Biology of ZAP-70 and why it is a High Risk prognostic factor in CLL ... Carlos E. Prada, M.D. Jan Bole, R.N. Undergrad Students. Olivier Loria. Jorieth Jose ...
GADS = Brb2-like adaptor downstream of Shc. GEF= guanine ... SLP76= SH22-containing leukocyte-specific protein of 76 kD. ZAP70= zeta associate protein of 70 kD ...
TRASDUZIONE DEL SEGNALE DA PARTE DI RECETTORI IMMUNI attivazione C-type lectins ZAP70 Fyn/ Lck ... ITAM E SYK SH3 SH2 KINASE ... proteine favorenti la ...
Title: Diapositiva 1 Author: Francesco Last modified by: O.A.C.S. Document presentation format: Presentazione su schermo Other titles: Times New Roman Lucida Sans ...
Antigen recognition out + - Lipid bilayer of plasma membrane in Signal transduction (contains one or more ITAMs) Src-family tyrosine kinase reversibly associated with ...
Activating receptors could be antibodies, stress inducible MHC class I-like ... If both an inhibitory and activating signal is detected the NK cell will not be ...
Function in innate immunity to protect against viruses, bacteria, ... Orangutan. P. Parham. Mice don't have KIR genes. Mice have Ly49 genes that do the same job ...
The role of the T cell specific adapter protein (TSAd) in T cell ... Knut Martin Torgersen. Tor Lea. Anne Spurkland. Tomas Mustelin. MS genetics. Hanne F. Harbo ...
Przewlek a bia aczka limfocytowa Dr n.med. Marta Bara ska Przewlek e bia aczki limfocytowe Grupa chor b limfoproliferacyjnych wywodz cych si z dojrza ych ...
... man with a history of chronic lymphocytic leukemia (CLL). Diagnosed in 1993. ... Symptoms and signs: Key is the thermal amplitude. Acrocyanosis. Hemoglobinuria ...
Paediatrics teaching ppt Immunodeficiency diseases Xinhua Hospital Shanghai Institute for Pediatric Research Tong-Xin Chen Immunodeficiency diseases ID A group of ...
Location: Upstream, promoter, intronic, exonic, downstream, etc. ... Imbalance: A deviation in the expected relative abundancy of allelic transcripts ...
Update on Cellular Immunodeficiencies Francisco A. Bonilla Children s Hospital Boston Harvard Medical School MA SCID NBS Laboratory Testing Algorithm Overview (All ...
These tyrosines are phosphorylated by various src family kinases upon ... phospho-tyrosines in certain sequence contexts, including phosphorylated ITAMs. ...
Bayesian network models of Biological signaling pathways karensachs@stanford.edu * Important for discovering novel cross talk between pathways or to study effects of ...
Score 4 or 5: typical CLL (Matutes score) Most cells in Go/G1 accumulation by ... mutational status do not affect response rates to F R (Byrd, et al. ASH 2004. ...
Full enzymology support through Lead Optimization. Other. CK1a ... All enzymology for Hit-to-Lead in place. Protease Panel. ADAM 10. Furin. ACE 2. Caspase 8 ...
La plus fr quente des leuc mies de l'adulte. Incidence : 3-10 nouveaux ... Complications infectieuses : surtout au cours de l' volution (faible expression ...
If DCs are not infected by virus, DCs can still internalize viral antigens from the suroundings ... Influenza virus. H5N1, H1N1, etc. Evasion by hiding ...
Treatment of CLL is usually deferred until indications for therapeutic intervention ... Phase III study (LUCID) registration study launched upon these results ...
Augmente la cytotoxicit naturelle. Induit la migration tissulaire, la production d 'IL-15 ... Augmente survie, synth se d'IFN-g et cytotoxicit des cellules NK (IL ...
Department of Medical Genetics and Molecular Medicine ... vLINCL, Batten. NCL-diseases. Diagnostic DNA tests in the University of Helsinki laboratory ...
Notch gene absence can cause the abnormal wing development of fruit fly Hedgehog signal pathway: Hedgehog is secreted protein combined with cholesterol that is ...
Regulate Migration of Leukocytes Into Sites of Inflammation and of Pathogens Out ... non-adaptive immunity, i.e. production of anti-fungal and anti-bacterial peptides ...
Corso di Immunologia molecolare The MoAb in the pipeline Valentina Spaziani SOMMARIO I Parte :Dalla ricerca ai trial clinici. II Parte :MoAb in fase iniziale di ...
RANK L membranaire qui peut tre directement actif sur RANK (3) ou tre cliv par TACE ... La lyse des LB touche pr f rentiellement les LB actif pr sentant des antig nes ...
Function in innate immunity to protect against viruses, ... Adenovirus E3-k19 Retain in ER. HSV-1,2 ICP47 Blocks TAP. EBV EBNA1 Block peptide generation ...