizures, and are typically ... Best examples are b-lactamases ... A molecular weight under 500 daltons ...

ceph S' ESBL producers. Prospective study of K. pneumoniae ... 2 Baxter & Lambert JAC 1997, 39, 838. MICs (mg/L) for E. cloacae. with metallo-b-lactamases ...

... lactamases (ESBLs) and associated cephalosporin resistance are well established ... plain clavulanic acid and a cephalosporin disc are used, NO increase in ...

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 16 ANTIBACTERIAL AGENTS Part 3: Other lactams Newer b-Lactam Antibiotics Thienamycin (Merck 1976)(from ...

M.D., M.Sc.(Canada), FIMSA, Senior Consultant Physician & Cardio-Metabolic Specialist Purpose of : To discuss the unique mechanism of action of daptomycin.

Swab E. coli ATCC 25922 onto plate to create lawn Place imipenem disk in center. ... Look for growth of E. coli around test isolate streak - indicates ...

... aminoglycoside 3rd ceph.) in Klebsiella pneumoniae in Europe (EARSS) 2005 Risk factors Control of ESBL outbreaks Enzymatic modification Enzymatic ...

Beta-Lactam Antibiotics Clinically Important -Lactam Antibiotics Medicinal Chemistry Presentation David McLeod Southern Methodist University Cephalosporins Unlike ...

NAG. NAG. NAM. NAM. NAM. NAG. NAG. NAM. NAM. NAM. NAG. NAG. Bond formation. inhibited by. penicillin. Cross linking ...

Produced by large scale fermentation (1944) ... Bicyclic system increases b-lactam ring strain. Not much variation in structure is possible ...

... Polar carboxylic acid group is masked by the ester Ester is metabolised in the body by esterases to give the free drug ... Stereochemistry at ... action involves ...

ANTIMICROBIAL RESISTANCE Prof. Khalifa Sifaw Ghenghesh Each class of antimicrobial agent has a unique mode of action. Some antibiotics differ in their action on Gram ...

Nosocomial infections are estimated to double the mortality and morbidity risks ... sodium content therefore can be safely used in patients on salt restricted diets ...

Lecture 7a numbers commercialised

... (Vantin,) Cefteram Ceftibuten (Cedax) Ceftiofur Ceftiolene Ceftizoxime (Cefizox) Ceftriaxone (Rocephin) Classification of Cephalosporin 4.

If you or someone you know has ever had a bacterial infection, you may have heard of Amclav Drops. This medication combines amoxicillin and clavulanic acid and is commonly prescribed for various types of bacterial infections. In this article, we'll examine what Amclav Drops are, how they work, and when they should be used.

Title: Slide 1 Author: lc Last modified by: User Created Date: 2/21/2002 6:48:40 AM Document presentation format: Company: Microsoft Corporation

Detection and Reporting of Beta-lactam Resistance in Enterobacteriaceae ... Adapted from Livermore and Woodford, Trends in Microbiol, 2006. The Gram Negative Cell Wall ...

-LACTAM ANTIBIOTICS THIENAMYCIN MONOBACTAMS -LACTAM INHIBITORS 1. Thienamycin Isolated from Streptomyces cattleya Potent and wide range of activity vs Gram +ve ...

... warfarin, fenito na, carbamazepina ... Infec es odotol gicas e agentes causais mais comuns INFEC O MICROORGANISMOS C rie dental Cocos e bacilos ...

Title: AFBB Sp cialisation Biologie Cellulaire et Mol culaire Cours de g nie microbiologique Author: jfva Last modified by: valogjea Created Date

Title: PowerPoint Presentation Last modified by: EUGENE_SD Created Date: 1/1/1601 12:00:00 AM Document presentation format: Affichage l' cran Other titles

Title: An Overview of Antibiotic Resistance (How Miracle Drugs Created Miracle Bugs) Author: Stephen Brecher Last modified by: Brent Barrett Created Date

Polar due to the side chain - difficult to isolate and purify ... Exists as a zwitterion and is soluble in water. Poorly absorbed through the gut wall ...

