CELLS

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RBC
RBC
CELLS
WBC
RBC
Fluid Matrix
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With Oxygen
Without Oxygen
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BLOOD
0
7
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VERY ACIDIC
NEUTRAL
VERY BASIC
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Blood Temp ? 100.4?F
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• Distribution
• Gases, nutrients, wastes.
• Regulation
• Body Temp., pH, body fluid volume, electrolyte
  levels.
• Protection
• Blood loss
• Pathogens

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Plasma
90
O2 , CO2
BUFFERS!
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Plasma Proteins

• Albumin (the most abundant one!)
• Made by liver
• Primary function is to maintain plasma osmotic
  pressure
• Also helps transport steroids and bilirubin

A
B
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Plasma Proteins

• Globulins
• Some are made by the liver
• Involved in transport of metal ions (e.g., Fe2),
  lipids, and fat-soluble vitamins.
• Others are made by plasma cells during the immune
  response
• These are antibodies.

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Plasma Proteins

• Clotting proteins
• Liver
• Fibrinogen, prothrombin, etc.
• Others
• Enzymes, hormones, others.

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Solution A
Solution B
10 drops of hydrochloric acid were added to
solution A and the pH changed by 4 units. 10
drops of hydrochloric acid were added to solution
B and the pH changed by 1 unit. Which solution
is the better buffer?
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Born in the red marrow
Circulate for 120d
Swallowed by a macrophage (usually in the spleen)
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Hemoglobin
Heme
Globin
Iron
Bilirubin
Carried by albumin to the liver
Carried by transferrin to the liver
Amino acids
Secreted into the small intestine as part of bile
Stored in the liver as hemosiderin or ferritin
Back into the plasma for reuse/recycling
Converted to stercobilin and urobilin and
excreted in feces
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ANEMIA
Low RBC Count
Low HB
Abnormal HB
Fe-Deficiency Anemia
Sickle-cell Anemia
Hemolytic Anemia
Aplastic Anemia
Pernicious Anemia
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Releases chemotactants
Damaged Cell
WBC
WBC
WBC
WBC
Release more chemotactants
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Never Let Monkeys Eat Bananas
Neutrophils Lymphocytes Monocytes Eosinophils Baso
phils
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Bacteria Killer!
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Histamine and Heparin
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Become macrophages
- Kill (T) - Antibodies (B)
- Communicate (T) - Coordinate (T)
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Hemostasis
Vascular Spasm
Platelet Plug
Coagulation
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Lumen
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Prothrombin Activator
Prothrombin
Thrombin
Fibrinogen
Fibrin
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Damage within the blood vessel
Damage outside the blood vessel
Extrinsic path
Intrinsic path
Prothrombin Activator
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Plasminogen
Plasmin
Fibrinolysis
Digests the fibrin clot
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Ca2
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