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Industrial Biotechnology at TUHH
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What is Industrial Biotechnology ?
Industrial (white) biotechnology is the use
of micro-organisms and/or enzymes for the
sustainable production of chemicals, materials
and fuels from renewable resources
Industrial (white) biotechnology is mainly based
on fermentation technology and biocatalysis
I. Biotechnology and sustainability
I. Biotechnology and sustainability
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TUHH focuses on Industrial Biotechnology


White
Biotechnology (Industrial Biotechnology)

• Chemistry
• Fine chemicals
• - Building blocks
• - Amino acids
• Vitamins
• Antibiotics
• Bioethanol
• Biogas

TUHH focus
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Production of pharmaceutical substances using
Micro-Organisms
Example Bio-Process-Eng.
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TUHH Focal Areas Bio-Technology
Intelligent Screening Systems
- Development, optimization and application of
novel screening technologies (e.g. activity
profiling, PCR-based techniques, micro arrays)
- Identification of innovative compounds and
lead-structures for the pharmaceutical industry
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TUHH Focal Areas
Efficient biocatalysts
- Optimization and application of novel
expression systems in mesophilic host strains
(E. coli, Bacillus, Staphylococcus, yeasts)

• Improvement of recombinant biocatalysts,
  directed
• evolution

- Gene mining - using the great potential of
genome data
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TUHH Focal Areas
Downstream-processing
- Efficient product separation (production of
great quantities)
- Simplification of multi-step downstream
processes getting more product and using less
ressources
- Application of innovative membrane techniques
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Bio-Technology Related Institutes at TUHH

• Thermal Separation Processes.... G. Brunner
• Technical Biocatalysis .................... A.
  Liese
• Biosystems Engineering .............. A-P. Zeng
• Technical Microbiology ........ G. Antranikian
• Chemical Reaction Engineering.......... F. Keil
• Process System Engineering............. G. Fieg

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Example The Institute of Technical Microbiology
History Facts
Founded in 1990 4 Postdocs, 9 PhD students
and 4 technicians More than 150
publications Numerous collaborations with
scientists from academia and industry
Associated with the BiocatCollection and the
BiocatArchive Organizer of the Biocat
Conferences
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Institute of Technical Microbiology
Research Areas
Microbiology Isolation, characterization and
taxonomy of extremophilic archaea and bacteria
(psychrophiles, psychrotolerants, thermophiles,
hyperthermophiles) Fermentation under aerobic
and anaerobic conditions
Enzymology Purification and characterization of
native and recombinant enzymes from
extremophilic microorganisms Application of
enzymes in environment-friendly processes
Molecular biology Cloning and expression of
biotechnologically relevant genes from
extremophilic microorganisms Efficient
expression systems (Gram-, Gram, yeasts)
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Institute of Technical Microbiology
Equipment
Microbiology and Biotechnology
Fermentation capacity up to the 300-L scale
(aerobic/anaerobic) Downstream-processing
(centrifugation, cross-flow) Anaerobic
chamber PCR HPLC, FPLC, GC Soon Robotics
(screening, liquid handling, colony picking)
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Key technologies
Aim is to link the projects within the network
and offer service and biocatalysis experts in
the following fields
- Robotics for HTS - Enzyme collection
(BiocatCollection) - Metagenome bank
(MetaCatCollection) - Process Engineering -
Downstream processing
Provide biocatalysts to the network
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Novel biocatalysts and processes
Biocatalysis under unconventional reaction
conditions
New biotopes as source for unique enzymes
Optimization of biocatalysts
Exploit enzyme promiscuity
Run reactions at - extreme temperatures -
extremes of pH, organic solvents, detergents -
high viscosity and pressure
Process engineering, downstream processes
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Hamburg University of Technology (TUHH)
Island
Schweden
Finnland
Norwegen
Estland
Lettland
Rußland
Dänemark
Litauen
Irland
Hamburg
Niederlande
Vereinigtes
Weißrußland
Königreich
Germany
Polen
Belgien
Ukraine
Luxemburg
Tschechien
Slowak.

