Maraviroc PowerPoint PPT Presentations

Maraviroc, as a switch option, in HIV-1 infected individuals with stable, well-controlled HIV replication and R5-tropic virus on their first N(t)RTI+PI/r regimen. Week 48 results of the randomised, multicentre MARaviroc switCH study (MARCH)

https://www.genuinedrugs123.com/149-Anti-HIV-Aids-Drugs-Generic-Maraviroc-Brand-Selzentry.aspx - Maraviroc is a medication used for treating HIV infection. It belongs to a class of drugs called CCR5 antagonists, which prevent the virus from entering immune cells. Maraviroc is prescribed in combination with other antiretroviral drugs to control the spread of HIV and reduce the risk of disease progression.

Understand the role and importance of the Trofile assay in relation to CCR5 ... Vicriviroc- Not FDA approved, in clinical trials, same MOA as maraviroc. ...

Genotypic susceptibility scores (GSS) and phenotypic susceptibility scores (PSS) ... EC50 FC values 2-fold within the normal range of the Monogram assay (0.32-1.95) ...

The Role of Maraviroc in Antiretroviral Therapy for Treatment-Experienced Patients ... Brigham and Women's Hospital. Harvard Medical School ...

The MERIT Study of Maraviroc in Antiretroviral-Naive Patients With R5 ... Lobar pneumonia/lower respiratory tract infection. MVC CBV. N=360. EFV CBV. N=361 ...

Rationale for Studying MARAVIROC in Patients with Dual/Mixed (D/M)-Tropic Infections. Theoretical risk of outgrowth of X4-tropic HIV-1 when a patient with ...

Median Viral load 40 copies/mL. Median CD4 count 565 cells/ l ... susceptible = 1; hypersusceptibility = 1.33. median. median. median. PZB Aachen. Thanks to: ...

Changes in HIV-1 Co-receptor Tropism for Patients Participating in the Maraviroc MOTIVATE 1 and 2 Clinical Trials E van der Ryst and M Westby Pfizer Global Research ...

within 28 days, date of death not captured in database ... Median Maximum Change in Fasting Lipids. Total. cholesterol. HDL cholesterol. LDL cholesterol ...

Virological Correlates Associated with Treatment Failure at Week 48 in the Phase 3 Study of Maraviroc in Treatment-Naive Patients Jayvant Heera1, Mike Saag2, Prudence ...

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... Entry inhibitors Enfuvirtide (fusion inhibitor); Maraviroc (CCR5 receptor antagonist); Drugs for Viral Hepatitis Interferons , , ...

lorsque CD4 350/mm3 : risques plus faibles d' chec virologique et de ... Tous bras/doses de raltegravir confondus. Etude MERIT : maraviroc chez des patients na fs ...

If he has R5/X4 (D/M) tropic virus, would you use maraviroc? Yes. No. It ... 1029: Virologic and Immunologic Outcomes Vs. OBT at 24 Weeks FAS, Dual/Mixed Tropic ...

Antiretroviral Armamentarium: Novel Agents in Clinical Development. Entry inhibitors ... Antiretroviral Armamentarium: CCR5 coreceptor antagonist ...

Traiter le virus (ARV), obtenir une ind tectabilit assez longtemps pour r duire le ... STRATEGIES ACTUELLES. 2 puis n ligne: selon g notype si chappement, selon tol rance si ...

... (Cmin) Virologic Success (RNA 400 copies/mL) Analysis. Review team. Pravin Jadhav Jenny Zheng. Shashi Amur Kellie Reynolds. Joga Gobburu John Lazor ...

HIV

T-20 Resistance T-20 - first entry inhibitor - sc injection, ... New Treatments DRUG COMPANY CLASS ABS no Tipranavir Boehringer PI 104, ...

Speakers Bureau: Pfizer. Research Support: Tibotec, GlaxoSmithKline, Bristol-Myers-Squibb ... This set has been peer-reviewed to ensure that there are ...

Viral tropism = the way the virus responds to external stimulus in order to ... Viral tropism. Balance of an HIV infection can be mixed between X4 and R5 and ...

For purposes of discussion, we will assume that each of the ... Goes on a hunting trip with Dick Cheney! Case 5. 32 yo woman diagnosed with HIV 4 years ago ...

CD4 213 cells/mm in 2000. Very reluctant to start ARVs ... Shown prospectively to reliably guide the use of CCR5 antagonists in patients with R5 results ...

At present, anti-HIV drugs are aimed at two targets: reverse transcriptase and HIV protease. ... Nucleoside/Nucleotide Reverse Transcriptase Inhibitors ...

NRTIs are sometimes called the

Lipitor, Norvasc, Zoloft, Celebrex, Xalatan, Viagra. Consumer Healthcare ... Lost patent suit to Chinese Viagra. Barr launched generic Zoloft ...

