Small Animal Radiation Therapy MicroRT

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Small Animal Radiation Therapy (MicroRT)

• Team Paragative
• Neil Mehta
• Sumona Nag
• Claudiu Diaconu

Mentors Parag Parikh, M.D. Strahinja
Stojadinovic, PhD
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Overview

• Background
• Need
• Existing Solutions
• Components of MicroRT Device
• Design Specifications
• Preliminary Analysis
• Design Schedule
• Team Organization

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Background

• Radiation therapy began in 1895 when Roentgen
  discovered the x-ray
• Early advances involved developing new radiation
  sources, learning about radiation delivery doses,
  and creating high voltage electron accelerators
• Major advances from 1980s to present
  incorporating 3D imaging (CT, MR) with radiation
  therapy to develop conformal treatment planning
  in humans

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Background
www.picture-newsletter.com/ ct/
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Background

• Recent advances in small animal imaging (microCT,
  microMR) have not been followed up by the
  inception of 3D conformal radiation therapy
• Current radiation therapy in small animals is
  analogous to human therapy from the 1950s

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Need

• Current small animal irradiation is out of date
  with todays conformal, three-dimensional
  radiation therapy
• A conformal small animal irradiator (microRT)
  could be used in preclinical micro-imaging and
  radiobiology to evaluate the response of tumors
  to therapeutic doses of radiation and the
  efficacy of radiation treatment plans

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Existing Solutions

• Gamma Knife System

http//www.answers.com/gamma20knife
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Existing Solutions

• Patent 5,745,279
• Collimator that uses sliding blocks to deflect
  the radiation-therapy beam that is guided between
  the blocks of each pair

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Existing Solutions

• Patent 5,442,675
• Dynamic collimator that changes the width of a
  fan beam of radiation so as to minimize the
  irradiation of healthy tissue at the front and
  back of the tumor

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Components of MicroRT Device

• Primary Collimator
• Secondary Collimator (Inserts)

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Components of MicroRT Device

• Source 192Ir (gamma radiation)
• Gantry
• Imaging/Positioning System
• Room Shielding
• HDR (High Dose Rate) Machine

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Components of MicroRT Device

• Stage
• Animal Holder

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Design Specifications
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Additional Design Requirements

• Interface with HDR (high dose rate)
• Interface with stage prevent collisions
• Interface with imaging/positioning system
• Need indicator light during radiation delivery
• Room shielding

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Preliminary Analysis

• Dose Rate Delivery Capability 1Gy/min

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Preliminary Analysis
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Preliminary Analysis

• Blocked radiation of 5 HVL (half value layers) by
  collimator

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Preliminary Analysis

• HVL of lead is know to be 2.5mm

?w.479, HVL of tungsten (W) 1.45mm
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Preliminary Analysis
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Design Schedule
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Team Organization

• Claudiu- Labview, DesignSafe, Progress Report
  Presentation
• Sumona Mechanical Drawings, Webpage, Final
  Report Presentation
• Neil Weekly Reports, Drafting Papers, Team
  Leader, Preliminary Report Presentation

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Questions??