Exercise physiology and Exercise testing

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Exercise physiology and Exercise testing
Mitochondrial DNA and Maximun Oxygen Consumption
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Index

• Introduction about this article
• General information
• 1º investigation
• 2º investigation
• 3º investigation
• 4º investigation
• Authors opinion
• Final conclusion

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Introduction about this article

• This article is about relationship
• between mitochondrial DNA
• and maximum oxygen consumption.
• 2. There are four different investigations.
• 3. The early researchers addressing
• the contribution of inheritance.

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General information
DNA Deoxyribonucleic acid (DNA) is a nucleic
acid that contains the genetic instructions used
in the development and functioning of all known
living organisms and some viruses. The main
role of DNA molecules is the long-term storage
of information
Different individual have different DNA
sequence. Morphs may account for some of the
differences including VO2 max.
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General information
Dna mitochondrial (mtDNA) is the DNA located
in organelles called mitochondria.

• Determinants of Maximal Oxygen Consumption
• Cardiac output
• The oxygen carrying capacity of the blood
• The amount of exercising skeletal
• muscle and the ability of muscle to utilize
  supplied oxygen

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1º investigation
Authors Dionne et al. Aim Association between
mitochondrial DNA sequences and aerobic
performance. Also they assessed the relationship
of baseline VO2 max and the response to
training. Process Endurance-training program
during 20 week. Subject 46 North Americans who
were sedentary. Results The subjects had a
morph in the gene encoding Subunit 5 of NADH
dehydrogenase. Conclusion Relationship to the
training responses of VO2 max.
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2º investigation
Authors Rivera and colleagues Aim Measure the
frequency of each of the three morph identified
within the NADH dehydrogenase and of one morph
of the D-loop. Subject 125 elite endurance
athletes and 65 sedentary. Results Dont found
difference in the frequency of these morph
between groups
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3º investigation
AuthorsChen et al, Ma et al. Aim A researches
focused on the D-loop, which contains factors
that the modulate mithocondrial DNA replications
and transcription. Subject A sample of 120
Chinese subjects 67 elite endurance athletes,
33 general endurance athletes, and 20 sedentary.
Results There were nine morphs, and their
frequencies were significantly different between
three groups. Conclusions This apparent
association between mithocondrial DNA D-loop
polymorphism and endurance capacity needs
confirmation. The authors suggested that a
better relationship might exist between the
mithocondrial DNA morphs endurance performance
rather than VO2max.
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4º investigation
Authors Melton et al. Aim Relationship between
mitochondrial DNA D-loop morphs and
VO2max. Subjects 40 well-trained Australian male
endurance cyclists. Results There wasnt
association between VO2max and the D-loop morphs
in this population of athletes.
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Authors opinion
The autors are in agreement with reports of
Dionne et al. (1991) and Rivera et al. (1998),
who found no significant relationship between
D-loop morphs and either sedentary VO2max or
elite endurance athlete status. The discrepancy
between these findings and those of Chen et al.
(2000) and Ma et al. (2000) may be related to
the ethnic differences between the subjects and
the small sample sizes do not allow firm
conclusions about the presence or absence of
small effects.
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Final conclusion

• There is evidence that V02max in athletes is
• limited by the ability to deliver oxygen to the
• muscles, rather than the ability of muscles.
• However, mithocondrial function
• could still be closely related to the
• trainability of VO2max in previously
• sedentary population and sub-VO2maximal
• endurance performance in athletes.

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JOSE MIGUEL PERUJO FRIAS PEDRO ALONSO TEJERO
SANTANA
THANKS FOR YOUR ATTENTION