Ionic Basis of the Action Potential NaV and Kv channel

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Ionic Basis of the Action PotentialNaV and Kv
channel
OBJECTIVES

• Voltage clamping and macroanalysis of membrane
  Na and K current.
• Properties of voltage-sensitive Na channel
  (NaV).
• Properties of voltage-sensitive K channels
  (delayed outward rectifier / Kv).

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SOME DEFINITIONS
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Na current
80 mV
-120 mV
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ACTIVATION FAST INACTIVATION VOLTAGE DEPENDENCE
ACTIVATION
INACTIVATION
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TIME KINETICS OF FAST INACTIVATION
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SLOW INACTIVATION
Current measure
Remove Fast inactivation
Leak Current
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SLOW INACTIVATION
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FAST INACTIVATION SLOW
INACTIVATION
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RECOVERY FROM SLOW INACTIVATION