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SUIVI MOLECULAIRE DE LA LEUCEMIE A PROMYELOCYTES Menif S.,Chelbi A. Laboratoire H matologie Institut Pasteur de Tunis INTRODUCTION Remaniement RARA (17q21) PML t(15 ...
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Platelets Erythrocyte Band neutrophil Neutrophil Basophil Eosinophil Degenerating neutrophil Monocyte Small lymphocyte Large lymphocyte Proerythroblast ...
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Molecular Pathogenesis of Severe Congenital Neutropenia
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Acute Leukaemia Dr N Holland RARE= rara response element. RARE= rara response element. What are the Acute Leukaemias? Leukaemia Meaning white blood Malignancy ...
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Leukemias Etiology of Leukemias General outlines Acute leukemias Single cell mutation with freezing farther cell s differentiation and maturation in early ...
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Chronic Leukemias C M L C L L CML A clonal disease results from an acquired genetic change in a pluri-potential hemopoietic stem cell within the BM.
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Acute leukemia, suspicious for chronic myelogenous leukemia. Hospital Course ... Acute Myeloid Leukemia, FAB class M2. Hospital Course ...
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... speaking male who presents to the walk-in clinic complaining of 6 months of ... later, the patient presented to the Walk-in Clinic because of worsening of his ...
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Bone Marrow Examination (BME) contents The developmental sequence of marrow cells Indications and contraindications of bone marrow examination ...
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Chronic Leukemias C M L C L L CML A clonal disease results from an acquired genetic change in a pluri-potential hemopoietic stem cell within the BM.
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Bleeding Disorders Meera Shreedhara 8/25/08 What is it? A bleeding disorder is an acquired or inherited tendency to bleed excessively Mechanisms of bleeding Vascular ...
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Acute Myeloid Leukaemia Dr. Soheir Adam, MRCPath Assistant Professor Department of Haematology, KAUH Acute Myeloid Leukaemia Definition - It is a clonal malignant ...
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... 45 mg/m2/ day (max. 90 days) Inj Daunorubicin 60mg/m2 (day 3 onwards) Consolidation 3 cycles Inj Daunorubicin 60mg/m2 Maintenance ...
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MLAB 1315- Hematology. Keri Brophy-Martinez ... Leukemia is a malignant disease of hematopoietic tissue characterized by ... Chloramphenicol, phenylbutazone ...
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ADVIA 120 TECHNOLOGY ADVIA 120 Sample Handling Unified Fluidics Circuit Unified Fluids Circuit (UFC) Dividing the Sample ADVIA 120 METHODS Calculating reported ...
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The RBC's demonstrate minimal variation in size (anisocytosis) and shape (poikilocytosis) ... (variation in size) and poikilocytosis (variation in shape) ...
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... ++ or +++ THE END THE END Hematology Analyzer Complete Blood Count (CBC) White Blood Cell Differential (Diff) Reticulocyte Analysis (Retic) ...
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Fully mature granulocytes are stimulated by chemotactic factors and leave the ... CSF specificity is mediated by receptor sites on precursors and on mature cells ...
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HAEMATOLOGY PRESENTATION TZE YENG YEOH MBChB II (2003) CASE 1 -1 Mary, 31 year old lady. Presented to her GP with non-tender lumps in her neck. Otherwise, feeling well.
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... CML CML vs Leukemoid Reaction Chronic Lymphocytic Leukemia Elderly age Anemia, fever & bleeding slow over years. Lymphocytosis & Lymphadenopathy Spleen, ...
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... not sufficient to cause MDS/AML in mice. McLemore et al, J. Clin. ... Harvest bone marrow at 3 hours. Sort Kit /Sca /Lin- (KSL) cells. RNA Expression Profiling ...
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... disease Myeloid vs Lymphoid Based on the primary cell line involved Leukemias Lymphoid CLL ALL Myeloid CML AML Chronic Lymphocytic Leukemia CLL ...
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William Osler s Impact on the Principles and Practice of Medicine Barry Cooper, MD Baylor Sammons Cancer Center Dallas, Texas * Blood Plates in 1892 ...
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Acute leukaemia Dr. MO Kehinde Department of Medicine CMUL/ LUTH Thank you For Your Attention ACUTE MYELOID LEUKAEMIA Def.Introduction . Clonal malignant disease of ...
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There are four major types of Leukemia, Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Chronic Myeloid Leukemia, and Chronic Lymphocytic Leukemia.
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The hematopoietic compartment consists of irregular ... Hematopoietic compartment. Bone marrow smear. Blood cells are produced in the hematopoietic compartment and ...