Republik
Moldau
Österreich
Frankreich
Schweiz
Ungarn
Rumänien
Slowenien
Kroatien
Bosnien-
Herzegowina

• Aveiro
• Portugal

Italien
Bulgarien
Montenegro
Spanien
Make-
Portugal
donien
Albanien
Griechenland
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Hamburg - Whats it like?

• 1.7 Mio inhabitants, the second city in Germany
  after Berlin
• Located in a green area, 100 km to the coast
  along the Elbe river
• Second biggest harbour in Europe, close to
  Northern and Baltic Seas
• A lot of industries and business buildings
  (Airbus, Docklands...)
• A cosmopolitan, international city with a great
  life style
• Lively cultural scene, splendid shopping and
  sports opportunities
• An exciting part of Europe with long history and
  international flair

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TUHH Campus Views
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TUHH Targets and Guidelines
founded

• 1978
• Strengthen the scientific competence in the
  Hamburg metropolitan area
• Create and maintain jobs in technology and
  technology-related areas in growing industries
• Priority of research
• Interdisciplinarity
• Innovation
• Internationality

Mission
Principles
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Some facts and figures
1978 Foundation of TUHH
1992 TUHH Technology GmbH 1999
Northern Institute of Technology 2003
Hamburg School of Logistics
4500 Students 1000
International Students from 120 countries
100 Professors
600 Scientific Staff and Lecturers 55 Mio.
Euro Budget 21 Mio. Euro Additional
Research Funds (third party, in 2006)
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10 International Masters Programmes at TUHH
Electromagnetics, Optics Microwave Engineering
Information and Communication Systems
International Production Management
Information and Media Technologies
Microelectronics and Microsystems
Environmental Engineering
Process Engineering
Materials Science
Biotechnology
Mechatronics
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European Master in Materials Science (EMMS UA,
TUHH, AAU)Joint European Master in Environmental
Studies (JEMES TUHH, UAB, AAU, UA)Global
Innovation Management (GIM UoS, AAU, TUHH)
3 ERASMUS MUNDUS Master Programmes at TUHH
EMMS JEMES GIM Attractive GRANTS for 2008/09
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Industrial Network of TUHH
Shell
Phoenix
Esso
Ixion
Flensburger Schiffbaugesellschaft
Axel Springer
SAP
Compaq
DaimlerChrysler
Siemens
Beiersdorf
Philips
Jungheinrich
Germanischer Lloyd
Airbus Industries
Körber
ThyssenKrupp Industries
Dräger
Still
bbcom
Hako
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TUHHs Mission in International Education

• Internationalization of education at TUHH
• Recruitment of highly qualified and motivated
  students
• Excellent education and integration of the
  students
• Advanced students and graduates work for or start
  to co-operate with TUHH cooperation firms
• a network of international engineers and
  executives

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Typical Curriculum of a Master Programme at TUHH
First Year Theoretical Background
Second Year Applications and research
Internship 2-3 months Project Work 3
months Masters Thesis 6 months
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Engineering main field of education at
TUHH... but not the only
Business and Management
Complementary Courses
TUHH School of Management Sciences Technology
Womens Competence Centre at TUHH
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MBA in Logistics in one year
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NIT Built to offer an exciting double degree
program
Public Private Partnerships for the sake of our
students
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Strategic Areas of Research at TUHH

• Ocean Engineering, Ship Building, Naval
  Construction
• Aircraft Systems Engineering
• Advanced Information and Communication
  Technologies
• Advanced Materials and Microsystems
• Industrial Biotechnology and Biomedical
  Engineering
• Advanced sustainable Energy Systems and Energy
  Management
• Production and Process Integrated Environmental
  Protection
• Organisation of Enterprises
• Systems of Transport and Logistic

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Surf TUHH!
www.tuhh.de www.nithh.de www.hslog.de
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See you at TUHH!