P53 PowerPoint PPT Presentations

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???????????????????????p53(??????? PowerPoint PPT Presentation
???????????????????????p53(??????? - Title: Author: Masaru Wada Last modified by: Masaru Wada Created Date: 11/12/1997 5:26:32 AM Document presentation format
Title: Author: Masaru Wada Last modified by: Masaru Wada Created Date: 11/12/1997 5:26:32 AM Document presentation format
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Post-transcriptional modifications of p53 PowerPoint PPT Presentation
Post-transcriptional modifications of p53 - ... O-GlcNAcylation of p53 by STZ treatment inhibits phosphorylation of p53 at Thr 155 in MCF-7 cells p53 is modified by O-GlcNAc at Ser 149 Mutation of the p53 O ...
... O-GlcNAcylation of p53 by STZ treatment inhibits phosphorylation of p53 at Thr 155 in MCF-7 cells p53 is modified by O-GlcNAc at Ser 149 Mutation of the p53 O ...
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Copy the following chart onto Portfolio p53 PowerPoint PPT Presentation
Copy the following chart onto Portfolio p53 - Why did the Mormons move west? ... hundreds of traders and settlers were making the 800-mile journey along the Santa Fe Trail from Missouri to New Mexico each year.
Why did the Mormons move west? ... hundreds of traders and settlers were making the 800-mile journey along the Santa Fe Trail from Missouri to New Mexico each year.
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The p53 Signaling Pathway PowerPoint PPT Presentation
The p53 Signaling Pathway - The tumor-suppressor protein p53 exhibits sequence-specific DNA-binding, ... Jimenez, G.S., et al., p53 regulation by post-translational modification and ...
The tumor-suppressor protein p53 exhibits sequence-specific DNA-binding, ... Jimenez, G.S., et al., p53 regulation by post-translational modification and ...
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ATM/p53 Signaling Pathway PowerPoint PPT Presentation
ATM/p53 Signaling Pathway - The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts ... The critical role of p53 is evident by the fact that it is mutated in over 50 ...
The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts ... The critical role of p53 is evident by the fact that it is mutated in over 50 ...
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p53 guardian or the genome PowerPoint PPT Presentation
p53 guardian or the genome - ... the product of the ATM gene that is lost in pasients with ataxia-telangiectasia ... ATM gene product (name from ataxia-telangiectasia; a kinase) p53 becomes ...
... the product of the ATM gene that is lost in pasients with ataxia-telangiectasia ... ATM gene product (name from ataxia-telangiectasia; a kinase) p53 becomes ...
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p53 and Control of the Cell Cycle PowerPoint PPT Presentation
p53 and Control of the Cell Cycle - p53 and Control of the Cell Cycle * Learning Objectives Recall the functions of Mdm2 and p53 and how the regulation of each affects apoptosis and cell cycle arrest ...
p53 and Control of the Cell Cycle * Learning Objectives Recall the functions of Mdm2 and p53 and how the regulation of each affects apoptosis and cell cycle arrest ...
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p53 guardian or the genome PowerPoint PPT Presentation
p53 guardian or the genome - 393 aa with 4-5 functional domains. biological role as watch dog - 'vaktbikkje' ... conserved family identified in silencing in yeast. function as NAD-dep deacetylase ...
393 aa with 4-5 functional domains. biological role as watch dog - 'vaktbikkje' ... conserved family identified in silencing in yeast. function as NAD-dep deacetylase ...
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Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100 PowerPoint PPT Presentation
Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100 - Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
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Wie kontrolliert p53 die genom' Stabilitt PowerPoint PPT Presentation
Wie kontrolliert p53 die genom' Stabilitt - Importance of double-strand breaks ... XRCC-4 (XR-1 mutant of CHO) @Ch5. cloned and corrects dsbr and VDJ ... p53 protein plays a major role in cancer risk ...
Importance of double-strand breaks ... XRCC-4 (XR-1 mutant of CHO) @Ch5. cloned and corrects dsbr and VDJ ... p53 protein plays a major role in cancer risk ...
