Vascular Dementia Factors Influencing Diagnostic Accuracy

1
Vascular DementiaFactors Influencing Diagnostic
Accuracy

• Ranjan Duara, M.D.
• Wien Center for Alzheimers Disease Memory
  Disorders, Miami Beach

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Collaborators

• Wien Center, Mount Sinai, Miami Beach
• Ranjan Duara, MD, David Loewenstein, PhD
• Amarilis Acevedo, PhD, Warren Barker, MS
• Debbie Hurwitz, MSW, Marina Bravo, MSW
• Mercy Luis, MSW, Cheryl Luis, PhD
• Mayo Clinic, Jacksonville
• Dennis Dickson, MD

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Frequency of AD Vascular Dementia by Age in
Florida Brain Bank
Significant change in frequency with age (plt.05)
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Frequency of Postmortem Diagnoses by Age
Gender in Florida Brain Bank
Significant difference in frequency by gender
(plt.05)
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Frequency of VaDin Dementia Autopsy Series
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Accuracy of Clinical VaDin Dementia Autopsy
Series
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Mixed Pathology in AD VaDState of Florida
Brain Bank (n307)
Alzheimers Disease
Vascular Dementia
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Bayesian Analysis

• Sensitivity proportion of affected with
  positive test
• Specificity proportion of unaffected with
  negative test
• PPV proportion with positive test who are
  affected
• NPV proportion with negative test who are
  unaffected

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Positive Predictive Value and Prevalenceof AD
and VaD
Vascular Dementia
Alzheimers