Title: Biodemography of Human Longevity: New Methodological Approaches
1Biodemography of Human Longevity New
Methodological Approaches
- Dr. Leonid A. Gavrilov, Ph.D.
- Dr. Natalia S. Gavrilova, Ph.D.
-
- Center on Aging
- NORC and The University of Chicago
- Chicago, Illinois, USA
2General Approach
- To study success stories in long-term avoidance
of fatal diseases (survival to 100 years) and
factors correlated with this remarkable survival
success
3Centenarians represent the fastest growing age
group in the industrialized countries
- Yet, factors predicting exceptional longevity and
its time trends remain to be fully understood - In this study we explored the new opportunities
provided by the ongoing revolution in information
technology, computer science and Internet
expansion to explore early-childhood predictors
of exceptional longevity
Jeanne Calment (1875-1997)
4Revolution in Information TechnologyWhat does
it mean for longevity studies?
- Over 75 millions of computerized genealogical
records are available online now!
5Online Data Resources Used in These Studies
- Computerized genealogies
- Early U.S. censuses (1900, 1910, etc.)
- IPUMS (Integrated Public Use Microdata Series)
1 censuses - Social Security Administration Death Master File
- WWI civil draft registration cards
6Approach 1Using computerized genealogies
7Computerized genealogies is a promising source of
information about potential predictors of
exceptional longevity life-course events,
early-life conditions and family history of
longevity
8Computerized Genealogies as a Resource for
Longevity Studies
- Pros provide important information about family
and life-course events, which otherwise is
difficult to collect (including information about
lifespan of parents and other relatives) - Cons Uncertain data quality
Uncertain validity and generalizability
9For longevity studies the genealogies with
detailed birth dates and death dates for
long-lived individuals (centenarians) and their
relatives are of particular interest
- In this study 1,001 genealogy records for
centenarians born in 1875-1899 were collected and
used for further age validation
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11Internet Resources Used in Centenarian Age
Verification
- Social Security Administration Death Master File
is publicly available at the Rootsweb website
http//ssdi.rootsweb.com/cgi-bin/ssdi.cgi - Head of household indexes and census page images
for 1900, 1920 and 1910 federal censuses are
provided by Genealogy.com - Individual indexes of enumerated persons by 1900,
1920 and 1930 federal censuses and census page
images are provided by Ancestry.com
12Steps of Centenarian Age Verification
- Internal consistency checks of dates
- Verification of death dates linkage to the
Social Security Administration Death Master File
(DMF) - Verification of birth dates linkage to early
Federal censuses (1900, 1910, 1920, 1930)
13A typical image of centenarian family in 1900
census
14Results of Centenarian Age Verification
1001 records consistency checks 990 records used for further verification
990 records were linked to the SSA Death Master File Linkage success rate 77 (80 for centenarians born after 1890) In 3 of cases centenarian status was not confirmed
548 records found in DMF for persons born in 1890-1899 were then linked to early US censuses Linkage success rate 80 when using Genealogy.com and 91 after supplementation with Ancestry.com. In 8 of cases a 1-year difference between genealogy and census record was observed for birth year
15Conclusions of the Age Verification Study
- Death dates of centenarians recorded in
genealogies always require verification because
of strong outliers (10-20 years difference, 1.3,
misprints) - Birth dates of centenarians recorded in
genealogies are sufficiently accurate - 92 are
correct for the remaining 8 only one-year
disagreements - Quality of genealogical data is good enough if
these data are pre-selected for high data quality
16Study 1Compare centenarians found in
computerized genealogies with general population
17Case-Control Study of Early-Life Conditions and
Exceptional Longevity
Cases - 382 white households where
centenarians (born in 1890-1899) were raised
(from centenarian records linked to 1900
census) Controls 1 random sample of white
households with children below age 10 enumerated
by 1900 census (from Integrated Public Use
Microdata Sample, IPUMS http//www.ipums.umn.edu/
usa/index.html)
18Statistical Approach
- Logistic regression
- Dependent variable Households with child-future
centenarian (y1) vs control households (y0) - Predictor variables childhood residence,
household property status, paternal immigration
status, etc.
19Childhood Residence and Survival to Age 100Odds
for household to be in a centenarian group
- A New England and Middle Atlantic (reference
group) - B Mountain West and Pacific West
- C Southeast and Southwest
- D North Central
20Household Property Status During Childhood and
Survival to Age 100 Odds for household to be in
a centenarian group
- A Rented House
- B Owned House
- C Rented Farm
- D Owned farm
- (reference group)
21Paternal Immigration Status and Survival to Age
100 Odds for household to be in a centenarian
group
- A Father immigrated
- B Father native-born
- (reference group)
22No Association was Found (so far) Between Chances
to Become a Centenarian and
- Paternal literacy
- Child mortality of siblings
23Limitations
- Reporting bias in genealogies
- People mentioned in genealogies may be not
representative to the whole population - more fertile, longer-living (?), wealthier (?),
more educated (?)
24Study 2Compare centenarians with their
siblings (between-family study)
25Birth Order and Chances to Become a Centenarian
Cases - 436 centenarians born in the United
States between 1890 and 1899 Controls their
siblings born in the same time window (1,119
controls) Model log(longevity odds ratio) ax
bx2 cz d where x birth order z family
size a,b,c,d parameters of polynomial
regression model
26Birth Order and Survival to 100
Source Gavrilova, N.S., Gavrilov, L.A. Search
for Predictors of Exceptional Human Longevity.
In Living to 100 and Beyond Monograph. The
Society of Actuaries, Schaumburg, Illinois, USA,
2005, pp. 1-49.
