EORTC Virtual Tumor Bank VTB

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EORTC Virtual Tumor Bank (VTB)
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EORTC Tumor Bank

• Tumor Bank Steering Committee, which is composed
  of representatives of the EORTC Pathology Group
  and EORTC Data Center
• Wolter Oosterhuis, EORTC Tumor Bank, chairman
• Alain Spatz, EORTC Pathology group, chairman
• King Lam, EORTC Pathology sub-committee group for
  Telematics, chairman
• Peter Riegman, pathologist and assistant project
  leader of the TuBaFrost Project, Erasmus Medical
  Center, Rotterdam
• Ivana Teodorovic, EORTC Tumor Bank Coordinator,
  EORTC Data Center
• Martin Isabelle, EORTC Tumor Bank Administrator
  (TBA), EORTC Data Center
• EORTC IT unit (Pascal Ruyskart, Yves Dohogne and
  Eric Decossaux)
• EORTC Legal Advisor
• Pilot phase project sponsored by Parthenon Trust
  (Sept 2000- Sept 2003)

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EORTC Tumor Bank - Aims

• To standardize and support histology review
  across EORTC trials (quality of research)
• Create tumor bank
• Real tumor bank (centralized storage of paraffin
  embedded tissue blocks and glass slides
  stained/unstained at the EORTC Data Center)
• Virtual tumor bank (information and histological
  images on centralized and decentralized stored
  material)
• Legal issues
• Access and use
• Facilitate translational research (by making
  biological material available to scientists)

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Histology review
Virtual tumour bank and real tumour bank
Tumor banking
Translational research
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Real Tumor Bank (EORTC Data Center)
Glass Slides
Paraffin Embedded Tissue Blocks
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Material and Data Flowchart during histology
review
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Support for Translational Research within EORTC
protocols
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Patient information Sheet/Informed consent
(PIS/IC)

• in case of optional research on biological
  material separate documents for clinical PIS/IC
  and the one related to translational research
• in case of mandatory research on biological
  material within a clinical trial, only one PIS/IC
  covering both aspects
• explanation about research on biological material
  must be clear and transparent and should include
• information about possibility to reveal any kind
  of hereditary nature of disease
• protection of patient rights and identity
• benefits for research
• voluntary aspects
• in case of optional research
• in using material for future cancer research
• on sending the material to a third party
• agreement for an additional tissue sampling
• explanation about intellectual property rights

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Virtual Tumor Bank (VTB) - Goals

• Design and construction of a pathology database
  for pathology and material data and a link to the
  EORTC clinical database
• Construction of a website (Virtual Tumor Bank) to
  allow users to access patient's pathology,
  clinical and material (including images) data
  online and allow online pathology review to take
  place.
• Construction of an online search engine to allow
  researchers to search for tissue material, view
  tissue information (including images) and check
  on tissue availability for their research
  projects.

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Virtual slides can be produced from the glass
slides collected and stored with the tissue
records within the VTB. This will support
histology review and provide further assistance
to researchers.
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Virtual Tumor Bank
Panel Review (if required)
Panel Chairperson (PC)
VISTADATABASE
VTBDATABASE
VTB System
Panel Member (PM)
Panel Member (PM)
Panel Member (PM)
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Current Tumor Bank Project supported trials/groups

• GU Group (30993 30994)
• Gynecological Cancer Group (55994 and 55012)
• GI Group
• STBSG Group (62005)

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Future hopes and goals for the EORTC Tumor Bank
and TuBaFrost

• Short Term
• use the VTB for central access to decentralised
  collections of frozen tissues in further
  EORTC-affiliated institutions
• prospectively collect paraffin blocks of all
  patients entered in an EORTC trials
• make the existing collections of material
  available to investigators for translational
  research
• engage EORTC-affiliated OECI institutions in
  building up collections of frozen tissues of
  patients entered in EORTC trials
• submit a follow up project for TuBaFrost in the
  6FP in collaboration with the OECI
• select one Pathology Lab to do the lab work for
  the Tumor Bank at the DC the lab of Erasmus MC
  would be a good candidate in view of its current
  role in the VTB and the TuBaFrost Project
• set up a Charitable Trust in collaboration with
  the OECI
• Long Term
• purchase a machine to make tissue micro-arrays at
  the DC and make virtual slides of tissue
  micro-arrays and of the experimental results
  obtained with them
• create a small lab at the DC for cutting paraffin
  blocks and staining slides with H and E
• make tissues available to the research community
  and the private sector through the Charitable
  Trust, on a not-for-profit basis

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Screenshots of the Virtual Tumor Bank (VTB) System
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EORTC Tumor Bank Website www.eortc.be/vtb/tumor
bank