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Replication, P53 Gene, Histones, Cell Cycle, and Cancer PowerPoint PPT Presentation
Replication, P53 Gene, Histones, Cell Cycle, and Cancer - Replication, P53 Gene, Histones, Cell Cycle, and Cancer Robert F. Waters, Ph.D. Cell Cycle and Histones Chromosomes Nucleosome Contains a nucleosome core particle 146 ...
Replication, P53 Gene, Histones, Cell Cycle, and Cancer Robert F. Waters, Ph.D. Cell Cycle and Histones Chromosomes Nucleosome Contains a nucleosome core particle 146 ...
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Resveratrol or caffeine induce. p53 Ser 15 phosphorylation PowerPoint PPT Presentation
Resveratrol or caffeine induce. p53 Ser 15 phosphorylation - Resveratrol or caffeine induce. p53 Ser 15 phosphorylation. Resveratrol. EGCG. Caffeine. Theaflavins. POST-TRANSLATIONAL. MODIFICATION OF P53 IN TUMORIGENESIS ...
Resveratrol or caffeine induce. p53 Ser 15 phosphorylation. Resveratrol. EGCG. Caffeine. Theaflavins. POST-TRANSLATIONAL. MODIFICATION OF P53 IN TUMORIGENESIS ...
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The regulation of p53 dynamics in response to DNA damage PowerPoint PPT Presentation
The regulation of p53 dynamics in response to DNA damage - The regulation of p53 dynamics in response to DNA damage ... Wip1 identified as the putative inhibtor. Inhibitor should initially be at relatively low levels ...
The regulation of p53 dynamics in response to DNA damage ... Wip1 identified as the putative inhibtor. Inhibitor should initially be at relatively low levels ...
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P53 Pathway Reconstruction Through Integration of Microarray Data PowerPoint PPT Presentation
P53 Pathway Reconstruction Through Integration of Microarray Data - Functional annotation and network reconstruction through cross-platform ... signaling pathways induced by nitric oxide in human lymphoblastoid cells ...
Functional annotation and network reconstruction through cross-platform ... signaling pathways induced by nitric oxide in human lymphoblastoid cells ...
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Oscillating Gene Expressions in Feed-back Networks: Basics and applications to p53, Hes1 and NF-?B. PowerPoint PPT Presentation
Oscillating Gene Expressions in Feed-back Networks: Basics and applications to p53, Hes1 and NF-?B. - Oscillating Gene Expressions in Feedback Networks: Basics and applications to p53, Hes1 and NFB'
Oscillating Gene Expressions in Feedback Networks: Basics and applications to p53, Hes1 and NFB'
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Absence of RCA Isolated from Patients Treated with INGN 201 (Ad5CMV-p53) PowerPoint PPT Presentation
Absence of RCA Isolated from Patients Treated with INGN 201 (Ad5CMV-p53) - Title: Melanoma Differentiation-Associated-7 (mda-7) gene Author: Mhashilkar Last modified by: OHRMS Created Date: 11/3/1998 7:46:32 PM Document presentation format
Title: Melanoma Differentiation-Associated-7 (mda-7) gene Author: Mhashilkar Last modified by: OHRMS Created Date: 11/3/1998 7:46:32 PM Document presentation format
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Preirradiation at a lowdoserate blunted tumor suppressor p53 response PowerPoint PPT Presentation
Preirradiation at a lowdoserate blunted tumor suppressor p53 response - Pre-irradiation at a low-dose-rate blunted tumor suppressor p53 response ... To estimate the effects of space radiation on health ... coloring. TUNEL staining ...
Pre-irradiation at a low-dose-rate blunted tumor suppressor p53 response ... To estimate the effects of space radiation on health ... coloring. TUNEL staining ...
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Prognostic Value of p53, Glutathione STransferase and Thymidylate Synthase for Neoadjuvant Cisplatin PowerPoint PPT Presentation
Prognostic Value of p53, Glutathione STransferase and Thymidylate Synthase for Neoadjuvant Cisplatin - 95 % of cervical cancers contain detectable HPV DNA ... GST/HPV L1 fusion protein. Produced in tobacco plants. Simple extraction and purification process ...
