Title: Challenges in the Primary Care Setting: Managing Renal Disease Health Disparities
1Challenges in the Primary Care SettingManaging
Renal Disease Health Disparities
Annual Leadership Summit on Health
Disparities Washington, DC, 26-27 April 2005
- Lawrence Agodoa, M.D.
- Director, Office of Minority Health Research
Coordination - National Institute of Diabetes and Digestive and
Kidney Diseases - National Institutes of Health
- Bethesda, Maryland
National Institute of Diabetes and Digestive and
Kidney Diseases
Department of Health and Human Services
2Health Disparities in the USBackground
- Health status affects quality of life, and,
ultimately, life expectancy. - The quality of life in the US, in general,
continues to improve. - Life expectancy for Americans significantly
improved in the 20th century. - The improved quality of life and longevity has
not been uniformly enjoyed by all Americans !
3Health Disparities
- Racial and Ethnic Minorities have, in general,
suffered disproportionately from severe diseases. - Chronic Kidney Disease and End Stage Renal
Disease afflict racial and ethnic minority
communities to a greater extent than in Caucasian
communities.
42005 Leadership Summit on Health
DisparitiesKidney Disease Health Disparities
Panel
- Introduction Magnitude of the Health
Disparities in Chronic Kidney Disease and End
Stage Renal Disease L. Agodoa - Complications and Management of Chronic Kidney
Disease and End Stage Renal Disease K. Norris - Treatment of Chronic Kidney Disease and End Stage
Renal Disease C. S. Modlin
5Time Trends in ESRD in the US
USRDS 2004 ADR
6Prevalent counts adjusted rates, by primary
diagnosis
illi
illi
lla
lla
December 31 point prevalent ESRD patients. Rates
adjusted for age, gender, race.
7Incident prevalent ESRD patient counts, by
modality
Incident ESRD patients December 31 point
prevalent patients.
8Number of incident point prevalent
patientsprojected to 2010
2002 prevalent count 431,284 (3.0)
Projected 418,600
Projected 111,300
2002 incident count 100,359 (-9.8)
9Medicare vs. non-Medicare spending
Medicare spending includes paid claims, estimated
Medicare Choice costs, estimated organ
acquisition costs. Non-Medicare spending includes
estimates of costs for EGHP patients for
non-Medicare ESRD patients, estimates of
patient obligations. See Appendix A for further
details.
10Adjusted Incidence Rates for ESRD by Race
Age and gender adjusted
USRDS 2004 ADR
11Racial Differences in Incidence of ESRD in
Children, Adjusted For Gender, 2000-2002
USRDS 2004 ADR
12Incidence Rate of ESRD by Race and Causes of
ESRD, Adjusted for Age and Gender, 1998-2001
13Challenges in Disparities in Kidney DiseaseKey
Questions
- What is the source of the growth of the ESRD
burden? - How likely are the at risk populations to go on
to ESRD? - How can we identify factors that promote racial
disparities? - What effective programs reduce the racial
disparities?
14Trends in Diabetic ESRD Incidence Rates per
Million Population Adjusted for age, gender and
race
Incidence per million population
Cohort Year
USRDS 2004
15Racial differences in ESRD
- What are the differences in incidence rates for
younger versus older patients entering with a
diagnosis of ESRD due to diabetes?
16Trends in ESRD Incidence Rates per Million
Population Adjusted for age, gender and race
Incidence per million population
Cohort Year
USRDS 2004 ADR
17Trends in ESRD Prevalence Rates per Million
Population Adjusted for age, gender and race
Prevalence per million population
Cohort Year
USRDS 2003 ADR
18Trends in the patients with diabetes as the
primary cause of ESRD
- Incidence rates for younger whites with diabetes
have fallen over the last 8 years - These findings may reflect improved care such as
better glycemic control and the use of ACE/ARBs
that are renoprotective - Incidence rates for blacks with diabetes have
dramatically increased at an almost linear rate
over the last 10 years - These findings may reflect an increasing
prevalence of hypertension - Poor blood pressure control
- Increasing prevalence of obesity
- Increasing prevalence of diabetes with poor
glycemic control
19Race and Chronic Kidney Disease Medicare
Population
20Racial differences in ESRD
- Access to care is less in the African American
population in Medicare compared to the White
population - To the extent diabetes and cardiovascular care
are associated with chronic kidney disease, the
African American population is under served - When access to care is taken into consideration
ESRD incidence rate decline from 3.5-4.0 to 2.11
times higher for African Americans vs Whites
21At Risk patients
- In order to address HP 2010 Objective 1, reduce
the rate of new cases of end-stage renal disease
(ESRD), one needs to define the at-risk
population that is likely to develop ESRD. A
special study by the USRDS to address this issue
utilized the Medicare system.
22Prevalence of Diabetes, OverallCDC BRFSS Report
2000 and 5 Medicare population
All adults
All Medicare adult patients (from claims)
Random phone survey
BRFSS - Behavioral Risk Factor Surveillance
System Mokdad et al, JAMA 2001, 2861195-1200
23Prevalence of diabetes, by raceCDC BRFSS Report
2000 and 5 Medicare population
All adults
All Medicare adult patients
BRFSS - Behavioral Risk Factor Surveillance
System Mokdad et al, JAMA 2001, 2861195-1200
24What is the likelihood of the at-risk populations
advancing to CKD, DM and ESRD?
25Incidence of ESRD during one year follow-up by DM
and CKD5 Medicare sample, 1997-1998 cohort
N1,265,831(25,316,620)
N1,711(34,220)
1.7
19.7
80.8
Entry period
ESRD during one year follow-up
26What is the likelihood of the competing event of
death in the at-risk population?
27Percent of patients who developed ESRD or died
during one year follow-up by DM and CKD5
Medicare sample , 1996-1997 cohort (RR Death vs
ESRD)
19,335
188,596
33,586
N1,045,263
0.03
0.11
1.27
3.40
RR 11.3
RR 66.7
RR 154
RR 5.04
DM/CKD
DM/Non-CKD
NDM/CKD
NDM/Non-CKD
Status in the entry period
28Percent of patients who developed ESRD or died
during two year follow-up by DM and CKD5
Medicare sample , 1996-1997 cohort (RR Death vs
ESRD)
19,335
188,596
33,586
N1,045,263
0.07
5.85
2.25
0.31
RR 10.9
RR 47.3
RR 134
RR 4.96
DM/CKD
DM/Non-CKD
NoDM/CKD
NoDM/Non-CKD
Status in the entry period
29Chronic Kidney DiseaseKey Questions
- What is the source of the growth of the ESRD
burden? Diabetes mellitus and hypertension are
the major sources for the growth of the CKD and
ESRD burden - How likely are the at risk populations to go on
to ESRD? Persons with diabetes and hypertension
are more likely to develop chronic kidney disease
and then progress to ESRD. However, the at risk
population is more likely to die than go to ESRD.
30Chronic Kidney DiseaseKey Questions
- How can we identify factors that promote racial
disparities? Racial and ethnic minorities are
disproportionately afflicted with diseases that
cause chronic kidney disease probably due to
multiple risk factors, including poorer access to
care, and other psycho-socio-economic disparities - What effective programs reduce the racial
disparities? Both public and private sectors
need to explore with innovative ideas to reduce
the disproportionate burden of kidney disease in
racial and ethnic minority communities.