When chemistry and costs matter

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COSVAT
When chemistry and costs matter
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PRESERVATIVE

• Definition
• Preservative are used to maintain quality and
  ensure a formulation are microbiologically safe
  and stable added to protect, prevent, or retard
  decay, discoloration, or spoilage under
  conditions of use or storage. Preservatives also
  extend a products shelf life.

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PRESERVATIVE

• Why do we need preservatives?
• Microbial contamination can cause -
• Loss of product viscosity
• Drop in pH
• Emulsion breakdown
• Cloudiness and visible growth
• Loss of colour
• Malodour
• Skin problems

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PRESERVATIVE

• What makes a good preservative?
• The ideal preservative should have the following
  attributes -
• Broad-spectrum activity against bacteria, yeast
  and moulds
• Cidal rather than static activity
• Sufficient speed of kill to satisfy accepted
  challenge test criteria
• Be stable and effective over the anticipated
  shelf life of the product
• Be safe to handle and preferably liquid
• Be safe at use concentrations
• Be effective over the pH range of the product
• Be cost effective

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COSVAT (Chlorphenesin)

• Chlorphenesin is one of the newest preservative
  agents to make an appearance in the personal care
  industry. It has been widely used in the
  pharmaceutical industry for many years. When
  Chlorphenesin is combined with other preservative
  actives, overall performance is boosted. This
  effect, combined with widespread acceptance and
  broad application, makes Chlorphenesin-based
  preservatives an attractive addition to your
  formulation library.

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COSVAT PRODUCT INFORMATION

• Molecular Weight 202.64
• Name of the product COSVAT (Chlorphenesin)
• Chemical Name 3-(4-Chlorphenoxy)-1,2
  -Propane-diol.
• INCI Name Chlorphenesin
• USAN Nomenclature Chlorphenesin
• CAS No 104-29-0
• EINECS 203-192-6
•  

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STRUCTURE OF COSVAT



C9 H11Cl O3
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APPLICATIONS

• Chlorphenesin has antifungal and antibacterial
  characteristics.
• Preservation and stabilization of cosmetics.
• Chlorphenesin powder 1 applied to the skin and
  sprinkled in the clothing and bedding, prevented
  the formation of ammonia and other odors in
  children suffering from bed-wetting.

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PERFORMANCE SUMMARY

• An effective anti-bacterial and anti-fungal agent
  
• Boosts preservative effectiveness to a higher
  level
• When Chlorphenesin is used in conjunction with
  other antimicrobial, overall preservation
  effectiveness is increased. 

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PRODUCT SPECIFICATIONS
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SOLUBILITY
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MICROBIOLOGY
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COSVAT
IMPURITY PROFILE  
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COSVAT
HEAVY METALS
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SAFETY PROFILE

•       

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TOXICITY PROFILE

• Ingestion
• Harmful if swallowed
• Skin Contact
• Practically Non-Toxic
• Skin Irritation
• Skin contact with the concentrate may cause
  slight irritation characterized by redness. This
  irritant effect would be expected to be
  completely reversible with no permanent damage.
• Eye Irritation
• Eye contact with the concentrate may cause
  moderate irritation that could consist of
  redness, swelling, and mucous membrane discharge.
  Any visual effects would be expected to clear
  within a Few days with no permanent impairment.

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TOXICITY PROFILE

• Inhalation
• Not classified as dangerous according to EC
  directives
• Skin Sensitization
• Does not cause allergic skin reactions, Not
  classified as dangerous according to EC
  directives. BP 73 has approved the compound for
  topical administration in the treatment of fungal
  infections.
• Chronic Health Concerns
• This product is not known or reported to be
  carcinogenic by any reference source including
  IARC, OSHA, NTP or EPA

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OTHER INFORMATION

• Disclaimer
• The information provided in this Sheet is
  gathered from reliable and well-published sources
  to the best of our knowledge, information and
  belief on the date of its collation, release and
  is not to be considered a warranty or quality
  specification.
•  Information is supplied upon the condition that
  the receivers will make their own determination
  as to its suitability for their purposes prior to
  use. In no event will VIVIMED LABS LIMITED be
  responsible for damage of any nature whatsoever
  resulting from the use of or upon reliance of the
  information.

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THANK YOU

When chemistry and costs matter