Xenobiotics PowerPoint PPT Presentations

Chemical Carcinogens - aflatoxin. Environmental Pollutants - polychlorinated biphenyls (PCBs) ... Metabolism of Aflatoxin. Rapid Detoxication of Aflatoxiin Epoxide by ...

Hormonally Active Agents (HAA's) Human and animal ... (PCP's) Disinfectants, Deodorants, Fragrances, Flavoring agents, insect repellants, sunscreens. ...

Detoxification and excretion of compounds that are strangers to human beings

METABOLISM OF XENOBIOTICS dr Agus Budiman Xenobiotics ( Xenos = strange) are compounds that are foreign to the body. It includes drugs, food additives, pollutants etc ...

Metabolism of xenobiotics Vladim ra Kvasnicov XENOBIOTICS = compounds foreign to the body ENTRANCE TO THE BODY digestive tract blood LIVER lungs blood ...

Biodegradation of Xenobiotic Compounds Xenobiotics : compound have been produced artificially by chemical synthesis for industrial or agricultural purposes e.g ...

Leads to large molecular weight products. Is always associated with oxygen ... (a ) A family of metallo-enzymes (b ) Is an inducible enzyme(s) ...

Chapter 3 Transportation and Transformation of Xenobiotics Toxicology-chapter 3 * Toxicology-chapter 3 * Phase I biotransformation Hydrolysis: functional group such ...

Wastewater, Pesticides, herbicides, petrochemicals and products (eg. ... used by oil industry to destroy oily wastes, also used for sludges from sewage ...

Biological Methods 10.1-Basic Microbial Metabolism 10.2 Biodegradation of Xenobiotics Materials are taken from the Textbook: Hazardous Waste Management. 2nd Ed.

Metabolism of Bile Pigments and Jaundice ... (xenobiotics ...

Toxicology 3. toxicokinetics Biotransformation: Hepatic-first pass metabolism Xenobiotics absorbed from the gastrointestinal tract Exceptions: Mouth (Nitroglycerine,

MLAB 2401: CLINICAL CHEMISTRY KERI BROPHY-MARTINEZ Toxicology: Overview TOXICOLOGY Study of adverse effects of xenobiotics in humans Xenobiotics- chemicals/drugs not ...

What is the poison The fate of poison in organism Application mode and bioavailability,metabolism Inhalation-Sniffing ... BIOTRANSFORMATION OF XENOBIOTICS ...

... Biogas process Other Energy Carriers Effluent qualiuty Xenobiotics/Patogener Molecular probing Microbial activities Anaerobes Metabolism Pathways ...

Biotransformation of Toxicants Lect 6 Metabolism (Biotransformation) Many xenobiotics undergo chemical transformation (biotransformation; metabolism ...

The global Bioanalytical Testing Services size is projected to reach a CAGR of 12.59% from 2022-2028. Bioanalysis involves quantitative measurement of xenobiotics, like small molecule drugs and their metabolites and biological molecules. Bioanalytical testing services are used in the development and validation of robust bioanalytical methods in body fluids and tissue specimens. These tests are used to support pre-clinical and Phase I through Phase IV clinical trials.

Biosynthesis of Macromolecules Anabolism - use energy (ATP) from catabolism - use carbon from sugars, lipids, proteins, or any other carbon source (xenobiotics) to ...

Biodegradation. Of. Xenobiotics. Synthetic chemicals NOT ... DDT : Microbial Biodegradation Model. IUPAC Name: 1,1,1-trichloro-2,2-bis-p-chlorophenylethane ...

Com' coinvolta nella risposta agli xenobiotici? ... Helen E. Bryant, Niklas Schultz, Huw D. Thomas, Kayan M. Parker, Dan Flower, ...

Glucosylation of xenobiotics in planta. Ripe strawberry fruits were injected with 10 mM 3-hydroxyflavone (A), 3-hydroxycoumarin (B) and 2-naphthol (C).

The study of the adverse effect of xenobiotics on living systems ... Aconite (wolfsbane) Chinese herb (neurotoxin) Hippocrates and Nicander. Hippocrates (400 B.C. ...

Metabolism. Chemical transformaion of xenobiotics. Occurs in ... Oxidize diamines, histamine. MAO like enzymes in plants. Non-microsomal enzymes (Phase 1) ...

Metabolism. Chemical transformaion of xenobiotics. Occurs in ... Oxidize diamines, histamine. MAO like enzymes in plants. Non-microsomal enzymes (Phase 1) ...

The study of the interaction between exogenous chemicals (or xenobiotics) and ... Biochemistry. Chemistry and. Physiology. The main aims of the subject are to: ...

