Mature DC

1
Antigen capture
B cell expansion
Immature DC
T cell expansion
PAMP recognition and activation
Mature DC
Figure 1. DC activation and maturation. Adapted
from Wack, A. and Rappuoli, R. Current Opinions
in Immunology 2005
2
Figure 2. Human DC subsets and lineage origins.
Shortman, K and Y. J. Liu Nature Reviews
Immunology 2002
3
Figure 3. Within the immune synapse formed
between APCs and T cells, three signals are
required for antigen-specific T cell activation.
Gutcher, I. and Becher, B. Journal of Clinical
Investigation 2007
4
Figure 4. APC-derived cytokines guide the
differentiation of naive T cells into an effector
T cell subtypes in mouse. Gutcher, I. and
Becher, B. Journal of Clinical Investigation 2007
5
Figure 5. Structures of the IL-1R family. Sims,
J. et al Current Opinions in Immunology 2007
6
Table 1. Synthetic and endogenous TLR
ligands. Kanzler, H. et al Nature Medicine 2007
7
Figure 7. IRF Activation by Cytosolic
Pattern-Recognition Systems Operation of a
Positive-Feedback Mechanism. Honda, K. et al
Immunity 2006
8
Figure 8. Summary of TLR signaling pathways.
Dunne, A. and ONeill, L. FEBS Letters 2005
9
TRIF
TRIF
TBK1 IKKe
Figure 9. Type I IFN positive feedback loop.
Adapted from Doyle, S. et al, Immunity 2002
10
Figure 10. Schematic representation of IRF-3 and
IRF-7 activation and dimerization by
virus-induced phosphorylation. Lin, R. et al.
Cellular and Molecular Biology 1999
11
Figure 11. Enhanceosome formation and IFN-ß gene
transcription. Kenya, H. et al Immunity 2006
12
Figure 12. IL-12 family members composition,
receptors and regulatory functions. Adapted
from Goriely, S. and Goldman, M. Transplantation
2007
13
IL-23
IL-27
Figure 13. Regulatory functions of IL-27. Adapted
from Colgan, J. and Rothman, P. Nature Immunology
2006
14
Figure 14. The classification and structure of
the PKC family of isozymes. Kheifets, V. and
Mochly-Rosen, D. Pharmacological Research 2007
15
Figure 15. Model of PKCa phosphorylation.
Bornancin, F. and Parker, P.J. Journal of
Current Biology 1996
16
Adapted from
TLR3
PKCa
IL-12/23p40 IL-23p19
IL-12p35 IL-27p28
Figure 16. Schematic of PKCa activity in TLR3 and
TLR4 signaling pathways. Adapted from Akira, S.
and Takeda, K. Nature Reviews Immunology 2004