95 % of cervical cancers contain detectable HPV DNA ... GST/HPV L1 fusion protein. Produced in tobacco plants. Simple extraction and purification process ...
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The Effects of Deleting Cytosolic Thioredoxin Reductase on p53 Target Gene Expression PowerPoint PPT Presentation
The Effects of Deleting Cytosolic Thioredoxin Reductase on p53 Target Gene Expression - ... Gadd45, Bax, PUMA. Gene transcription ... PUMA. Experiment. Data analysis ... Higher mRNA levels of Gadd45, Bax-a, PUMA, p21, and mdm2 were predicted in wild ...
... Gadd45, Bax, PUMA. Gene transcription ... PUMA. Experiment. Data analysis ... Higher mRNA levels of Gadd45, Bax-a, PUMA, p21, and mdm2 were predicted in wild ...
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GLI2 and P53 Cooperate to Regulate IGFBP-3 Mediated Chondrocyte Apoptosis in the Progression From Benign to Malignant Cartilage Tumours PowerPoint PPT Presentation
GLI2 and P53 Cooperate to Regulate IGFBP-3 Mediated Chondrocyte Apoptosis in the Progression From Benign to Malignant Cartilage Tumours - ... Heather Whetstone, Qingxia Wei, Elaine Mau, Benjamin Alman, Jay Wunder ... Dr. Jay Wunder. Dr. Cohick. Committee members. Dr. Eldad Zachsenhaus. Dr. Rita Kandel ...
... Heather Whetstone, Qingxia Wei, Elaine Mau, Benjamin Alman, Jay Wunder ... Dr. Jay Wunder. Dr. Cohick. Committee members. Dr. Eldad Zachsenhaus. Dr. Rita Kandel ...
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Correlation of p53 Mutations with Resistance to Platinum-based chemotherapy and Shortened survival in Ovarian Cancer PowerPoint PPT Presentation
Correlation of p53 Mutations with Resistance to Platinum-based chemotherapy and Shortened survival in Ovarian Cancer - p53 gene=tumor suppressor gene most common and frequented in human cancers. ... p53 mutation more frequent with ovarian carcinoma III and IV ...
p53 gene=tumor suppressor gene most common and frequented in human cancers. ... p53 mutation more frequent with ovarian carcinoma III and IV ...
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A Possible Mechanism of Carcinogenesis The Electric Charge Transport Properties of p53 PowerPoint PPT Presentation
A Possible Mechanism of Carcinogenesis The Electric Charge Transport Properties of p53 - E. Yavin et al. (JK Barton group), PNAS 103, 3610 (2006) ... repair processes (proposed by J.K. Barton) is to detect the lesions by probing ...
E. Yavin et al. (JK Barton group), PNAS 103, 3610 (2006) ... repair processes (proposed by J.K. Barton) is to detect the lesions by probing ...
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A mathematical model of the digital response of p53 to DNA damage in single cells PowerPoint PPT Presentation
A mathematical model of the digital response of p53 to DNA damage in single cells - ... of New Jersey, Robert Wood Johnson School of Medicine, New Brunswick, NJ ... which transcribes genes that induce cell cycle arrest, DNA repair and apoptosis. ...
... of New Jersey, Robert Wood Johnson School of Medicine, New Brunswick, NJ ... which transcribes genes that induce cell cycle arrest, DNA repair and apoptosis. ...
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Diapositive 1 PowerPoint PPT Presentation
Diapositive 1 - ... Actin B C E1 E2 E3 DES p53 ER Actin p53 C E2 C E2 C E2 C E2 Control MG UV ActD ER p53 Actin A 10 100 0 2 4 6 E2 E2+UV Hours of chase ERa levels ...
... Actin B C E1 E2 E3 DES p53 ER Actin p53 C E2 C E2 C E2 C E2 Control MG UV ActD ER p53 Actin A 10 100 0 2 4 6 E2 E2+UV Hours of chase ERa levels ...
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Chapter 12~ The Cell Cycle PowerPoint PPT Presentation
Chapter 12~ The Cell Cycle - ... cell ALL cancers have to shut down p53 activity p53 discovered at Stony Brook by Dr. Arnold Levine p53 is the Cell Cycle Enforcer DNA damage is caused by ...
