A career in Industry:

1

• A career in Industry
• From Pharmaceuticals to
• Medical Devices
• Alan Clark

University of Edinburgh 9th November 2006
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Outline

• My career so far
• From Academia to Industry
• A career in Pharma
• From Pharma to Medical Devices
• About Stirling Medical Innovations
• Thoughts for your Career

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My career so far
1989
B.Sc. Hons. Biochemistry (4 years)
Academia
Ph.D. (3 years)
Postdoc. (2 years)
Project leader (6 years)
Industry
Cardiology Product manager
2006
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From Academia to Industry

• As a graduate in 1993, interviewed with big
  Pharma (Pfizer, Merck) but chose to do a Ph.D.
• Why?-Enjoyed research, wanted to own my project
• Risk of fewer openings in Industry when entering
  as a Ph.D./Postdoc but enter at a higher level
• In 1999, I was in the same position as you are
  now
• Joined Organon as a Senior Scientist in 1999

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Drug Discovery Process

• Target Discovery
• Identification and validation of biological drug
  target eg Ion channel implicated in disease.
• Lead Discovery
• Assay is developed for the selected target.
  Compounds are screened to determine whether they
  have any biological activity on the selected
  target. Compounds which are shown to have
  activity on the target are labelled as hits.
• Lead Optimisation
• Hits are optimised into lead compounds.
  Biostructural studies may also allow
  visualisation and optimisation of the compound's
  interaction with the target site to increase
  potency and selectivity. Successful compounds
  enter clinical development.

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Some aspects of Ion channel drug discovery

• Cell line generation
• Assay development
• Compound screening
• FLIPR/VIPR/Flexstation
• Calcium-sensitive dyes
• Membrane potential dyes
• Hit optimisation
• Electrophysiology
• Patch clamp

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A career in Pharma

• Hard work, high reward
• High compound attrition
• Focus on cycle time
• Opportunities for basic science (compound
  profiling /mechanism of action).
• Publication depends on sensitivity of subject
  matter.
• Career currency is high performance
• Organon was a good place to work and provided a
  good opportunity for personal development

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From Pharma to Medical Devices

• Needed a new personal challenge
• Big growth opportunity in Diagnostics sector
• Short product cycle times and faster learning
• Explore the interface between sectors
• Vision of Pharmacodiagnostics
• Stirling Medical Innovations is a unique and
  exciting company with big ambition-great place to
  work!

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About Stirling Medical Innovations

• SMI will be a world leader in research and
• development of advanced medical devices for the
• diagnosis and management primarily of chronic
• cardiovascular conditions.
• SMI is a subsidiary of Inverness Medical
  Innovations
• (IMI) group, a global leader in the development,
  manufacture
• and marketing of over-the-counter healthcare and
  rapid
• diagnostic products.
• Vision to create 500 jobs by 2010

www.stirlingmedical.com
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Cardiac Diagnostics
Coagulation Testing 450 million Market15
Growth in near patient testing
Congestive Heart Failure Diagnostics 250
million Market20 Growth
Cardiology Growth Drivers

• Cardiology conditions often require immediate
  intervention
• Ruling out MI as important as positive
  diagnostics
• Need for faster, cheaper, simple-to-use
  diagnostics
• Patients on anti-coagulants require regular
  monitoring

Acute Coronary Syndrome (Ischemia, D-dimer,
Troponin I, CKMB and Myoglobin) (1) 750 million
Market10 Growth
(1) Business Communication Company, Inc. (August
2004) Near patient testing
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Resources

• Investment
• Cardiology Research Center Stirling Medical
  Innovations Ltd
• 3 year, 130 million research project backed by
  parent company
• 30 million co-funded by ITI Life Sciences
• Both parties effectively share new IP created
  IMI owning the IP rights in the field of human
  healthcare and ITI owning the rights in all other
  fields
• RD Focus
• Novel biomarkers
• Home and near patient testing

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Talent

• Attract high calibre talent to Stirling
• Properly utilise and develop our talent
• Create an environment which encourages
  spectacular performance
• Reward our employees creatively based on company
  success
• Ongoing staff development to recruit, retain and
  motivate staff

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Clearly different, delivering transformational
cardiology products exciting the world and
enhancing life
VISION
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Thoughts for your Career

• Enjoy what you do and be proactive to get there
• Be courageous with self-belief
• Map your journey and stay focussed
• Your soft and hard skills determines your
  employability into industry
• Strive for continual personal development
• The job market is competitive -what qualities do
  you have to differentiate yourself from other
  candidates?
• See the big picture and identify trends
• Build external networks
• Stay open-minded to opportunities
• Maintain relationships
• Mentoring