Olfactory signal transduction in invertebrates

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Olfactory signal transduction in
invertebrates Johannes Reisert Department of
Neuroscience Johns Hopkins University School of
Medicine
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lobster silkmoth drosophila
3
Zhainazarov Ache, J Neurophysiol 1998
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Michel et al., J Neurophysiol 1991
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Boekhoff et al., J Neurosci 1994
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Boekhoff et al., J Neurosci 1994
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IP3 cAMP
Boekhoff et al., J Neurosci 1994
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Michel et al., J Neurophysiol 1991
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Michel et al., J Neurosci 1992
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R1
increase in cAMP
opening of a cAMP-gated K channel
hyperpolarisation
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Fadool Ache, Neuron 1992
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R1
R2
Gq
increase in cAMP
phospholipase C
opening of an cAMP-gated K channel
opening of a IP3-gated cation channel
hyperpolarisation
depolarization
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Zhainazarov Ache, J Neurophysiol 1998
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Zhainazarov Ache, J Neurophysiol 1998
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R1
R2
Gq
increase in cAMP
phospholipase C
opening of an cAMP-gated K channel
opening of an IP3-gated cation channel
Na influx
?
hyperpolarisation
opening of a Na-gated cation channel
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Riesgo-Escovar et al., J Comp Physiol A 1997
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Riesgo-Escovar et al., J Comp Phys A 1997
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Breer et al., Nature 1990
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Breer et al., Nature 1990
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Zufall Hatt, Proc Natl Acad Sci USA 1991
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Pophof van Naters, Chem Senses 2002
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Pophof van Naters, Chem Senses 2002
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maxillary pulp
antenna
Riesgo-Escovar et al., Proc Natl Acad Sci USA 1995
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Zufall Hatt, Proc Natl Acad Sci USA 1991
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Mutations of cAMP transduction pathway components
modify odor-induced responses (Martin et al.
200) Cyclic GMP levels and guanylate cyclase
activity in pheromone-sensitive antennae of the
silkmoth (Ziegelberger et al. 1990) IP3-activated
conductances (Stengl 1993) Adaptation depends
on the trp channel (Stoertkuhl et al. 1999)