... cell ALL cancers have to shut down p53 activity p53 discovered at Stony Brook by Dr. Arnold Levine p53 is the Cell Cycle Enforcer DNA damage is caused by ...
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Cancer as a genetic disease PowerPoint PPT Presentation
Cancer as a genetic disease - Breast cancer and p53. osteoclasts. neutrophils. P53 and the bax gene. Example ... Expansion. Now, Let's look more closely at 2 cancers & their multi-step progression ...
Breast cancer and p53. osteoclasts. neutrophils. P53 and the bax gene. Example ... Expansion. Now, Let's look more closely at 2 cancers & their multi-step progression ...
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Cell Growth PowerPoint PPT Presentation
Cell Growth - Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes Gene ...
Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes Gene ...
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sequencing of the human -> functional genomics PowerPoint PPT Presentation
sequencing of the human -> functional genomics - 4 sequencing of the human - functional genomics Gene-expression microarrays and RNA interferences (RNAi) ATM/NF B and ATM/p53-mediated ...
4 sequencing of the human - functional genomics Gene-expression microarrays and RNA interferences (RNAi) ATM/NF B and ATM/p53-mediated ...
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Genes and Cancer PowerPoint PPT Presentation
Genes and Cancer - ... tissues Multistep model for colon cancer APC K-ras DCC p53 p53 implicated in about half of all cancers Li- Fraumeni syndrome: a mutation ...
... tissues Multistep model for colon cancer APC K-ras DCC p53 p53 implicated in about half of all cancers Li- Fraumeni syndrome: a mutation ...
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This is our sample with two lines of text to read. PowerPoint PPT Presentation
This is our sample with two lines of text to read. - Programmed Cell Death. Mitochondria in Apoptosis. Caspase Cascade. Granzyme B ... ATM/p53 Signaling Pathway. Integrin Signaling in Cell Survival and Death ...
Programmed Cell Death. Mitochondria in Apoptosis. Caspase Cascade. Granzyme B ... ATM/p53 Signaling Pathway. Integrin Signaling in Cell Survival and Death ...
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Oscillation patterns in biological networks PowerPoint PPT Presentation
Oscillation patterns in biological networks - p53 system - regulates apoptosis in mammalian cells after strong DNA damage ... Circadian oscillations in cyanobacteria. Ken-Ichi Kucho et al. Journ. Bacteriol. ...
p53 system - regulates apoptosis in mammalian cells after strong DNA damage ... Circadian oscillations in cyanobacteria. Ken-Ichi Kucho et al. Journ. Bacteriol. ...
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10-1 Cell Growth PowerPoint PPT Presentation
10-1 Cell Growth - 10-1 Cell Growth Growth and Development!! * p53 antioncogene p53 is a tumor suppressor gene found mutated in about half of human cancers. It encodes a gene regulatory ...
10-1 Cell Growth Growth and Development!! * p53 antioncogene p53 is a tumor suppressor gene found mutated in about half of human cancers. It encodes a gene regulatory ...
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Cell Cycle and Radiosensitivity PowerPoint PPT Presentation
Cell Cycle and Radiosensitivity - ... cell cycle progress G1 phase arrest Avoid DNA replication Dependent on the function status of p53 G1 arrest and p53 pathway Irradiation---DNA damage ...
... cell cycle progress G1 phase arrest Avoid DNA replication Dependent on the function status of p53 G1 arrest and p53 pathway Irradiation---DNA damage ...
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Pay attention to how many cells there are. PowerPoint PPT Presentation
Pay attention to how many cells there are. - Skin Cancer Most skin tumors are benign and do not metastasize A crucial risk factor for nonmelanoma skin cancers is the disabling of the p53 gene Newly developed ...
Skin Cancer Most skin tumors are benign and do not metastasize A crucial risk factor for nonmelanoma skin cancers is the disabling of the p53 gene Newly developed ...
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Cancer and Genetics PowerPoint PPT Presentation
Cancer and Genetics - In this 1 3 2 Protein kinases 2 3 Active form of p53 DNA damage in genome 1 Mutations that knock out the p53 gene Can lead to excessive cell growth and cancer ...
