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PRODUCT

• Composition
• Ceftiofur (as hydrochloride) .50 mg/ml
• Oil based vehicle qs.ad .. 1 ml
• Suspension for injection
• Target species
• Swine
• Cattle

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• Indications , Dosage and Administration
• Swine
• Treatment of bacterial respiratory disease
  associated with Pasteurella multocida,
  Actinobacillus pleuropneumoniae and Streptococcus
  suis.
• 3 mg /kg bw/day for 3 days by intramuscular
  injection, i.e. 1 ml of the product /16 kg
  bw/day.
• Cattle
• For the treatment of bacterial respiratory
  disease associated with Mannheimia haemolytica
  (former Pasteurella haemolytica), Pasteurella
  multocida and Haemophilus somnus.
• For the treatment of acute interdigital
  necrobacillosis (panaritium, foot rot) associated
  with Fusobacterium necrophorum and Bacteroides
  melaninogenicus (Phorphyromonas asaccharolytica).
• For the treatment of the bacterial component of
  acute post-partum (puerperal) metritis within 10
  days after calving associated with Escherichia
  coli, Arcanobacterium pyogenes and Fusobacterium
  necrophorum.
• 1 mg /kg bw/day for 3 to 5 days by subcutaneous
  injection, i.e. 1 ml of the product /50 kg bw/day.

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• Withdrawal Period
• Swine
• Meat and offal 2 days.
• Cattle
• Meat and offal 2 days
• Milk zero days.
• Packaging
• Bottle of 100ml
• Bottle of 250ml with a plastic package

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MARKET

• Semi sintetic penicillin is one of the most
  important antibiotic group
• Within this group, we can distinguish
• cephalosporin (including our EFICUR product)
• long acting amoxicillin
• other amoxicillin
• If we focus on cephalosporin, we find 3
  molecules
• Ceftiofur in different forms
• extemporaneous solution
• ready-to-use hydrochloride
• crystalline-free acid
• Cefquinome
• Cephalexin

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Cephalosporines market
Source Vademecum / Internal
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Uses for animal species
POULTRY SWINE CATTLE
Dairy
Meat
Source Veterindustria spanish market
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COMPETITORS

• Excenel RTU( Pfizer) is our main competitor, but
  we cant forget the other cephalosporines.

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• EFICUR against other market ceftiofurs (EXCENEL
  RTU Pfizer)
• Shorter withdrawal period
• 2 days ( meat) versus 5 days swine and 8 days
  cattle
• The only one with the 250 ml packaging, with a
  protector ( to avoid the bottle breaking).
• Better syringeability
• Average of 29,22 seconds vs 51,44 to expel 10 ml
  product

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• EFICUR vs cefquinome ( COBACTAN Schering)
• Shorter withdrawal period
• Cefquinome 2,5
• 2 days ( meat) versus 3 days swine, 5 days cattle
• 0 days milk versus 1 day
• Cefquinome L.A 7,5
• 2 days (meat) versus 13 days
• 0 days milk ( cefquinome L.A can not be used
  within 2 months prior to first calving in heifers
  intended for the production of milk for human
  consumption.
• The only one with the 250 ml packaging, with a
  protector ( to avoid the bottle breaking).
• Lower dosage per b.w ( cattle)
• 1ml / 50 Kg b.w/ day vs 1 ml / 25 Kg b.w/ day (
  2,5) and 1ml/ 30 kg b.w. ( 7,5) Their price
  per bottle is cheaper but the price for treatment
  is the same, even more expensive

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• EFICUR vs las cefalexin (CEPOREX Schering,
  SOLVASOL Norbrook)
• Shorter withdrawal period
• 2 days( meat) vs 4 days
• The only one with the 250 ml packaging, with a
  protector ( to avoid the bottle breaking).
• Indicated in swine
• Cefalexines are only indicated for cattle, cats
  and dogs
• Lowe dosage per b.w ( cattle)
• 1ml / 50 Kg b.w/ day vs 1 ml / 25 Kg b.w/ day
  Their price per bottle is cheaper but the price
  for treatment is the same, even more expensive

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1. Vial 250 ml and protector

• EFICUR is the only 250 ml cephalosporin marketed

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2. Withdrawal period

• EFICUR is the cephalosporin with shorter
  withdrawal period

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3. Syringeability

• Comparative of the necessary time to expel 10 ml
  of the product
• Utilization of one cristal syringa 10ml (
  fortuna Optima H) , needle de 17 G and a constant
  weight of 200g

Expel time ( seconds)
Average 51.44 sec
Average 29,22 sec
Repetitions