Penetration of reservoirs. Acquired and transmitted drug resistance. Cross resistance. Convenience/tolerability (particularly for second or third line regimens) ...

Faciliter la prise en charge des nouveaux patients. Assurer des consultations d' ducation ... Assurer la coordination de l' quipe pluridisciplinaire. Groupe d'Aide ...

Actualizaci n sobre interacciones farmacol gicas del tratamiento antirretroviral www.interaccionesHIV.com Montse Tuset mtuset@clinic.ub.es Servicio de Farmacia

Issues from CROI relating to new treatment. How to stay up to date ... may have 20-30 new targets and compounds discussed in pre-clinical and in ...

Between '87 and '95, 4 antiretrovials were launched. Since '95, 24 new products have been introduced. 25 years of ... Common ADR: diarrhea, rash, ISR, pyrexia ...

Activity: Requires R5-tropic HIV & Screening with HIV Tropism Assay ... HIV-infected: R5-tropic - Treatment Experienced - HIV RNA 5,000 copies/ml ...

4. Therapeutic index (T.I.) Minimum dose toxic to cell. Minimum dose toxic to virus ... DNA chain terminator. DNA polymerase inhibitor ...

1: Pediatr Infect Dis J. 2006 Nov;25(11):1044-8. ... J Infect 2002;44:194-195. ... 13th Conference on Retroviruses and Opportunistic Infections. Denver, Colorado, USA. ...

HIV:HCV Co-infection Landscape 21 of October, 09 Madrid,Spain GESIDA, Madrid HCV Protease Inhibitor R7227 HCV Protease Inhibitors Telaprevir and Boceprevir protease ...

... (Belgium), Van Laethem Kristel (Belgium), Verhofstede Chris (Belgium), Walter Hauke (Germany), Wensing Annemarie (the Netherlands), Yerly Sabine (Suisse ...

Novel NNRTI designed to have a high genetic barrier to ... Diarrhea, nausea, fatigue, ISRs, headache, pruritus. Occurring in 5% of 2 patients per arm ...

Professor of Medicine, David Geffen School of Medicine at UCLA ... tubulointerstitial nephritis with medullary calcification and cortical atrophy ...

More than 75% of women receiving Nevirapine develop a major resistance mutation ... Requires dosing very precisely every eight hours in order to thwart drug ...

... http://wwwaidsinfo.nih.gov. Initiating Antiretroviral Therapy. Acute ... TDF FTC EFV versus ZDV 3TC EFV. Study GS934. Patients (N = 517 randomized) ...

Prospettive della farmacogenetica e della farmacogenomica. Stefano Vella ... Except for monozygotic twins, each person's genome is unique. ...

Classes of Antiretroviral drugs Entry inhibitors interfere with binding, fusion and entry of HIV-1 to the host cell by blocking one of several targets.

Interpretaci n Cl nica del Genotipo y Manejo del Paciente con Experiencia Previa ... Acumulaci n gradual de TAMs en condones 41, 67, 70, 210, 215, and 219. ...

0. Pfizer Global Research. Development. Where do drugs come ... Viagra. Celebrex/Celebra. Dynastat. Source: Pfizer 2002 Year-End Corporate Earnings Release ...

Potential targets for prevention. Possible classes of ... 14 days. 7 days. p24 Ag. HIV-1. infection 2h. wash step. 30 min. or. Cell-free virus. Compound ...

Boosted protease inhibitors have 60% lower risk of resistance compared with ... Ritonavir boosted regimens are widely used but the best results are usually ...

Clinical Director, Northwest AIDS Education and Training Center ... 4. Valacyclovir (Valtrex) DHS/HIV/PP. DHS/HBV/PP. FDA-Approved Therapies for HBV Infection ...

What is your goal for using ART in late antiretroviral failure? ... Review ART history. Assess adherence, tolerability, and PK ...

Identification of resistance mutations may optimize treatment outcomes ... High pill burden/ Dosing inconvenience. www.aidsetc.org. Should Not Be Offered at Any Time ...

Breast Cancer. Recurrence Risk. BCR-ABL (Ph ) C-kit GIST. Gleevec. Chronic ... Risk of finding susceptibility to an incurable disease (e.g. Huntington's) ...

International AIDS Society USA ... ATV. FTC. FPV. TPV. DRV. ETR. RAL MVC. Slide 3 ... do NOT use with other NNRTI, unboosted PI, ATV/r, FPV/r, TPV/r, RIF, antiseizure ...

(at least from the inf dis epidemiologist point of view) ... Combine with treatment of drug dependancy. Beware of the resistance! Thank You! ...

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Plan for Success, but Prepare for Failure - Prove that primary drug resistance ... with recent infection and in newly diagnosed with unknown time of infection ...

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