Tissue engineering Opportunities and challenges in clinical practice

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Tissue engineering- Opportunities and
challenges in clinical practice

• Prof. Riitta Suuronen, MD, DDS, PhD
• REGEA - Institute for Regenerative Medicine
• University of Tampere

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Tissue engineering

• Restoring cellular
• and / or
• organ functions
• that have been lost as a result of
• injuries
• or
• other diseases

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Legislation

• 2000 / 70 / EC
• Medical devices incorporating human plasma
  derivatives
• 2001 / 83 / EC
• Some cell therapy products
• 2002 / 98 / EC
• Blood directive
• 2004 / 23 / EC
• Tissue and cell banking directive

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Current treatment / 1
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Current treatment / 1

• prosthetic implants

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Current treatment / 2

• tissue grafts
• autologous

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Current treatment / 3

• tissue grafts
• tissue banks

• 2004 / 23 / EC
• Tissue and cell banking directive in the spirit
  of GMP (effective April 1st 2006)
• Sets standards of quality and safety for the
  donation, procurement, testing, processing,
  preservation, storage and distribution of human
  tissues and cells

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The Clinical Tissue Bank

• Bone
• Cornea
• Amniotic membrane
• Cardiac valves, Aortic blocks, Pericardium
• Cartilage
• Fascia lata
• Skin

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Legislation

• Tissue engineering directive
• under preparation
• FDA
• regulation of human tissues, cells, and
  cellular-and tissue-based products
• based on the level of risk
• minimally manipulated GTP
• more than minimally manipulated - GMP

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Tissue engineering- custom made spare parts from
the store?
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Tissue engineered finger joints
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In the future

• Specialized units
• collaborating networks
• utilizing each others core knowledge and
  competence

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Future challenges

• there is a need for reconstruction of form and
  function

• close collaboration between clinicians and
  researchers is essential for optimal outcome

• experts from all fields of tissue engineering are
  needed in the development of the perfect cure

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Future challenges

• safety
• availability
• logistics
• surgical expertise

• Centralized systems
• quality control

• Proper legislation
• not hindering the development of new products
• not delaying the clinical use of new products

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Future challenges

• Funding
• national and EU focus on tissue engineering
• major US and Japanese funding

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Unmet clinical need
S.Freud oral cancer
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Finland

• Several research groups working on tissue
  engineering in several cities
• A close collaboration between engineers, doctors
  and scientists
• European wide networking is required to achieve
  best results

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