New Alzheimers Therapies:

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New Alzheimers Therapies Current
Status
May 21, 2007
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Dementia Alzheimers Disease
amyloid plaque
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FDA-Approved Therapies

• Cholinesterase Inhibitors
• Donepezil (Aricept)
• Galantamine (Reminyl, Razadyne)
• Rivastigmine (Exelon)

• NMDA Receptor Antagonist
• Memantine (Namenda)

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Accelerating Progress for Alzheimers
New Medical Treatments
Medical Therapy Investment
University Leadership
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The Alzheimers Pipeline
Clinical Trials
Pre-clinical Trials
Translational Research
Basic Research
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Preventing Amyloid Toxicity
Amyloid
Amyloid Drug C24
Normal
Dr. Frank Longo
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Testing Alzheimers Therapies
Drs. Tony Wyss-Coray and Frank Longo
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Morris Water Maze
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Testing Alzheimers Therapies
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Testing Alzheimers Therapies
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(No Transcript)
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Conventional MRI scan
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Stanford Resting State fMRI
Healthy elderly
Early Alzheimers

Drs. Michael Greicius and Vinod Menon
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Stanford Resting State fMRI
Conventional MRI
Drs. Michael Greicius and Vinod Menon
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Barcoding Blood to Detect Alzheimers
Alzheimers
Normals
Dr. Tony Wyss-Coray
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Emerging Alzheimers Therapies

amyloid plaque
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Amyloid Immunization
J Nicoll, UK
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Drugs Targeting Amyloid
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(No Transcript)
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Drugs Lowering Amyloid
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Mixed Aß/Anti-inflammatory/Anti-oxidant
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Neuronal Protection
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Available Drug Therapies

Statin Leuprolide DHA Curcumin Rosiglitazone Rasag
iline Flurbiprofen (ibuprofen?)
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Alzheimer's and Stem Cells
Drs Theo Palmer Tony Wyss-Coray Frank Longo
Palmer
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BDNF?
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Translating BDNF to a Novel Therapy
BDNF Mimetic
BDNF
No BDNF
Dr. Frank Longo
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Resveratrol red wine polyphenol

• Anti-oxidant
• Aß clearance
• 600 Compounds?

Pinot Noir (resveratrol 1-5)
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The Alzheimers Pipeline
Clinical Trials
Pre-clinical Trials
Translational Research
Basic Research