HOW CAN CRANBERRY JUICE CONSUMPTION HELP PREVENT HEART DISEASE

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HOW CAN CRANBERRY JUICE CONSUMPTION HELP PREVENT
HEART DISEASE?

• Ted Wilson, Ph.D.
• Department of Biology
• Winona, MN

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How diet affects heart disease
I) Cardiovascular Disease the Diet-Disease
Connection and the French Paradox. II)
Cranberries Contents Should Prevent
Cardiovascular Disease. A) CBJ Inhibit LDL
Oxidation B) CBJ Promotes Vasodilation
C) CBJ Inhibits Blood Clotting III) Future Goal
is to Prevent Heart Disease with Cranberry
Products.
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Cranberry Juice Inhibits the Oxidation of Low
Density Lipoprotein Very Effectively at dilutions
of 11,000, 15,000 and 115,000

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TBARS IN CU OXIDIZED LDL IN THE PRESENCE OF
EIGHT CRANBERRY CULTIVAR EXTRACTS AT 15,000
DILUTION. 1Crowley-Brandon, OR,
2Stevens-Brandon, OR, 3Stevens-Nantucket,
4Ben Lear-Nantucket, 5Ben Lear-Warrens, WI,
6Stevens-Warrens, WI, 7Stevens-Manitowosh
Waters, WI, 8Ben Lear-Manitowosh Waters, WI

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Polyphenolic contents of cranberry extracts used
in assays

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Cranberry sauces protect LDL against oxidative
stress at a 11,000 dilution
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Cranberry sauces partially protect LDL against
oxidative damage at a 15,000 dilution
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Correlation of potential antioxidant capacity
with cranberry sauce polyphenol content
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Cranberry Juice Vasodilates (Relaxes) Isolated
Rat Arteries by Stimulating Nitric Oxide
Synthesis from the Healthy Endothelium.

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Cranberry Juice Vasodilates the Rat Circulatory
System In Vivo.

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CBJ Consumption by Humans May Affect Vascular
Resistance in the Arm. When peak flow velocity is
compared from the left (pre) to the right side
(post-cuff), peak flow increased by 45. More
imortantly the shape of the flow-curves has
changed, and the smaller peak just after point
A was 21.8 cm/sec for the pre-cuff flow and
this increased to 69.9 cm.sec (a 320 increase).
This suggests that CBJ dramatically decreased
peripheral resistance and increased blood flow.
Blood FlowPre-Blood Pressure Cuff
After
Cuff Removal

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Cranberry Juice Consumption Appears to Inhibit
Blood Clotting in Humans.

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What health benefits do cranberry products appear
to provide?

• 1) Juice contains antioxidants
• 2) Juice may provide vasodilators
• 3) Juice may inhibit clotting
• 4) Sauce contains similar polyphenolic compounds
• 5) Sauce contains antioxidants

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Why Should CBJ be a Part of a Heart Healthy Diet?
Familiarity with Red Wine and Concord grape
juice as heart smart beverages. Recognition that
alcohol and sugar content may be
unsafe. Recognition of CBJ as an alternative
heart healthy beverage. Ability to promote
cardiovascular health with cranberry products.
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How does cranberry research get to the consumer?
Peer Reviewed Publications Newspaper
Articles Stories in popular Magazines. T.V. Wo
rd of mouth in health conscious consumers.
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Several people and organizations have helped make
this ongoing research possible.Remember to drink
your cranberry juice!

• Margaret Maher, Ph.D.
• John Porcari, Ph.D.
• Richard Backes, M.D.
• Scott Marshall, M.D.
• Cathy McNamara RT
• Jason Marley
• Sara Staupe
• Tiffany Niskala
• Matt Roth

• Funding From
• Cranberry Institute
• Wisc. Cranberry Board
• Northland Cranberries
• U.S. Department of Agriculture

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Publications of Interest

• Maher, M.A. et al. (2000) J. Med Foods. 3141.
• Wilson, T. et al. (1998) Life Sci. 62381-386.
• Wilson, T. et al. (1999) J. Nutraceut. Funct.
  Foods. 25.
• Wilson, T., Marley J. (2001) FASEB J. 15A286.
• Tentative Wilson, T. et al, (2004) FASEB J.
  Abstract