In this 1 3 2 Protein kinases 2 3 Active form of p53 DNA damage in genome 1 Mutations that knock out the p53 gene Can lead to excessive cell growth and cancer ...
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The tyrosine phosphatase SHP2, encoded by PowerPoint PPT Presentation
The tyrosine phosphatase SHP2, encoded by - Functions of TAp63 and p53 in restraining the development of metastatic cancer. Tan EH, Morton JP, Timpson P, Tucci P, Melino G, Flores ER, Sansom OJ, Vousden KH, ...
Functions of TAp63 and p53 in restraining the development of metastatic cancer. Tan EH, Morton JP, Timpson P, Tucci P, Melino G, Flores ER, Sansom OJ, Vousden KH, ...
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Disclosure PowerPoint PPT Presentation
Disclosure - Add normal tumor suppressor gene-p53 or Rb. Add anti-sense oligonucleotide to oncogenes (bcr-abl) ... Retinoblastoma (RB) Increase Anti-tumor Immune Responses ...
Add normal tumor suppressor gene-p53 or Rb. Add anti-sense oligonucleotide to oncogenes (bcr-abl) ... Retinoblastoma (RB) Increase Anti-tumor Immune Responses ...
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Cells and Organisms PowerPoint PPT Presentation
Cells and Organisms - If you inhibit cdk function, Rb DOES NOT get hyperphosphorylated and E2F is NOT ... senescence: a non-dividing state from which cells do not recover (mutate p53/Rb) ...
If you inhibit cdk function, Rb DOES NOT get hyperphosphorylated and E2F is NOT ... senescence: a non-dividing state from which cells do not recover (mutate p53/Rb) ...
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Basic Concepts of Cancer PowerPoint PPT Presentation
Basic Concepts of Cancer - ... (p53 is #1 example) ... so need 2 hits Chemical damage to DNA Epigenetic modifications, base substitutions Aromatic hydrocarbons, aromatic amines Insecticides, ...
... (p53 is #1 example) ... so need 2 hits Chemical damage to DNA Epigenetic modifications, base substitutions Aromatic hydrocarbons, aromatic amines Insecticides, ...
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B-CLL PowerPoint PPT Presentation
B-CLL - ... Median duration of response 8 months - Alemtuzumab is active in CLL pts with p53 mutations or deletions Lozanski G et al, Blood,2004 ...
... Median duration of response 8 months - Alemtuzumab is active in CLL pts with p53 mutations or deletions Lozanski G et al, Blood,2004 ...
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DNA damage and repair and their role in carcinogenesis PowerPoint PPT Presentation
DNA damage and repair and their role in carcinogenesis - helps to stabilize p53) Homologous repair of DSBs. via recombination. Non-homologous end joining ... Nucleotide excision repair (to remove thymine-dimers after UV) ...
helps to stabilize p53) Homologous repair of DSBs. via recombination. Non-homologous end joining ... Nucleotide excision repair (to remove thymine-dimers after UV) ...
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Cancer PowerPoint PPT Presentation
Cancer - Colon cancer. Melanomas are cancerous growths of melanocytes in the skin ... Cancer. Genes. Examples of 'cancer genes' 1993- APC Suppressor Colon. P53 ...
Colon cancer. Melanomas are cancerous growths of melanocytes in the skin ... Cancer. Genes. Examples of 'cancer genes' 1993- APC Suppressor Colon. P53 ...
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Aging and Cancer: the PowerPoint PPT Presentation
Aging and Cancer: the - How to teach an old cell new tricks! Lawrence Berkeley National Laboratory ... abrogate the senescence response. Controlled by p53 and pRB -- tumor suppressors ...
How to teach an old cell new tricks! Lawrence Berkeley National Laboratory ... abrogate the senescence response. Controlled by p53 and pRB -- tumor suppressors ...
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Gaussia Luciferase-a Novel Bioluminescent Reporter for Tracking Stem Cells Survival, Proliferation and Differentiation in Vivo PowerPoint PPT Presentation
Gaussia Luciferase-a Novel Bioluminescent Reporter for Tracking Stem Cells Survival, Proliferation and Differentiation in Vivo - ... against p53 using the psiScreen system in supernatants of human ... Efficient transduction and in vivo imaging of mesenchymal stem cells with a ...
