Title: Nanobiotechnology and Global Health:
1 - Nanobiotechnology and Global Health
- Opportunities, Paradoxes, Integration
- Mauro Ferrari, Ph.D.
- Professor, Brown Institute of Molecular Medicine
- Chairman, Biomedical Engineering Department
- University of Texas Health Sciences Center,
Houston - Professor, Experimental Therapeutics MD Anderson
- Adjunct Professor, Bioengineering, Rice
University - Adjunct Professor Biomedical Engineering UT
Austin - President, Texas Alliance for NanoHealth
AIMBE, Washington DC, Feb 21 2008
2Three main parts
- History and Bioethics / Philosophy
- Nanotechnology examples
- Early detection from biofluids
- Sustained release therapeutic nanosystems
- Imaging contrast at low field
- Directed delivery / bio-barrier avoidance
- Models of Collaborative Research, Development and
Deployment - (The unspoken elephant Financial drivers?)
3Nanotechnology and Global Health
- Human Development Report, UN Development Program,
2001 emphasis on tech, but no mention of
nanotech - UN Meeting on Nanotechnology Gap, Trieste 2003
- UN Task Force on Science, 2005 Technology and
Innovation potential of nanotechnology for
sustainable development - Nanotechnology and the Developing World,
Salamanca-Buentello F, Persad DL, Court
EB, Martin DK, Daar AS, et al. (2005)
Nanotechnology and the Developing World. PLoS Med
2(5) e97 (Peter Singer)
4Nanotechnology and Global Health
- February 27, 2007 Using Nanotechnology to
Improve Health Care in Developing Countries
Washington DC (convergence of two Woodrow Wilson
International Center Pew Foundation efforts
the Project on Emerging Nanotechnologies and the
Global Health Initiative). - Singers proposed initiative Addressing Global
Challenges Using Nanotechnology. - Modeled after the Foundation for the NIH/Bill and
Melinda Gates Foundation's Grand Challenges in
Global Health, the initiative would be funded by
national and international foundations, and from
collaboration among nanotechnology initiatives in
industrialized and developing countries.
5Singer study (PloS 2005) survey of 63
nanoscientists from around world
- Question Which do you think are the
nanotechnologies most likely to benefit
developing countries in the areas of water,
agriculture, nutrition, health, energy, and the
environment in the next 10 years? (see 2002 UN
Johannesburg Summit on Sustainable Development). - Criteria
- Impact
- Burden
- Appropriateness
- Feasibility (10 years)
- Knowledge gap
- Indirect benefits
6Correlation between the Top Ten Applications of
Nanotechnology for Developing Countries and the
UN Millennium Development Goals (from Singer et
al, 2005)
7Prioritized Health Care Applications of
Nanotechnology for Developing Countries (from
Singer et al 2005)_
8Bioethical framework (my personal views)
- Science and Society Kyoto 2005
- University of Minnesota Law School Ethics and
Nanotechnology May 19 2006 - Presidents Council on Bioethics June 29 2007
9A Beauchamp-ChildressFrame of Reference for
Medical Ethics
- Beneficence (Do The Most Good)
- Non-Maleficence (Do No Harm)
- Respect (Autonomy, Self-Determination, Human
Nature) - Justice (Equal Access)
10Considerations on Beneficence What good can
medical nanotech do?
- Progress in
- Risk assessment
- Mass screening
- Early detection and treatment
- Increased treatment efficiency
- Personalized diagnostics therapy
- Reduction of undesired side effects
- Reduction in cost of medical care
- Increase in access to medical care
11Barriers to deployment of beneficial potential of
medical nanotech
- Insufficient scientific progress
- Delay in evolution of multidisciplinary
perspective - Delay in development of regulatory framework
- Delay in engagement of private sector
- Delay in education of practitioner base
- Delay in development of reimbursement protocols
- Insufficient/delayed engagement of stakeholders /
general population - Insufficient/delayed focusing on global health
12On Non-Maleficence (First
Do No Harm)
- Harm is potentially done by
- Not developing effective diagnostic/screening
tools and prevention or therapeutic approaches
that we are in a position to attain (Opportunity
Cost) - Treating when the suffering due to treatment
exceeds the benefits to the patient, in his/her
assessment - Device/system malfunction
- Causing health problems in health care provider,
non-patient population (e.g. environmental impact
of therapeutic/diagnostic nanovectors)
13Respect
- Literacy Necessary for Informed Consent
- Performance Enhancement Issues
- What is Normal?
- What is Tolerable Risk?
- Who Decides?
- Who Pays?
- Who Benefits?
- How is Nano Different from Coffee / Steroids /
Plastic Surgery on Normal
14Autonomy
(Right to Make Own Decisions)
- Screening and the optimizing / personalizing
treatment necessarily will cause concerns of - Privacy
- Self-determination
- Governmental Influence
15Privacy Matters
- Who is entitled to knowledge of risk profiles /
prognostics / relevance of behavioral and
environmental risk factors? - Impact on
- Self-Determination vs. Optimal Care Algorithms
- Reimbursement / Access to Health Care
- Employment Discrimination
- Social Interaction
- Societal Layering / Cast of Ubermensch
16Justice Fair Access for All
- Will nanotech become yet another medical advance
that will be of use only to the haves, and be
inaccessible to the have nots in the World (and
the USA)? - Actually, nanotech can potentially help with
health care in the underprivileged world, for
instance by the development of - Delivery vectors for single-dose vaccines
- Lower-cost medication, more accessible care
- Screening / diagnostics suitable for local
societal environment
17Nanotechnology examples
- Early detection from biofluids
- Sustained release therapeutic nanosystems
- Imaging contrast at low field
- Directed delivery / bio-barrier avoidance
18Proteomic Nanochips for the Early Detection of
Disease from Blood and Other Biological Fluids
- Financial Support
- NCI Department of Defense (ARMY TATRC) NASA
State of Texas Emerging Technology Fund (ETF)
19UTHSC/MDACC Proteomic Nanochip
Surface porosity
Surface patterning
Ferrari, Nature Reviews Cancer (2005)
20Blood Proteomics/PeptidomicsThe Hypothesis
- LIOTTA LA, FERRARI M, PETRICOIN EClinical
proteomics written in blood. Nature(2003)
21Time dependent increase of Fibrinogen alpha chain
polypeptide
ABSTRACT
22Nanochannel Delivery Systems (nDS) Therapeutic
Implants
- Funding NASA, DoD, State of Texas, NMS
- Spinoff Company NanoMedical Systems (NMS)
23Nanochanneled Implants for the Controlled Release
of Therapy
24nDS1 Chip
SILICON WAFER
PYREX COVER
OUTLET
INLET
MICRO CHANNELS
NANO CHANNELS
NanoMedical Systems Confidential
25New nDS1 Structure (NanoMedical Systems)
High-Throughput 3mm X 4mm New nDS1 83160
nanochannels Apx 1000 times faster than prior nDS
designs
3D Top view
3D Bottom view
3mm
4mm
NanoMedical Systems and UTHSC Confidential