LUTALYSE

1
LUTALYSE

• Amber McKee
• Emily Banaszak
• Fong Chau
• Steven Eckerman

2
Lutalyse, What is it?

• Produces luteolytic and/or oxytocic effects in
  cattle, horses, and swine
• In swine and cattle
• - induce parturition
• In cattle and horses
• - Controls time of estrus
• - Treat cows with functional corpus luteum but
  no behavioral estrus
• - Induce abortion

3
Hormonal Action

• Progesterone (dinoprost tromethamine)
• Utilizes metabolic pathways already in existence
• Imitates the animals diestrus phase
• Causes recession of the Corpus Luteum

4
Reproductive Uses

• Mares
• Controls time of estrous in estrous cycling mares
• Regresses corpus luteum in anestrous mares,
  resulting in estrous and ovulation
• Cattle
• Synchronization of estrous
• Treatment of unobserved estrous
• Termination of pregnancy

5
Chemical Class

• Lutalyse is classified as Prostaglandin F2 Alpha
• Prostaglandin is classified as a Eicosanoids
• Eicosanoids- are a group of substances that are
  derived from fatty acids.

6
The major acting chemical in Lutalyse is
prostaglandin
Body mechanism influence by prostaglandin
1.Constriction or dilation in vascular smooth
muscle 2. Regression of corpus luteum 3.Hormone
regulation -pituitary tropic
hormones a.
luteinizing hormone (LH)
b. Follicle-stimulating hormone
(FSH) 4.Constrict smooth muscle
-cause contract in uterus muscle 5. Involved in
the process of ovulation and gamete
transport 6.Regulate calcium movement
7.Snesitize spinal neurons to pain 8.Control
cell growth. -involve in skeletal
muscle synthesis. 9. Cause aggregation or
disaggreation of platelets 10.Regulate
inflammatory mediation
7
Protein Hormones (Ca2 Second Messenger)
GnRH
Plasma
Membrane
Phosphotidyl
Inositol
Receptor
G-protein
Receptor
DAG
R
Endoplasmic Reticulum
Secretory
Granules
Fusion
Plasma Membrane
LH
8
SIDE AFFECTS (in Animals)

• Increased Body Temperature
• Vomiting and Diarrhea
• Bronchial Constriction
• Confusion
• Loss of Coordination
• Low Blood Pressure
• Tachycardia