Rabies, the Fury Virus

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Rabies, the Fury Virus
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Pathogenesis

• Bite site
• striated muscle cells
• peripheral nervous system is exposed in
  neuromuscular spindles
• exposed sensory nerve endings and motor end
  plates

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Pathogenesis (cont)

• Neuronal infection (towards the center)
• CNS
• Brain and Salivary Glands

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Why it is so evasive

• There may be very little virus and virus antigen
  delivered to evoke an immune response
• There may be very little virus and virus antigen
  produced in muscle early in the infection and
  very little in the peripheral nerves and CNS .

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Why it is the fury disease

• Virus enters the saliva an multiplies
  exponentially at the same time it causes a fury
  effect in the limbic system.

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End result

• The virus enters the neocortex.
• Causes the dumb stage
• Death by respiratory distress

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Control

• Immunization
• currently spend 1 billion dollars in U.S. alone
• looking for more effective drugs

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