Know how these processes may affect the action of xenobiotics ... clinical or physiological condition. first-pass (pre-systemic) metabolism. Excretion of drugs ...

COST Action 636 Xenobiotics in the Urban Water Cycle, ... Presented by: Peter Steen Mikkelsen. Project Coordinator. Institute of Environment & Resources, ...

... in representative plankton living in sea surface layer and in representative benthic organism(s) ... Biokinetics in plankton & benthic organisms. xenobiotics ...

Pesticides are degraded by many different mechanisms. Physical, chemical, and biological agents play significant roles in the transformation of insecticide, herbicide, and fungicide molecules to various degradation products. The physical and chemical properties of the degradation products are also different from those of the parent compound, and their fate and significance in the environment also are altered with the structural changes.

A variety of Systems in Toxicology. Drug and polluants toxicity: differences and similarities ... Predictive and Mechanistic Toxicology. Can New Technologies help? ...

... Improve Pharmacokinetic Properties Improve pharmacokinetic properties. pharmacokinetic = The study of absorption, distribution, metabolism and excretion of a ...

Procainamide Unchanged in Urine, 59% 24% Fast 17% Slow 3% Unchanged in Urine, 85% 1% NAPA 0.3% Procainamide Additional Effects on Drug Metabolism Species Differences ...

3- biochemical analysis (GC-MS, LC-MS, NMR) 4- data pre-processing (base ... Examples related to gut microbiology. Concluding remarks. Metabolomics. Metabolism ...

All organisms are exposed constantly and unavoidably to foreign chemicals or ... Example: Benzo[a]pyrene undergoes a series of metabolic reactions producing a ...

Harriet Hardy. Others ? After World War II. Arnold Lehman ... Ed Palmes. Ben Van Duuren. Mort Lippman. Merril Eisenbud. Arthur Upton. Max Costa ...

Located in endoplasmatic reticulum (liver and other cells) ... from pieces of the endoplasmic reticulum present in homogenates of tissues or cells: ...

defines where in the body a xenobiotic will go after absorption ... Assumes xenobiotic enters the first compartment. Assumes that xenobiotic is distributed to ...

Title: Cytochrome P450 and Polymorphism Subject: Cytochrome P450, ADME, Polymorphisms Author: Michael Hutter Last modified by: Michael Hutter Created Date

Title: Standardisation and Validation of Analytical Methods Author: fs Last modified by: Anna Ledin Created Date: 2/25/2004 1:34:26 PM Document presentation format

Used machine learning algorithms: decision trees, neural networks, support ... That mean: The same genotype enables different phenotypes ...

The Effect of Hydra Head Activator on the Regeneration Rates of Heads and Tails of Planaria (Dugesia Tigrina) By Paris Thatos Abstract There are approximately 1.6 ...

Process Biochemistry, 36(5): 451-458. D nmez, G., 2002. ... Process Biochemistry, 38(5): 751-762. Aksu, Z. and D nmez, G. 2003. ...

BIOREMEDIATION Ji Mike Bioreactors Bioaugmentation vs. biostimulation: Biostimulation involves the modification of the environment to stimulate existing ...

Classify microorganisms according to their characteristics and metabolic processes. ... Xenobiotic chemicals - Chemicals not naturally found in the environment. ...

Concentration of chemical in plasma and other tissues decreases similarly by ... B) a semilog plot of concentration versus time yields a straight line ...

METABOLIC CHANGES OF DRUGS AND RELATED ORGANIC COMPOUNDS Chapter 2 Roselyn Aperocho-Naranjo USPF-College of Pharmacy rose_may26@yahoo.com www.roselynnaranjo.vze.com

CYP 1A2 omeprazole, insulin, aromatic hydrocarbons (cigarette smoking, charbroiled meat) ... or conversely efflux from compartments, whereby ATP is consumed. ...

... of SOM conformation (DSC and 1H-NMR) and of the following xenobiotic fractions: ... alanine, catechol) to determine priming effects on xenobiotic mineralization. ...

Occurrence in most of the compartments of the urban water ... September 2006 (Luxembourg): Results of interlaboratory exercise. Results of literature survey ...

Where do biotransformations occur? Liver is the principal organ of drug metabolism although every tissue has some ability to metabolize drugs.

Drug Metabolism and Pharmacogenetics Brendan Stamper University of Washington Dept. of Medicinal Chemistry * * * * * Figure 2. Two types of variability in drug action.

Nutrition

Metabolism of Chemicals

The use of bacteria and fungi and plants to break down or degrade ... 90% of the chemical substances classified as hazardous today can be ... auto body shops ...

Laboratoire de Cin tique des X nobiotiques Facult de Pharmacie Toulouse ... In recent years, there has been a constant search for in vitro methods that are ...