Choline Supplementation

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Choline Supplementation

• Choline supplementation during pre- and early
  postnatal development produces long-lasting
  neuronal changes and cognitive enhancement

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Choline supplementation after prenatal alcohol
mitigates learning deficits
CHOLINE
SALINE
8


NO INJECTION

6

MEAN ( SEM) NUMBER OF CORRECT TRIALS
4
2
0
ETOH
PAIR FED
LAB CHOW
GROUP
3
ACTIVITY LEVEL
500
CHOLINE
SALINE
400
300
MEAN (/- SEM) TOTAL DISTANCE TRAVELED (in)
200
100
0
ETOH
GC
SC
GROUP
4
Developing Minds It's not just your child's body
that's developing though. A majority of a child's
brain development happens in their early years.
That's why Mighty Bites was designed to provide
nutrients essential to your child's developing
mind. We've added 35mg of Choline, a nutrient
necessary for proper brain development that has
been shown to help with memory.
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What do we know about factors that affect brain
development in a typical population?

• Brain continues to be plastic throughout the
  lifespan
• Enriched environments, stimulation and exercise
  enhance neuronal plasticity
• Stress impairs plasticity

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Stress exacerbates the effects of prenatal
alcohol exposure
Zimmerberg Westin, 2002
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Enriched environments
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Enriched Environments can mitigate ethanols
effects on behavior

Adapted from Hannigan et al 1993
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Remediation of prenatal alcohol effects with
acrobatic motor training
Number of slips
Klintsova AY., 1998
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Exercise reduces learning deficits
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Exercise improves hippocampal functioning
Open No exercise Dark Exercise
Electrophysiological response of hippocampal
cells
Cont PF Cont Ethanol
Christie et al, Eur J Neurosci, 2005
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• Voluntary exercise may enhance CNS plasticity and
  behavioral performance
• How does this translate into the clinical
  condition?

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• Multiple approaches (behavioral,
  pharmacological, nutritional) may provide the
  best treatment for FASD

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