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Detecting Protein Function and ProteinProtein Interactions from Genome Sequences

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Putative Protein Interactions. Domain Fusion Analysis ... Putative Protein Interactions. 4290 protein sequences. 6809 pairs of nonhomologous sequences ... – PowerPoint PPT presentation

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Title: Detecting Protein Function and ProteinProtein Interactions from Genome Sequences


1
Detecting Protein Function and Protein-Protein
Interactions from Genome Sequences
  • TuyetLinh Nguyen

2
Outline
  • Putative Protein Interactions
  • Domain Fusion Analysis
  • Hypothesis for Evolution of Protein Interactions
  • False predictions

3
Putative Protein Interactions
  • 4290 protein sequences
  • 6809 pairs of nonhomologous sequences
  • Five candidates

4
Domain Fusion Analysis
  • First method uses the annotation of proteins
    given in the SWISS-PROT database
  • Second test of the interactions predicted by the
    domain fusion analysis uses as confirmation the
    Database of Interacting Proteins
  • Third test of domain fusion predictions is by
    another computational method for predicting
    interactions.

5
Hypothesis for Evolution of Protein Interactions
6
False Predictions
  • Physical interactions may be made by the domain
    fusion analysis
  • The domain cannot distinguish between homologs
    that bind and those that do not

7
Conclusion
  • Genomics information opens new paths to
    biochemical discoveries.
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