Review Article Acute Pulmonary Embolism

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Review Article Acute Pulmonary Embolism
Victor F. Tapson, M.D.
N Engl J Med Volume 358(10)1037-1052 March 6,
2008
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Summary

• Acute pulmonary embolism may occur rapidly and
  unpredictably and may be difficult to diagnose.
• Treatment can reduce mortality, and appropriate
  primary prophylaxis is usually effective.
• This review focuses on the pathogenesis,
  diagnosis, and treatment of acute pulmonary
  embolism of thrombotic origin.

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Outline

• Epidemiology and Pathophysiology
• Risk Factors
• Acquired Risk Factors
• Genetic Disorders and Thromboembolic Risk
• Diagnostic Approaches
• Clinical Manifestations
• Preliminary Laboratory Testing and Pretest
  Probability
• Imaging Studies
• Treatment
• Anticoagulation
• Placement of a Vena Caval Filter
• Treatment of Massive Pulmonary Embolism
• Complications of Thrombolytic Therapy
• Prognosis
• Prevention
• Pregnancy and Acute Pulmonary Embolism
• Conclusions

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Pathophysiology of Pulmonary Embolism
Tapson V. N Engl J Med 20083581037-1052
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Risk Factors for Venous Thromboembolism
Tapson V. N Engl J Med 20083581037-1052
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Clinical Prediction Scores for Suspected Acute
Pulmonary Embolism
Tapson V. N Engl J Med 20083581037-1052
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Contrast-Enhanced CT Angiograms Showing Acute
Pulmonary Embolism
Tapson V. N Engl J Med 20083581037-1052
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Diagnostic Approach to Suspected Acute Pulmonary
Embolism
Tapson V. N Engl J Med 20083581037-1052
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Treatment of Acute Pulmonary Embolism
Tapson V. N Engl J Med 20083581037-1052