CH 17 WBC Morphology

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CH 17 WBC Morphology
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Five Types of Leukocytes (WBCs)
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Granular Leukocytes
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Neutrophil

• 60-70 of all WBCs
• Anatomy
• 10-12 µm diameter
• 2-6 nuclear lobes
• Fine, pale inconspicuous granules
• Physiology
• Respond first to bacteria damage by chemotaxis
• Phagocytosis
• After engulfing pathogen releases several
  chemicals
• lysozyme
• strong oxidants
• defensins

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Eosinophil

• 2-4 of all WBCs
• Anatomy
• 10-12 µm diameter
• 2 connected nuclear lobes
• red/orange large, uniform granules, do not
  obscure the nucleus
• Physiology
• exit capillaries, enter tissue fluid
• combat parasites
• histamine
• phagocytize antigen-antibody complexes

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Basophil

• 0.5-1 of all WBCs
• Anatomy
• 8-10 µm diameter
• bilobed or irregular nucleus
• round, blue-black granules may obscure the
  nucleus
• Physiology
• exit capillaries to enter tissue fluid
• mature into mast cells
• release heparin, histamine, serotonin
  stimulate inflammation
• Hypersensitivity (allergic) reactions

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Agranular Leukocytes
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Lymphocytes

• 20-25 of all WBCs
• Anatomy
• 7-15µm
• nucleus large and dark stained, round or indented
  
• cytoplasm forms a pale blue rim around the nucleus

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Monocytes

• 3-8 of all WBCs
• Anatomy
• 14-19 µm
• indented or kidney-shaped nucleus (not round)
• cytoplasm foamy
• Physiology
• slower to arrive but survive longer
• enlarge, differentiate into fixed and wandering
  macrophages
• remove microbes, cellular debris, following injury

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• End
• WBC Morphology
• CH 17