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Specificity: Peptide bond on carboxyl side of aromatic side chains (Y, W, F) ... Activated H2O attacks the C=O group of the scissile peptide bond ...
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Scissile phosphate is labelled with an asterisk. ... Conformational changes after scissile bond breakage discharge the catalytic ...
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Processing, combined predictions, and rational epitope selection ... of cleavage-determining amino acid motifs present around the scissile bond ...
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Feedback Control Between S-phase and Mitosis. Feedback control ensures ... Scissile Subunit (Scc1) Cleaved at M/A. From Uhlman (2001) Cur. Op. Cell Biol. 13:754 ...
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Composition and linear arrangement of the GFP2 and DsRed2 reporters are illustrated. ... arrow indicating the scissile bond of 3Cpro and the underlined residues ...
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Vocabulary Lessons The Past. Assign. Define. Test. Transfer? Bourgeois. Mephitic. Nacreous. Nugatory. Scissile. Kid. Communication. Hand gestures. Body language ...
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Statistical frequency = 1 in 46 or 1/4096 ... New clamp at the scissile phosphate. Isosteric substitution retains symmetry. Adaptive Binding ...
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'The serine protease of RNA enzymes' The known smallest (and ... A Mg2 was artificially added in the middle of O2Ps of A9 and scissile site. Recent simulations ...
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Mechanism of lysozyme Lysozyme digests bacterial cell walls by breaking b(1- 4) glycosidic bonds between (N- acetylmuramic acid (NAM) and N-acetylglucosamine (NAG)
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Strand unwinding at the replication fork during DNA replication, causes the ... The torsional stress at the pre-fork region must be relieved or the strand ...
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Catalytic Mechanism of Chymotrypsin 1 Chymotrypsin Protease: catalyze hydrolysis of proteins in small intestine Specificity: Peptide bond on carboxyl side of ...
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... B enables the conserved regions to approach each other, buries the active core. ... 5 -OH leaving group buried deeply between two domains ...
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You should have your paper topic approved by Prof. Lippard this week, if you ... residues in the active site that position the substrate moiety for bond scission. ...
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The grade for this course will be determined by a term exam (35%), a written ... residues in the active site that position the substrate moiety for bond scission. ...
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to rate equation. The half-life of a first order reaction can be used to determine the amount of ... an energetic b particle and has a half-life of 14 days. ...
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... surface by shielding the positively charged sites on the gp-120 glycoprotein ... Cosalane binds to the HIV gp-120 protein. Viral Coreceptor Antagonists ...
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Nextgeneration DFTbased quantum models for simulations of biocatalysis
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Chapt. 8 Enzymes as catalysts Ch. 8 Enzymes as catalysts Student Learning Outcomes: Explain general features of enzymes as catalysts: Substrate - Product
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Numbers of protein coding genes do not scale strongly with ... Hairpin flanking sequences. Not yet found in plants. Maybe Dicer does its job? 1,374 aa ...
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There are two general ways to control enzymatic activity. 1. Control the amount or availability of the enzyme. ... Bovine Trypsin. Bovine trypsin. The kinetics show ...
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Glycerol sent to liver Converted to DHAP; entry into glycolysis. ... in complex with serum albumin, fatty acid concentrations in blood approach 2 mM. ...
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Directed Mutagenesis and Protein Engineering * HTS of enzymes with Phage Display Kilde: Reymond, Chapter 6 (HTS screening and selection of Enzyme-encoded genes) HTS ...
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... the active site, displacing the aG and positioning the 3'exon for exon ligation. ... Exon ligation and intron release are accomplished by the O3' of the 5'exon ...
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TIM 22 Insertion de certaines prot ines dans la membrane interne dont transporteur de ATP ... Power-stroke model. Stage 3 ... Arrowheads point to tubular regions of ...
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... that replace U7 with a pyridine-4-one .Because the functional groups ... However, the pyridine-4-one modification would destabilize the U7-A14 pair seen ...
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Mechanism Topics Mechanisms Induced-fit Tight Binding of Ionic Intermediates Serine proteases Other proteases Lysozyme Regulation Thermodynamics Enzyme availability ...
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Saint-Saens, Berlioz. and some French carols. Figure 14-15 Effect of pH on the initial rate of the reaction catalyzed by the enzyme fumarase. ...
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