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Pathology 13.27 Hyperplastic due to acute leukemia. Slides. Bone Marrow Aspiration ... Saunders # 349 Lack of maturation, monotonous population, acute leukemia ...
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Chronic leukemias Chronic leukemias Chronic myelogenous (granulocytic) leukemia Is characterized by an unregulated proliferation of myeloid elements in the bone ...
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usually fatal within weeks to months without chemotherapy ... curative vs palliative intent. Principles of treatment. combination chemotherapy ...
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toxic changes in cells - d hle bodies, toxic granules or vacuolation ... b) Toxic vacuolation: neutrophils have vacuoles in cytoplasm. c) D hle bodies: ...
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The condition of having too few red blood cells. ... anemia -Spoon nails-Iron deficiency -Dystrophic nails-Dyskeratosis congenita ...
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Patient 1 CC: 5YOWFpresents with fever, marked weakness, pallor, bone pain, and bleeding from her nose HPI: progressively increasing fatigability and infections over ...
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... Large and atypical nucleolus Immature granular chromatin Eosinophilia Infection Parasitic Fungal Viral FeLV Streptococcus, Staphylococcus spp. Allergy/asthma Immune ...
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Function is regulated by. phosphorylation. interaction with other proteins eg Bad ... induction occurs independently of the retinoid pathway and may be mediated, ...
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The white cell The five types of leucocytes found in peripheral blood are: polymorphonuclear leucocytes (neutrophil leucocytes) eosinophil leucocytes
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... etc.) Hematopoiesis Erythropoiesis Granulopoiesis Megakaryopoiesis Lymphopoiesis B-cell maturation B-cell transformation Lymph node Spleen T-cell ...
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Peripheral Blood, Bone Marrow, and Tissue Morphology: Neoplastic Hematology Charles Timmons, MD, PhD UT Southwestern Medical Center at Dallas Dallas, Texas
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... acute lymphoblastic leukemia/lymphoma (ALL) acute myelogenous leukemia (AML) various subtypes of ALL and AML exist, depending on the specific lineage or ...
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HSC home to marrow & are quiescent for. up to 48 hrs. Krause et al, 2001 Cell 105:369 ... Bone marrow stromal cells may differentiate into: cardiac muscle cells and ...
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Lymphoma classification, but principles extended to other haemic ... Vacuolation. PAS ve. Dyserythropoiesis. Dyserythropoiesis. Dysgranulopoiesis. Small size ...
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Nature 1973 Jun 1;243(5405):290-3 Related Articles, Books, OMIM, LinkOut ... Science. 1990 Sep 28;249(4976):1577-80. Medline 91019420 ...
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Px-The coagulation system is activated leading to microthrombi and global ... Causes progressive dysphagia. Barium swallow shows dilated esophagus with distal stenosis ...
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... defects in hemoglobin, typically due to genetic mutations in globin genes. ... common mutation is that of beta-globin, leading to the HbS of sickle cell ...
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Liver disease, thalassemia postsplenectomy,HgbC dz, Fe deficiency ... PMN function- severe, recurrent pyogenic infections (decrease killing and chemotaxis) ...
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... Aberrant Lymphoid Antigen Expression in Acute Myeloid Leukemia in Saudi Arabia. ... Myeloid antigens in childhood lymphoblastic leukemia:clinical data point to ...
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3 wk : formation of blood islands from yolk sac. 6 wk : liver becomes ... (crenated cells, burr cells) regularly contracted cells with smooth surface undulation ...
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ACUTE LEUKAEMIAS Major advances in the understanding and treatment in recent years has enabled the possibility of a cure for some acute leukaemias, e.g. Common ...
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Classified according to: 1) Cell line lymphoblastic or myeloblastic ... marrow, chemotherapy, vit B12 deficiency, leukemia, auto-inmmune destruction of ...
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Hairy cell leukemia. This is mainly a disease of elderly men ... atypical mononuclear lymphocytoid cells with hairy projections on their surfaces ...
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Chronic leukemias Chronic leukemias Chronic myelogenous (granulocytic) leukemia Is characterized by an unregulated proliferation of myeloid elements in the bone ...
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Chronic Myeloid Leukemia (CML) and Targeted Therapy CML Proliferative disorder of hematopoietic stem cells Well-characterized clinical course Philadelphia (Ph) chromosome
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Acute Leukemia: The Ultimate Hematological Emergency. Khaled el-Shami MBBCh PhD. AML: Incidence ... Surrender. AlloBMT. Clinical. trial. Risk stratify. Good ...
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Approach to Patients with Anemia
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CQAS Meeting 6 November Morphology Session
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Leukemia DR. SHAHID MAHMOOD
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