Implantable Photocrosslinked Elastomer Delivery System for InterferonGamma

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CHEE 340 Tutorial 2
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Biomaterials Introduction

• Define a biomaterial.
• A biomaterial is a nonviable material used in a
  medical device, intended to interact with
  biological systems.1
• Give four examples of biomaterials and their uses
  in tissues/organs.
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• 1 Williams, D.F. (1987) Definitions in
  Biomaterials. Proceedings of a Consensus
  Conference of the
• European Society For Biomaterials, England,
  1986, Elsevier, New York.

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Biomaterials Introduction

• Name the four desirable properties of
  biomaterials.
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• What are the four classes of biomaterials. Give
  examples.
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Biomaterials Material Properties

• The two major material properties of biomaterials
  are _____________ and _____________.
• The applied loads that a biomaterial is required
  to take are _____________ and _____________.
• The _____________ effect is mainly seen in
  _____________ biomaterials.

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Biomaterials Material Properties

• Define Stress relaxation.
• The application of a sudden strain to the
  sample and following the stress as a function of
  time as the strain is held constant.

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Biomaterials Material Properties

• Define Creep.
• A constant stress is instantaneously applied
  to the material and the resulting strain is
  followed as a function of time.
• Why is calculated ultimate tensile strength
  larger compared to measured ultimate tensile
  strength?
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Biomaterials Material Properties Surface Energy

• Define Fatigue.
• The progressive deterioration of the strength of
  a material or structural component during service
  such that failure can occur at much lower stress
  levels than the ultimate stress of the material.
• The significance of Surface Energy with respects
  to biomaterials are
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Biomaterials Surface Energy

• At the surface (interface) there are
  _____________ forces and _____________ forces of
  attraction and repulsion.
• The three main forces that exist are
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Biomaterials Surface Energy
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Biomaterials Surface Energy

• Define Critical Surface Tension.
• The critical surface tension is the surface
  tension of a liquid that would completely wet the
  solid of interest.

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Implantation Response Wound Healing

• ______________ is a __________________ of events
  initiated by injury.
• The three phases involved in wound healing are
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• What are the four stages involved in clotting/
  thrombosis?
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Implantation Response Coagulation Pathways

• The two coagulation pathways are
  __________________ and __________________.

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Implantation Response Intravascular Cells

• What is a pathogen?
• An infectious agent that causes disease
• In order for a pathogen to enter the body it must
  first overcome the __________________ and then
  the __________________.
• White blood cells include
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• The first line of defense is the
  __________________ tissue.

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Implantation Response Innate Immune Response

• The __________________ begins when a pathogen
  breaches the epithelium.
• The cells of the immune system determine _______
  from _______ by recognizing molecules on the
  microbe surface.
• ______________ and ______________ cells are
  immune cells that reside within the _______.
• ______________ are phagocytes that reside in the
  blood but can ______________ into tissue during
  ______________.

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Implantation Response Phagocytosis
____________________________________
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Implantation Response Inflammatory Response

• Inflammation response is characterized by
  ________________, ________________,
  ________________ and ________________
• Due to _________ of cells following _________,
  there is a local _________ in tissue mass.
• ________________ and ________________ are
  recruited to site to begin ________________
  (which includes _________ and __________________).

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