BioES 342 Toxicology

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Bio/ES 342 Toxicology

• Introductions
• History of Bio/ES 342
• Scope of Toxicology
• Syllabus, Texts, Labs
• E-Reserve, Web site
• Exams, Reports, Projects
• History of Toxicology

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Scope of Toxicology
How to Kill
How to Remedy
How Much in Environment
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How to Kill

• Acute Toxicity
• Chronic Toxicity
• Sub-lethal Effects
• Behavioral, Ecological, Physiological, Genetic,
  Reproductive, Developmental
• Trans-generational Effects
• Molecular/Biochemical Modes of Action
• Resistance, GMOs (genetically modified
  organisms)

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How Much in Environment

• Ecosystems
• Biogeochemical Compartment (soil, water, air)
• Seasonal Fluctuations
• Bioaccumulation, Biomagnification
• Occupational
• Workplace Exposures
• Epidemiological
• Geographic and Industry-wide Patterns
• Residential
• eg. Lead, Asbestos, Radon, Food Residue

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How to Remedy

• Clinical
• Antidotes, Pharmaceuticals
• Hazardous Waste
• Bury, Burn, Export
• Bioremediation (microbes, plants)
• Industrial Ecology
• Policy
• Regulatory Agencies, Laws, Penalties, NGOs
• Risk
• Acceptable Levels
• Environmental Justice

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Scales of Toxicology
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Bio/ES 342 Toxicology

• Introductions
• History of Bio/ES 342
• Scope of Toxicology
• Syllabus, Texts, Labs
• E-Reserve, Web site
• Exams, Reports, Projects
• History of Toxicology

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Ancient History of Toxicology

• 1500 BC - Plant Animal Poisons
• 300 BC - Greeks, Socrates, Cleopatra
• Romans - King Mithridates
• Middle Ages - Armies, Catherine de
  Medici Catherine DeShayes
• 1500 AD - Age of Enlightenment Paracelsus

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Philippus Aureolus Theophrastus Bombastus von
Hohenheim-Paracelsus1493-1541
All substances are poisons. There is none which
is not a poison. The right dose differentiates a
poison from a remedy.
The dose makes the poison

• First articulation of dose-response relationship
• Remains fundamental paradigm of toxicology