NAMA, N-acetyl-muramic acid; NAGA, N-acetyl-glucosamine. ... a new subunit of N-acetylmuramic acid (NAMA) and N-acetylglucosamine (NAGA) ...

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 16 ANTIBACTERIAL AGENTS Part 2: Cephalosporins CEPHALOSPORINS 1. Introduction Antibacterial agents which ...

MECHANISMS OF ACTION OF ANTIBIOTICS BACTERIOSTATIC AGENTS Sulfonamides Drugs inhibiting protein synthesis except aminoglycosides (macrolides, chloramphenicol ...

Altered antibiotic target/Overproduction of target. Reduced ... Inherent features of the bacterial species which prevent antibiotic action. Usually expressed ...

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 16 ANTIBACTERIAL AGENTS Part 2: Cephalosporins CEPHALOSPORINS 1. Introduction Antibacterial agents which ...

MDRO(multidrug resistant organisms) Definition microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents.

Reduce unnecessary antibiotic utilisation (& reduce unnecessary adverse effects too) ... B. Reduce Unnecessary Antibiotic Utilisation To Decrease Selective Pressure ...

Title: PowerPoint Presentation Author: karlm Last modified by: Emaneini Created Date: 11/25/2002 2:35:13 AM Document presentation format: On-screen Show (4:3)

The PDB is a resource which compiles essential information about many proteins. ... We'll be investigating -lactamase. Type PC1 into the search box. ...

CLINICAL PHARMACOLOGY OF ANTIBACTERIAL AND ANTIVIRAL AGENTS ANTIBACTERIAL DRUGS. Mechanisms of Action 1. Inhibition of bacterial cell wall synthesis or activation of ...

prolonged hospitalization, ICU stay, invasive devices, immunosuppression, and ... In South America, large dissemination of KPC was initially reported in K ...

The isolate is resistant to imipenem (IPM 10) ceftazidime (CAZ 10) ... (CTX 5), cefotetan (CTT 30), Augmentin (AMC 60), and susceptible to aztreonam (ATM 30) ...

Title: ATB-G n ralit s Subject: ATB-G n ralit s Author: Sylvestre Tigaud & Jacqueline Grando Keywords: Antibiotique G n ralit Last modified by

Antimicrobial Prophylaxis in Surgery To prevent wound infection during or after surgical procedures. Factors responsible for wound infection Critical number of ...

Development of Resistance mechanisms in Pseudomonas aeruginosa. Luis Mart nez Mart nez ... Perron et al, JBC 2004 (Mod.) czcS. czcA. czcB. czcC. czcCBA. czcR. oprD ...

TRATAMIENTO DE INFECCIONES GRAVES POR G RMENES PRODUCTORES DE BLEE Carmen Blanco UCI del H.Son Dureta Las infecciones causadas por BGN productores de BLEE pueden ser ...

Modest activity against Staphylococcus aureus Gram-negative bacteria Escherichia coli, Klebsiella pneumoniae, Proteus spp. Haemophilus influenzae, Neisseria spp.

1970-1980s: strong -lactam agents for S.aureus, emergence of MRSA ... Susceptible to PCN G, Ampicillin, Piperacillin, Vancomycin ...

Sterilization (or sterilisation) refers to any process that eliminates, removes, kills, or deactivates all forms of life and other biological agents (such as fungi, bacteria, viruses, spore forms, prions, unicellular eukaryotic organisms such as Plasmodium, etc.) present in a specified region, such as a surface, a volume of fluid, medication, or in a compound such as biological culture media. Sterilization can be achieved through various means, including: heat, chemicals, irradiation, high pressure, and filtration. Sterilization is distinct from disinfection, sanitization, and pasteurization, in that sterilization kills, deactivates, or eliminates all forms of life and other biological agents which are present.

Chapter 8 Antibiotics Section 1. Lactam Antibiotics(2) Wei-Min Chen, Prof. Department of Medicinal Chemistry, JNU Topics in This Class Cephalosporins Non-typical ...

Bacterial Cell Wall Inhibitors -lactam antibiotics Contain a beta-lactam ring that is part of their chemical structure An intact beta-lactam ring is ...