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Overview of the OATP family PowerPoint PPT Presentation
Overview of the OATP family - Rat. Human. OATP1B1. OATP1B3. OATP2B1. Hepatocyte ... Rat. Human. Function. Substrates tend to be amphipathic molecules with high molecular weight ( 450) ...
Rat. Human. OATP1B1. OATP1B3. OATP2B1. Hepatocyte ... Rat. Human. Function. Substrates tend to be amphipathic molecules with high molecular weight ( 450) ...
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Organic Ion Transporters PowerPoint PPT Presentation
Organic Ion Transporters - There are a variety of transporters and they are classified into ... Uptake of Troglitazone Sulfate by Xenopus Oocytes Expressed with OATP-C, OATP8 and OATP-B ...
There are a variety of transporters and they are classified into ... Uptake of Troglitazone Sulfate by Xenopus Oocytes Expressed with OATP-C, OATP8 and OATP-B ...
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Dr' Mine Yarim September' 2002 PowerPoint PPT Presentation
Dr' Mine Yarim September' 2002 - Organic anion transporting polypeptides (Oatps/OATPs) Organic cation transporters (OCTs) Organic anion ... 8.8 Madin-Darby Canine Kidney [4] Glycocholate ...
Organic anion transporting polypeptides (Oatps/OATPs) Organic cation transporters (OCTs) Organic anion ... 8.8 Madin-Darby Canine Kidney [4] Glycocholate ...
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Isolated Perfused Livers: PowerPoint PPT Presentation
Isolated Perfused Livers: - Effect of Estradiol 17 beta-D glucuronide, Rifampicin and a new ... GS-Xenobiotic. Bilirubin. Mrp 2. OATP. B-UGT 1. Glu-Bilirubin. CYTOKINES. PgP. SEPSIS. eff: ...
Effect of Estradiol 17 beta-D glucuronide, Rifampicin and a new ... GS-Xenobiotic. Bilirubin. Mrp 2. OATP. B-UGT 1. Glu-Bilirubin. CYTOKINES. PgP. SEPSIS. eff: ...
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Transporters: Focus on OATP1B1 and Selected Renal Transporters PowerPoint PPT Presentation
Transporters: Focus on OATP1B1 and Selected Renal Transporters - OATP1B1: benzylpenicillin, atorvastatin,cerivastatin, fluvastatin, pitavastatin, ... MATE -1. Expression of Various Renal Transporters in Human Kidney ...
OATP1B1: benzylpenicillin, atorvastatin,cerivastatin, fluvastatin, pitavastatin, ... MATE -1. Expression of Various Renal Transporters in Human Kidney ...
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DRUG-DRUG INTERACTIONS PowerPoint PPT Presentation
DRUG-DRUG INTERACTIONS - ... and CYPs OATP1B1 4.5 Pitavastatin CYP3A4/OATP1B1 7.0 Atorvastatin OATP1B1 8.0 Pravastatin CYP3A4 8.0 Simvastatin Presumed Mechanism AUC or Cmax Increase In ...
... and CYPs OATP1B1 4.5 Pitavastatin CYP3A4/OATP1B1 7.0 Atorvastatin OATP1B1 8.0 Pravastatin CYP3A4 8.0 Simvastatin Presumed Mechanism AUC or Cmax Increase In ...
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An Integrated Approach to Identify Drug Transporters Involved in a Compounds Disposition During Prec PowerPoint PPT Presentation
An Integrated Approach to Identify Drug Transporters Involved in a Compounds Disposition During Prec - The Challenge of Drug Transporters in ADME. Studies and Tools ... Angela Mote. Kevin D. Read. Larry Shampine. Giovanni Vitulli. Lindsey Webster. Joe Woolley ...
The Challenge of Drug Transporters in ADME. Studies and Tools ... Angela Mote. Kevin D. Read. Larry Shampine. Giovanni Vitulli. Lindsey Webster. Joe Woolley ...
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BI Experience/Opinion: Transporter Based Drug Interactions PowerPoint PPT Presentation
BI Experience/Opinion: Transporter Based Drug Interactions - In Vitro Techniques and Data. Reports: Clinical Transporter-Based ... Laboratory Work Transporter Group: Lalitha Podila. Diane Ely. Rucha Sane. Susan Lazos ...
