Autism

1
?????? Autism

• ????? ???????? ???? ??????
• ???????? ????? ????? ??? ???????

2
????? Definition

• ???? ?????? ?
• ?? ?????? ???? ?? ????? ?????? ???? ??? ????
  ??????? ? ??????? ????????? ???? ?????
  ?????? ? ?????? ??????? ????? ? ????? ???????
  ?????? ? ??????
• ? ???? ??? ???????? ???? ??? ???? ????? ??????
  ??? ??? ?? ???? ?? ????? ?? ?? ????
• ????? ???? ???? ?????? ? ?? ???? ???
• ?? ??? ???? ?????? ? ??? ???? ?? ???? ??????? ??
  ???? ??????? Childhood chizophrenia
• Or childhood psycosis

3

• ??? ?? ??? ?????? ?????? ?????? Kanner ??? 1943
• ???? ?????? ???????? 1-2/1000 ?? ????? ???????
  ????? ????? ?????? ????? pure autism ?? ???????
  idiopathic ???? 4/10 000
• ????? ?????? 4/1
• ????? ????? ??? ??? 3 ?????
• ???? ???? ?????? ? ???????
• ?? ????? ?? ??????? ?????????? ?? ???????? ??
  ??????????

4
??????? Causes

• ?? ???? ????? ???? ???? ???? ?????? ? ??? ????
  ???????? ???????? ? ???? ???? ????? ? ??????? ??
  ??? ???? ???????? ?? ??????? ???????
• ??????? ??????? ?? ??????
• - ???? ????? ?????? 11 ???????
• - ?????? ???? ???? ?????? ??? ??????? ????????
  ????????? ?? ??????? ?????? ?????? ( 60 )
• - ????? ???? ???? ?????? ??? ???? ?????? ??? 30
  
• ????? ??????? ?????? ?? ????????

5
Neurobiology

• MRI cerebral ???? ?????? ???????? ?? 25
• Functional MRI (SPECT )
• ??? ????? ???? ????
• ??? ??????? ?????? ??? ??? ????? ?????? ??????
  ????? ??????? ?????? ??????? ? ????? ??????
• ??? ?????? ?????? ?? ??????? ???????
• Neurochemistry hyper-serotoninemia
• hyop- noradrenaline
  dopamine
• ?????
  ?????? B-endorphines
• Neuropathologyhyppocamp amygdale atrophy
• ??? ?????
  purkinjy ?????? ???????

6
Symptomes

• ???? ??? ???? ?? ????????? ???????? ???? ????????
  ????? ??????? Autistic spectrum disorders
• ?????? ??????? ?? ???????? ????? ???????? ?????
  ?? ???? ???? ?? ??????? ??? ????? ????? ????????
  ????????? ? ???? ??? ???? ?? ???? ???? ????
• ??????? ?????? ??????? ???? ????? ??????
• 1- ??? ???????? ????????? impairment in social
  interaction
• 2- ?????? ??????? communication disorder
• 3- ?????? ?????? behavioral disorder

7
Symptoms

• ??? ?? ????? ??????? ?????????
• - ????? ???????? ????? ?????? ?????? ????? ?? ??
  ????
• - ???? ?? ????? ?????? ???????? ?????? ?? ????
  ????? ????? ????
• ?? ????? ????? ????? ???? ?? ??? ??????
• ???? ???????? ???????
• ???? ??????? ??????

8
Symptoms

• ?????? ??????? Communication disorder
• ?? ???? ???? ???? ??? ???? ( ????????? ?
  ??????????? )
• ?? ???? ????? ??? ???????? ??????? ???? ??? ?
  ???????
• ???? ??????? ??? ?????? ???? ????
• ??????? ????? ??????? ???? ?????? ???? ?????
  monotone
• ??????? ??? ?????? ?? ????? ?????? ?? ????
• ?? ????? ???????? ????? ?? ????? ?????
• ?????? ??????? ??????? ??? ??????? ?????????
• ?????? ?? ????? ???? ???

