ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND REMODELING

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ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND
REMODELING
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ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND
REMODELING

• Cell deformation

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ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND
REMODELING

• Cell deformation
• Cell membrane response (ion channels, receptors)

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ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND
REMODELING

• Cell deformation
• Cell membrane response (ion channels, receptors)
• Intracellular signaling

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ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND
REMODELING

• Cell deformation
• Cell membrane response (ion channels, receptors)
• Intracellular signaling
• Intercellular signaling

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ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND
REMODELING

• Cell deformation
• Cell membrane response (ion channels, receptors)
• Intracellular signaling
• Intercellular signaling
• Cellular adaptations

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MECHANICAL STIMULI
METABOLIC STIMULI
Blood flow Shear stress Wall tension Stretch
Ischemia/hypoxia Increased flow
Cell
receptors
Ion channels
ECM
Growth factors cytokines
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Intercelluar signaling in response to mechanical
signal
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ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND
REMODELING
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ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND
REMODELING

• Meininger Mechanical factors and arteriolar
  remodeling ECM and Integrins (VSM)

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ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND
REMODELING

• Meininger Mechanical factors and arteriolar
  remodeling ECM and Integrins (VSM)
• Langille Vascular growth and remodeling
  (endothelial cells)

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ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND
REMODELING

• Meininger Mechanical factors and arteriolar
  remodeling ECM and Integrins (VSM)
• Langille Vascular growth and remodeling
  (endothelial cells)
• Zheng Stretch-induced growth factors in coronary
  vasculature (growth factors and receptors)

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ROLE OF MECHANICAL FACTORS IN VASCULAR GROWTH AND
REMODELING

• Meininger Mechanical factors and arteriolar
  remodeling ECM and Integrins (VSM)
• Langille Vascular growth and remodeling
  (endothelial cells)
• Zheng Stretch-induced growth factors in coronary
  vasculature (growth factors and receptors)
• Brown Physical forces and capillary growth in
  skeletal muscle (internal and external forces)