In Vitro Techniques and Data. Reports: Clinical Transporter-Based ... Laboratory Work Transporter Group: Lalitha Podila. Diane Ely. Rucha Sane. Susan Lazos ...
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P glycoproteins - Drug interactions PowerPoint PPT Presentation
P glycoproteins - Drug interactions - The substrates, inducers and inhibitors of P glycoproteins are dealt in this presentation.
The substrates, inducers and inhibitors of P glycoproteins are dealt in this presentation.
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Chrysanthemum parthenium (L.) Berhn (feverfew) ???, ??? PowerPoint PPT Presentation
Chrysanthemum parthenium (L.) Berhn (feverfew) ???, ??? - Chrysanthemum parthenium (L.) Berhn (feverfew) , Aristolochia fangchi ( ) as anti-inflammatory, contains aristolochic acid (AA ...
Chrysanthemum parthenium (L.) Berhn (feverfew) , Aristolochia fangchi ( ) as anti-inflammatory, contains aristolochic acid (AA ...
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Overview of Drug Transporter Families and Their Importance in ADME PowerPoint PPT Presentation
Overview of Drug Transporter Families and Their Importance in ADME - ... organic anion transportings. SLC22: The organic cation/anion/zwitterion transporters ... Driving mechanism = anion exchange. Bicarbonate, GSH, GSH-conjugates ...
... organic anion transportings. SLC22: The organic cation/anion/zwitterion transporters ... Driving mechanism = anion exchange. Bicarbonate, GSH, GSH-conjugates ...
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Hiperbilirrubinemias Hereditarias PowerPoint PPT Presentation
Hiperbilirrubinemias Hereditarias - ICTERICIA la producci n de pigmentos biliares Hay una falla hep tica para conjugar y excretar pigmentos biliares Excreci n de pigmentos debido a ...
ICTERICIA la producci n de pigmentos biliares Hay una falla hep tica para conjugar y excretar pigmentos biliares Excreci n de pigmentos debido a ...
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Evaluation of Hepatotoxic Potential of Drugs Using Transporterbased Assays PowerPoint PPT Presentation
Evaluation of Hepatotoxic Potential of Drugs Using Transporterbased Assays - Transporters involved in hepatic CL may determine systemic ... Gelled Collagen Plates. Rat Hepatocytes in Primary Culture. 0. 2. 4. 6. 8. 10. 12. 14. 16. 18 ...
Transporters involved in hepatic CL may determine systemic ... Gelled Collagen Plates. Rat Hepatocytes in Primary Culture. 0. 2. 4. 6. 8. 10. 12. 14. 16. 18 ...
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Managing Drug Interactions in the Patient with Aspergillosis PowerPoint PPT Presentation
Managing Drug Interactions in the Patient with Aspergillosis - the Patient with Aspergillosis Russell E. Lewis, Pharm.D., FCCP Associate Professor University of Houston College of Pharmacy/ The University of Texas M.D. Anderson ...
the Patient with Aspergillosis Russell E. Lewis, Pharm.D., FCCP Associate Professor University of Houston College of Pharmacy/ The University of Texas M.D. Anderson ...
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Diapositive 1 PowerPoint PPT Presentation
Diapositive 1 - Variabilit dans la r ponse aux m dicaments li e la r sorption Pr Isabelle Macquin-Mavier R sorption du c liprolol et jus d orange celiprolol jus ...
Variabilit dans la r ponse aux m dicaments li e la r sorption Pr Isabelle Macquin-Mavier R sorption du c liprolol et jus d orange celiprolol jus ...
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Transporte de solutos y agua PowerPoint PPT Presentation
Transporte de solutos y agua - ... Capacidad de concentraci n para la glucosa con el SGLT2: 1 Na+: 1 glucosa PowerPoint Presentation PowerPoint Presentation Intercambiadores (antiporters) ...
... Capacidad de concentraci n para la glucosa con el SGLT2: 1 Na+: 1 glucosa PowerPoint Presentation PowerPoint Presentation Intercambiadores (antiporters) ...
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Pharmacotherapy of antifungal drugs PowerPoint PPT Presentation
Pharmacotherapy of antifungal drugs - Pharmacotherapy of antifungal drugs. Isabel Spriet. Pharmacy Dpt, UZ Leuven. The ... depolarisation: leakage of monovalent and divalent cations. cell death ...
Pharmacotherapy of antifungal drugs. Isabel Spriet. Pharmacy Dpt, UZ Leuven. The ... depolarisation: leakage of monovalent and divalent cations. cell death ...
