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Closing remarks and Q

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The ideal scenario for targeted agents. a single genetic abnormality that drives oncogenesis (e.g. bcr-abl in CML) ... No validated predictive markers for ... – PowerPoint PPT presentation

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Title: Closing remarks and Q


1
Closing remarks and QA
  • Denis Soulières
  • Centre Hospitalier de lUniversitéde Montréal,
    Montréal, Canada

2
Finding predictive markers in lung cancer
  • The ideal scenario for targeted agents
  • a single genetic abnormality that drives
    oncogenesis (e.g. bcr-abl in CML)
  • Lung cancer is an assembly of different diseases
  • multiple genetic changes
  • complicates the search for predictive markers
  • No validated predictive markers for chemotherapy,
    despite the associated life-threatening
    toxicities

3
Tarceva exchanging myths for facts
  • Treatment decisions must be based on robust
    evidence
  • For Tarceva, level 1 evidence is not available to
    guide patient selection in current clinical
    practice
  • Prospective and adequately powered trials are
    ongoing to address this important issue

4
Conclusions
  • Tarceva is a good option for second-line
    treatment of advanced NSCLC
  • similar efficacy to chemotherapy
  • better tolerability profile than chemotherapy
  • proven survival, symptom and QoL benefits
  • At this time, selection of patients to receive
    Tarceva is not validated
  • Results of ongoing studies should be awaited
    before denying patients access to this valuable
    therapy
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