9
Symptoms

• ?????? ?????? Behavioral disorder
• ???? ??? ?????? ?? ???? ????? ?? ????? ???? ???
  ?????
• ????? ????? ? ????? ?????
• ???? ?????? ?? ??????? ?? ?????? ??????
• ??? ???? ??????? ???? ??? ??????
• ??? ?????? ?????? ????? ?????? ?? ????? ??
  ?????
• ?????? ??????? ??????
• ????? ?????? ??????? ???? ????? ???? ????
  ?????? ?? ??????? ???????
• ??? ?????? ? ?????? ???? ??????? ???? ????
  ???????- ???????

10
?????????? ?? ??????

• ???? ??? 33 ?? ?????????
• ???? ?????? ???? ????? ?????? ?? ??????
• ???? ????? ??? ?????
• Atonic- tonic partial complex spasm infantile
• ?????? ????? ??? ?????? ???????? ?????????
• ?????? EEG ????? ??? 60 ?? ?????????

11
?????? ?? ??????

• IQ
• 50 ??? 50
• 50 70 ??? 20
• 70- 100 ??? 30
• ????? ??????? ???? ????? (????????? ????????) ?
  ???? ???????? ???? ???? ? ????? ?? ???? ????
  ??? ??? ?????? ????? - ???????
• ??? ???? ??????? ????????? ???????? ???????

12
???? IV DSM???????? ????????? ??????
Diagnosic Statistical Manual of Mental
Disorders 1996
13

• ???? 6 ?? 12 ???? ??? ????
• ?? 2 ?? ?????? A 1 ?? ??????B 1 ?? ?????? C
• ??????? ????? ? ??? ?? ???? ??? ?? 3 ????? ???
  ?????? ?? ???? ??? 18 ???

14
???????? ??????? ??????

• ??????? ???? ??? ?????? ???? ????? ??? ???????-
  ????? ?????- ?????? ??? ????? ?????
• ?????? ???? ??????? ???????? ??????? ??????
  ?????? ????? ??? ?????? ???? ??? ????
• ???? ????? ?? ??????? ?? ???????? ???? ????
• ??? ??????? ??? ?????? ( ?????? ??????? ????
  ??????? )
• ?????? ??????? ?????? ???? ????????
  ???????-???? ????? ???? ?? ???? ????? ??
  ???????? ??????? ??????? ????? ?? ??????

15
When we call doctor?

• List of 5 behaviors according of (NICHD)
• 1-does not babble or coo by 12 months
• 2- does not gesture (point-wave-grasp) by 12 m
• 3-does not say single words by 18 months
• 4-does not say two-words phrases by 24 months
• 5- loss of any language or social skills at any
  age

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????????? ? ??????? ????????? ?? ??????

• Aspergers syndrome ???? ????? ???? ????????
  ????? ?? ???? ????
• Rette syndrome ???? ??????- ????? ???????
  ??????? ???????
• X-fragile syndrome ???? ????? ?? ???? ????
• Tuberous sclerosis (Bourneville disease)
• Encephalitis- congenitl rubella- untreated PKU
• ?????? ??????? ???????

17
Managements

• ????? ?????? ????? ???? ??? ?????? ? ?????? ?????
  ???? ??????
• ????? ???? ????? ?? ??????????? ?? ????????
  ???????
• ????? ????? ????? ??? ??? ????? ?????
  ?????? ?????? ??? ????? ??????? ? ?????
• ???????? ???????? ? ???? ??????? ???????
• Stimulants (methylphenidate) ,antidepressants,
  antipsychotics, opiate blockers ,tranquilizers
  and antiepileptics.

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(No Transcript)
19
Prognosis

• ????? ?????? ??? ???????? ?????? ????? ???????
• ??? ???? ???? ?? ??????
• ???????? ???????? ??????? ? ???????? ???????
  ???? ?????? ?? ????? ???? ????? ?????? ? ????
  ??????? ????????
• ????? ???? ?? ??????? ????????? ?? ??????
  ???????? ???? ??????? ? ??????? ? ???? ?????? ??
  ???? ?????? ?? ??????? ? ???? ????? ???? ??????
  ???? ?? ???? ????? ??? ????? ? ????? ????

20
What ?!
Thanks