... against p53 using the psiScreen system in supernatants of human ... Efficient transduction and in vivo imaging of mesenchymal stem cells with a ...
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Cancer Genetics PowerPoint PPT Presentation
Cancer Genetics - Cancer Genetics. From Chapter 18. Human Genetics Concepts and Applications ... More that 50% of human cancers involve an abnormal p53 gene ...
Cancer Genetics. From Chapter 18. Human Genetics Concepts and Applications ... More that 50% of human cancers involve an abnormal p53 gene ...
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Papel de la Farmacogen PowerPoint PPT Presentation
Papel de la Farmacogen - Congreso Nacional de la Sociedad Espa ola de Farmacia Hospitalaria. 30 de septiembre 2005 ... C. GALLOU, C. B ROUD AND T. SOUSSI: p53 DATABASE 12/2001 ISSUE ...
Congreso Nacional de la Sociedad Espa ola de Farmacia Hospitalaria. 30 de septiembre 2005 ... C. GALLOU, C. B ROUD AND T. SOUSSI: p53 DATABASE 12/2001 ISSUE ...
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Overview of Cervical Cancer Vaccines PowerPoint PPT Presentation
Overview of Cervical Cancer Vaccines - HPV E6/E7 proteins are capable of binding and inactivating p53 & pRb. Cancer-associated HPV types better able to do so than low-risk types. ...
HPV E6/E7 proteins are capable of binding and inactivating p53 & pRb. Cancer-associated HPV types better able to do so than low-risk types. ...
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Work%20Load%20and%20Pre%20Employment PowerPoint PPT Presentation
Work%20Load%20and%20Pre%20Employment - Work Load and Pre Employment Astrand ch. 13 p 453-472 Gallagher and Moore - Occupational Ergonomics Handbook Ch 21 p 371-383 Jackson p53, 58-70
Work Load and Pre Employment Astrand ch. 13 p 453-472 Gallagher and Moore - Occupational Ergonomics Handbook Ch 21 p 371-383 Jackson p53, 58-70
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Mutations and the code Frameshift mutations PowerPoint PPT Presentation
Mutations and the code Frameshift mutations - (because p53 probe could not anneal) ... The sticky ends hybridize and anneal and a recombinant. plasmid is generated. AATT. AATT ...
(because p53 probe could not anneal) ... The sticky ends hybridize and anneal and a recombinant. plasmid is generated. AATT. AATT ...
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Cancer is a Disease of Abnormal Growth Regulation PowerPoint PPT Presentation
Cancer is a Disease of Abnormal Growth Regulation - Activating mutations in AKT or inactivating mutations in PTEN ... p53 - Activated by DNA damage. ... Active caspase-8 activates 'downstream' caspases, which ...
Activating mutations in AKT or inactivating mutations in PTEN ... p53 - Activated by DNA damage. ... Active caspase-8 activates 'downstream' caspases, which ...
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Impact of DNA Repair Mechanisms on Resistance to alkylating therapeutic agents PowerPoint PPT Presentation
Impact of DNA Repair Mechanisms on Resistance to alkylating therapeutic agents - Compared to TMZ alone, the combination of MX TMZ has. No ... Blocking BER efficiently potentiate TMZ-antitumor. Effect bypassing MMR and p53 genetic status. ...
Compared to TMZ alone, the combination of MX TMZ has. No ... Blocking BER efficiently potentiate TMZ-antitumor. Effect bypassing MMR and p53 genetic status. ...
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APOPTOSIS: An overview PowerPoint PPT Presentation
APOPTOSIS: An overview - can be initiated intrinsically through DNA damage ... Programed Cell Death helps maintain Health DNA DAMAGE p53 The bcl-2 family BH4 BH3 BH1 BH2 TM N C Receptor ...
can be initiated intrinsically through DNA damage ... Programed Cell Death helps maintain Health DNA DAMAGE p53 The bcl-2 family BH4 BH3 BH1 BH2 TM N C Receptor ...
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