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PHASE 3: Transporterbased DDIs 101 PowerPoint PPT Presentation
PHASE 3: Transporterbased DDIs 101 - PHASE 3: Transporterbased DDIs 101
PHASE 3: Transporterbased DDIs 101
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Pharmacogenetics: What is it How do I measure it What does it mean to me PowerPoint PPT Presentation
Pharmacogenetics: What is it How do I measure it What does it mean to me - Metoprolol Exposure with Equal Weight Doses-Reduced Metabolism in Asians. 10 EMs (Caucs) and 6 PMs (Asians) took metoprolol daily for 5 days ...
Metoprolol Exposure with Equal Weight Doses-Reduced Metabolism in Asians. 10 EMs (Caucs) and 6 PMs (Asians) took metoprolol daily for 5 days ...
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Role of mechanistic transport studies in lead optimization' PowerPoint PPT Presentation
Role of mechanistic transport studies in lead optimization' - L-mdr1a- LLC PK-1 cells expressing mouse P-glycoprotein. In vivo models: CF-1 -/- and / mice ... Mouse. Human. L-mdr1a. L-MDR1. CF-1 /-- mice ...
L-mdr1a- LLC PK-1 cells expressing mouse P-glycoprotein. In vivo models: CF-1 -/- and / mice ... Mouse. Human. L-mdr1a. L-MDR1. CF-1 /-- mice ...
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Why Highly Variable Drugs are Safer PowerPoint PPT Presentation
Why Highly Variable Drugs are Safer - Why Highly Variable Drugs are Safer. Leslie Z. Benet, Ph.D. ... Black numbers (Benet, Transplant. Proc. 31: 1642-44. 1999) ( T - R)2 ...
Why Highly Variable Drugs are Safer. Leslie Z. Benet, Ph.D. ... Black numbers (Benet, Transplant. Proc. 31: 1642-44. 1999) ( T - R)2 ...
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RECOVERY OPPORTUNITY FOR SYSTEM CHANGE: WHY, HOW AND FOR WHOM PowerPoint PPT Presentation
RECOVERY OPPORTUNITY FOR SYSTEM CHANGE: WHY, HOW AND FOR WHOM - Recovery House 69% Connect to care vs. 36% without Recovery House stay ... sober' 'Having same rights as others' 'Doing. everyday things' 'Getting well ...
Recovery House 69% Connect to care vs. 36% without Recovery House stay ... sober' 'Having same rights as others' 'Doing. everyday things' 'Getting well ...
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Grapefruit Drug Interaction: Isolation, Biological Activities of Furocoumarins and Their Variation d PowerPoint PPT Presentation
Grapefruit Drug Interaction: Isolation, Biological Activities of Furocoumarins and Their Variation d - Grapefruit Drug Interaction: Isolation, Biological Activities of Furocoumarins and Their Variation d
Grapefruit Drug Interaction: Isolation, Biological Activities of Furocoumarins and Their Variation d
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LC-MS Determination of Bile Acid-Sulfates As Biomarkers for Liver Function PowerPoint PPT Presentation
LC-MS Determination of Bile Acid-Sulfates As Biomarkers for Liver Function - 48.66 4866.40 4.87 89.00 256.98 25698.30 25.70 90.00 298.47 29846.80 29.85 91.00 238.75 23874.80 23.87 92.00 177.34 17733.70 17.73 93.00 116.78 11677.80 11.68 94.00 ...
48.66 4866.40 4.87 89.00 256.98 25698.30 25.70 90.00 298.47 29846.80 29.85 91.00 238.75 23874.80 23.87 92.00 177.34 17733.70 17.73 93.00 116.78 11677.80 11.68 94.00 ...
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Pharmakologie der HAART im zentralen Nervensystem PowerPoint PPT Presentation
Pharmakologie der HAART im zentralen Nervensystem - Pharmakologie der HAART im zentralen Nervensystem PD Dr. med. Nils von Hentig HIVCENTER, Medizinische Klinik II Klinikum der Johann Wolfgang Goethe-Universit t ...
Pharmakologie der HAART im zentralen Nervensystem PD Dr. med. Nils von Hentig HIVCENTER, Medizinische Klinik II Klinikum der Johann Wolfgang Goethe-Universit t ...
