Presentaci

1
1. ETIOPATHOGENIC BACKGROUND
Genetic background
Neurohormonal factors

3. ESTABLISHMENT
T-cell dysfunction
B-cell hyperractivity
2. INITIATION
Autoantigens Viruses
4. PERPETUATION

• cytokines
• chemokines

Apoptosis Altered epithelial repair Proteolysis
5. EPITHELIAL DAMAGE
2
Epithelial physiological balance
Apoptosis
Repair


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Pro-repair signals
Pro-apoptotic signals
Anti-apoptotic signals
Fas/FasL TNFa/ TNFa-R TRAIL/TRAIL-R PD-1/PD-1L Bax
Caspase-3 Granzyme B IFN?
Bcl-2 cFLIP PARP XIAP p53 p21
TFF-peptides (Trefoil proteins) TFF-1
(pS2) TFF-2 (SP) TFF-3 (ITF)
Therapeutic approaches
Blocking
Stimulating
Stimulating