Folie 1

1
Sangrovit The innovative plant feed
additive General Aspects
2
In General

• Sangrovit.
• is a highly efficient, phytogenic feed additive
• naturally enhances feed intake, improves feed
  conversion and promotes health and vitality of
  animals
• can be used in all kind of animals

3
History

• Sangrovit was developed at University of Vienna
  at beginning of
• 1990 (Prof. J. Leibetseder, Dr. K. Neufeld)
• Question
• Evaluation of plant derived active substances,
  which are of interest for animal nutrition, as
  alternatives to AGP
• Result
• Benzophenanthridine-Alkaloids (Sanguinarine) were
  evaluated as one promising source (Sanguinaria
  canadensis)

4
History

• Sanguinaria canadensis
• high content of Benzophenanthridine-Alkaloids in
  the roots
• plant was used by the Indians as medical plant,
  because of their anti-inflammatory effects
• Colgate used a S. canadensis extract in tooth
  paste and oral rinses (because of their
  anti-inflammatory effects)
• Disadvantageous
• wild collection in Northern America
• limited amount
• price fluctuation

5
History

• in 2000 Phytobiotics started a cooperation with
  a Czech University
• Question
• Evaluation of plants, with same active components
  as S. canadensis, but which can be cultivated in
  Germany?

History
6
History

• Result
• Macleaya cordata has same active substances as
  Sanguinaria canadensis and can be cultivated in
  Germany.
• Advantageous of using Macleaya cordata
• Used parts aerial parts sustainable
  cultivation is possible
• Cultivation on own fields
• independent from the world market price
• direct quality control
• high transparency for our customers

7
Produced from one plant

• Macleaya cordata
• Active components
• Bitter substances
• Chemical group Benzophenanthridine-Alkaloids,
  with the main active principle Sanguinarine
• Sangrovit is standardized on 1.5 active
  substance !
• The use of these active substances in animal
  nutrition is protected by world wide patents.

8
Analyzable active components

• HPLC-Analyses (Kosina P. et al., 2003 High
  performance liquid chromatography and capillary
  electrophoresis determination of sanguinarine in
  biological matrices. J. Sep. Sci. 2003, 26,
  679685)
• Sanguinarine can be analyses in the plant, final
  product (Sangrovit), mineral feed, premixtures
  and compound feed
• This analyses is the basis for standardization,
  reliable research and consistent results in the
  field!

Chromatogram of Sanguinarine analyses in a
compound feed
---Feed without Sangrovit ---Feed with Sangrovit
9
Transparent production
10
Transparent production
11
Transparent production
12
Excellent and proven technical properties

• dust free micro-granulate
• excellent particle size distribution and thus
  easy and exact to dose
• stable against heat and acids
• stable during feed manufacturing processes as
  pelleting, extrusion,
• expansion
• stable during storage

13
Safe in use

• Active components of Sangrovit used since a long
  time in human applications
• Numerous different toxicological studies show
  Sanguinarine has a wide safety margin
• In house studies confirm Sangrovit is safe in
  use even in high over dosages!

14
All the Benefits at a Glance

• Pure, natural feed additive for all animal
  species
• Appetizing and digestive effect
• Improves feed utilization, relieves the
  metabolism
• Supports vitality and optimal animal performance
• Chemically defined and quantitatively
  determinable active ingredients
• Comprehensively tested for performance and safety