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Clinical Pharmacology Subcommittee (CPSC) Report ACPS Presentation, May 3, 2005 J PowerPoint PPT Presentation
Clinical Pharmacology Subcommittee (CPSC) Report ACPS Presentation, May 3, 2005 J - To provide expertise and feedback to ACPS, specifically in the ... in Drug Development (Empiricism versus Mechanistic Approaches, Frequentists versus Bayesians) ...
To provide expertise and feedback to ACPS, specifically in the ... in Drug Development (Empiricism versus Mechanistic Approaches, Frequentists versus Bayesians) ...
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Dr Allister Grant MRCP, PhD PowerPoint PPT Presentation
Dr Allister Grant MRCP, PhD - Aberrant Lymphocyte Homing. Cytokines. AETIOLOGY OF PSC? HLA polymorphisms ... Aberrant Lymphocyte Homing. AETIOLOGY OF PSC? Transmigration. Tethering Rolling ...
Aberrant Lymphocyte Homing. Cytokines. AETIOLOGY OF PSC? HLA polymorphisms ... Aberrant Lymphocyte Homing. AETIOLOGY OF PSC? Transmigration. Tethering Rolling ...
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OLAP IN THE DATA WAREHOUSE PowerPoint PPT Presentation
OLAP IN THE DATA WAREHOUSE - Now consider information retrieval and manipulation in these environments ... each user to build a custom datacube may cause a lack of data consistency among users. ...
Now consider information retrieval and manipulation in these environments ... each user to build a custom datacube may cause a lack of data consistency among users. ...
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Dr Allister Grant MRCP, PhD PowerPoint PPT Presentation
Dr Allister Grant MRCP, PhD - Anything New in PSC? Dr Allister Grant MRCP, PhD Consultant Hepatologist Leicester Royal Infirmary Investigation Dilated intrahepatic ducts on USS/ tumour compression ...
Anything New in PSC? Dr Allister Grant MRCP, PhD Consultant Hepatologist Leicester Royal Infirmary Investigation Dilated intrahepatic ducts on USS/ tumour compression ...
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Drug Interactions Clinical Pharmacology Spring Course 2006 PowerPoint PPT Presentation
Drug Interactions Clinical Pharmacology Spring Course 2006 - Pharmacokinetic: Elimination ... benzodiazeines- diazepam, midazolam; cyclosporine, tacrolimus,; HIV Protease Inhibitors indinavir, ritonavir; chlorpheniramine; ...
Pharmacokinetic: Elimination ... benzodiazeines- diazepam, midazolam; cyclosporine, tacrolimus,; HIV Protease Inhibitors indinavir, ritonavir; chlorpheniramine; ...
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THE BILIARY TREE AND CHOLESTASIS PowerPoint PPT Presentation
THE BILIARY TREE AND CHOLESTASIS - Enlargement of the bile canaliculi is limited by a 'corset' of actin microfilaments. ... possibly disrupting the actin corset around the bile canaliculus ...
Enlargement of the bile canaliculi is limited by a 'corset' of actin microfilaments. ... possibly disrupting the actin corset around the bile canaliculus ...
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Chapter%208%20(Part%20C) PowerPoint PPT Presentation
Chapter%208%20(Part%20C) - Core requirement of building a realistic' business model. ... Red Brick Systems was first to implement many essential OLAP functions (as ...
Core requirement of building a realistic' business model. ... Red Brick Systems was first to implement many essential OLAP functions (as ...
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Physiologie de la thyrode PowerPoint PPT Presentation
Physiologie de la thyrode - Hypothyro die adulte:=somnolence ralentissement. 2.1 Effets tissulaire des hormones ... TSH adulte: r sistance axe hypothalamo hypophysaire la T4 ...
Hypothyro die adulte:=somnolence ralentissement. 2.1 Effets tissulaire des hormones ... TSH adulte: r sistance axe hypothalamo hypophysaire la T4 ...
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ACPS-CPSC meeting, Nov 3 pm session PowerPoint PPT Presentation
ACPS-CPSC meeting, Nov 3 pm session - In Vitro and In Vivo Drug-Drug Interaction Concept Paper: ... in vivo data, then a clinical study with a P-gp ... recommend any in vivo studies with substrates ...
In Vitro and In Vivo Drug-Drug Interaction Concept Paper: ... in vivo data, then a clinical study with a P-gp ... recommend any in vivo studies with substrates ...
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