Myofilament Substructure: CrossBridges

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Myofilament Substructure Cross-Bridges
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Myofilament Substructure Myosin

• Two identical heavy chains
• Several light chains
• Globular head
• Long slender neck and tail

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Myofilament Substructure Actin
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Sarcoplasmic Reticulum

• Hollow collar
• Both sides of Z line
• Extends to Z lines
• Regulates Ca2

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T Tubule

• Runs around perimeter at Z disk
• 0.1 µm in diameter
• Continuous with other tubules
• Lumen continuous with ECF
• Brings AP closer to cell interior
• Close to sarcoplasmic reticulum

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Muscle Anatomy

• Muscle cells
• Muscle fibers, Myofibers
• Long
• Cylindrical
• Multinucleated
• 5 to 100 µm in diameter

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Electron Micrograph of Sarcomere
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