27Study 3Compare centenarians with their
siblings (within-family study)
28Within-Family Study of Exceptional Longevity
Cases - 198 Centenarians born in U.S. in
1890-1893 Controls Their own siblings Method
Conditional logistic regression Advantage
Allows researchers to eliminate confounding
effects of between-family variation
29Design of the Study
30First-born siblings are more likely to become
centenarians (odds 1.8)
Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000
Variable Odds ratio 95 CI P-value
First-born status 1.77 1.18-2.66 0.006
Male sex 0.40 0.28-0.58 lt0.001
31Birth Order and Odds to Become a Centenarian
32Can the birth-order effect be a result of
selective child mortality, thus not applicable to
adults?
- Approach
- To compare centenarians with those siblings only
who survived to adulthood (age 20)
33First-born adult siblings (20years) are more
likely to become centenarians (odds
1.95)
Conditional (fixed-effects) logistic regression N797, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N797, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N797, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N797, Prob gt chi20.0000
Variable Odds ratio 95 CI P-value
First-born status 1.95 1.26-3.01 0.003
Male sex 0.46 0.32-0.66 lt0.001
34Are young fathers responsible for birth order
effect?
Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000
Variable Odds ratio 95 CI P-value
Born to young father 1.86 0.99-3.50 0.056
Male sex 0.42 0.29-0.59 lt0.001
35Birth order is more important than paternal age
for chances to become a centenarian
Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000
Variable Odds ratio 95 CI P-value
First-born status 1.64 1.03-2.61 0.039
Born to young father 1.29 0.63-2.67 0.484
Male sex 0.41 0.29-0.58 lt0.001
36Are young mothers responsible for the birth order
effect?
Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000
Variable Odds ratio 95 CI P-value
Born to young mother 2.03 1.33-3.11 0.001
Male sex 0.41 0.29-0.59 lt0.001
37Maternal Age at Persons Birth and Odds to Become
a Centenarian
38Birth order effect explainedBeing born to young
mother!
Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N950, Prob gt chi20.0000
Variable Odds ratio 95 CI P-value
First-born status 1.36 0.86-2.15 0.189
Born to young mother 1.76 1.09-2.85 0.021
Male sex 0.41 0.29-0.58 lt0.001
39Even at age 75 it still helps to be born to young
mother (age lt25)(odds 1.9)
Conditional (fixed-effects) logistic regression N557, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N557, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N557, Prob gt chi20.0000 Conditional (fixed-effects) logistic regression N557, Prob gt chi20.0000
Variable Odds ratio 95 CI P-value
Born to young mother 1.86 1.15-3.05 0.012
Male sex 0.46 0.31-0.69 lt0.001
40Conclusions
- Centenarians are more likely to be first-born
- The effect of first-born status is driven mostly
by young maternal age (lt25) at persons birth - Being born to young mother is an important
predictor of human longevity even at age 75
41Approach 2Using Social Security Administration
Death Master File
42What Is SSA DMF ?
- SSA DMF is a publicly available data resource
(available at Rootsweb.com) - Covers 93-96 percent deaths of persons 65
occurred in the United States in the period
1937-2003 - Some birth cohorts covered by DMF could be
studied by method of extinct generations - Considered superior in data quality compared to
vital statistics records by some researchers
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44Month-of-Birth and Mortality at Advanced Ages
- SSA Death Master File allows researchers to study
mortality in real birth cohorts by month-of-birth - Provides more accurate and unbiased estimates of
life expectancy by month of birth compared to
usage of cross-sectional death certificates
45Month of Birth Predicts the US Life Expectancy at
Age 80 Computed using the Social Security
Administration data
Source Gavrilova, N.S., Gavrilov, L.A. Search
for Predictors of Exceptional Human Longevity.
In Living to 100 and Beyond Monograph. The
Society of Actuaries, Schaumburg, Illinois, USA,
2005, pp. 1-49.
46Seasonality (month-of-birth effects) for
US life expectancy
47Approach 3Using Civil Draft Registration Cards
48Physical Characteristics at Young Age and
Survival to 100
A study of height and build of centenarians when
they were young using WWI civil draft
registration cards
49WWI Civilian Draft Registration
- In 1917 and 1918, approximately 24 million
men born between 1873 and 1900 completed draft
registration cards. President Wilson proposed the
American draft and characterized it as necessary
to make "shirkers" play their part in the war.
This argument won over key swing votes in
Congress.
50Information Available in the Draft Registration
Card
- age, date of birth, race, citizenship
- permanent home address
- occupation, employer's name
- height (3 categories), build (3 categories), eye
color, hair color, disability
51Draft Registration CardAn Example
52Data Sources
- Social Security Administration Death Master File
- WWI civil draft registration cards (completed for
almost 100 percent men born between 1873 and
1900)
53Study Design
- Cases men centenarians born in 1887 (randomly
selected from the SSA Death Master File) and
linked to the WWI civil draft records. Out of
120 selected men, 19 were not eligible for draft.
The linkage success for remaining 101 records was
75 (76 records) - Controls men matched on birth year, race and
county of WWI civil draft registration
54Height and Survival to 100
55Body Build and Survival to 100
56Results of multivariate study
Variable OR P-value
Tall and medium height vs short height 1.98 0.308
Slender and medium build vs stout build 9.96 0.032
Qualified jobs vs unqualified 1.57 0.300
Married vs unmarried 1.02 0.958
Natural born vs immigr. 1.12 0.782
57Conclusion
- The study of height and build among men born in
1887 suggests that rapid growth and overweight at
young adult age (30 years) might be harmful for
attaining longevity
58General Conclusion
- The shortest conclusion was suggested in the
title of the New York Times article about our
previous related study
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60Acknowledgments
- This study was made possible thanks to
- generous support from the National Institute on
Aging and the Society of Actuaries -
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