Conditioned Compensatory Response (Siegel) (pp.79-82)

1
Conditioned Compensatory Response (Siegel)
(pp.79-82)
CSMorphine
Analgesia without pain
2
(low pain)
Morphine
ANALGESIA
Tolerance
(Tail Flick)
Hypothesis part of what we call tolerance is
because of learning.
(Very sensitive)
Trials
3
First time
No pain
ANALGESIA
normal
0
Very sensitive
TIME
Homeostasis Tendency of body to maintain a
stable internal environment.
4
After Many Times
No pain
ANALGESIA
normal
0
Very sensitive
TIME
5
What if
Drug only?
No pain
No CR to counteract drug effect
ANALGESIA
normal
0
Very sensitive
TIME
6
What if
CS only?
Only get CR Hyperalgesia
No pain
Train Test Context (CS) Morphine
Contextno Morphine
ANALGESIA
normal
0
Very sensitive
TIME
7
Conditioned Compensatory Response (Siegel)
TRAIN
CS
US
Context
Morphine
TEST
1. CS (same context)morphine 2. Different
contextmorphine (i.e., morphine but no CS)
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SUMMARY
Analgesia
Hyper- algesia
Many Times (tolerance) Same Context
Test Diff. Context (no CS, But morph.)
Test CS Only (no morph.)
Normal (no morph)
1st time
9
So what does the user do?
Bigger dose.
No pain
ANALGESIA
normal
0
Very sensitive
TIME
10
What if after tolerance and addict takes bigger
dose
Drug only? (drug taken in different context)
No pain
Behavior
ANALGESIA
normal
0
No CR to counteract drug effect
Very sensitive
TIME
11
What is Learned?
Pavlov Stimulus Substitution. CR same as UR.
Substitute or Signal? (section 4.4)
CS
R
Signal view Expectation of future event.
US
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(pp. 79-82)
Siegel
CS
US
US is the Drug EFFECT Analgesia
Morphine
Context
CR
UR
UR is bodys Response to drug effect Hyperalgesi
a
Drug effect Analgesia
Hyperalgesia
CR opposite of UR!
Hence, CR UR
CR UR (substitution)