Biopharmaceutical Production in 1976 Porcine Insulin

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Biopharmaceutical Production in 1976Porcine
Insulin
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Biopharmaceutical Production in 1976Human Growth
Hormone
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Penicillin Production Paradigm

• Multi-disciplinary teams
• molecular, cell, and micro-biologists
• biochemical and mechanical engineers
• Three-pronged approach
• cells, medium, and bioreactor
• Progression of bioreactors
• surface culture on bottles to fed-batch
  suspension culture in deep stirred tanks
• Will it work for recombinant proteins?

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PRODUCTION OF RECOMBINANT PROTEINS
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Biotechnology Industry 2004

• Companies in U.S.
• 1500 companies, 39 billion in annual revenues
• 300 billion market capitalization
• Products in Clinical Trials
• 370 new indications, 10 approved per year
• Staff in U.S.
• 200,000 total employees
• maybe 1 in 500 have graduate degree in
  engineering from BPEC or similar program

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2004 Biopharmaceutical Production Engineered by
BPEC Graduate
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2004 Flu Vaccine Production(not engineered by
BPEC graduate)
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BPEC Flying Beaver Award for accomplishment
across all three planes-fundamental, technology,
system