Ranolazine: Long-term use

1
Ranolazine Long-term use
Exercise-induced chronic angina Successfully
completed 1 of 2 treadmill studiesN 746
Open label Ranolazine titrated to 1000 mg
bid 2.96 years mean follow-up
Results Overall mortality 2.8 per
patient year (PPY) SCD mortality 0.6 PPY QTc
gt500msec 10 patients Torsade de Pointes 0
patients Ranolazine discontinuation due to AEs
9.7 in first 2 years Age gt64 years and prior Hx
of HF were significant predictors of
AE-associated discontinuation
Koren MJ et al. J Am Coll Cardiol. 200647(suppl
A)Abstract 999-253.
SCD sudden cardiac death