SelfReport Measures of Functional Status and Quality of Life: Adults

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Self-Report Measures of Functional Status and
Quality of Life Adults

• Sandra A. Mitchell, CRNP, M.Sc.N., AOCN
• National Institutes of Health
• Bethesda, MD

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Self-Report Measures in Chronic GVHD Outcome
Evaluation

• Self-report measures are increasingly a component
  of outcome evaluation.
• Decisions about approving new therapies often
  incorporate data about the effects of a therapy
  on function, symptoms, or quality of life.
• Improved understanding of the impact of chronic
  GVHD and its symptoms on self-reported health,
  functional status, and quality of life will
  contribute to better supportive care.

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Self-Report Measures

• Lee Chronic GVHD Symptom Scale
• Human Activity Profile (HAP)
• Medical Outcomes Study Short Form 36 (MOS-SF-36)
• Functional Assessment of Cancer Therapy- Bone
  Marrow Transplantation (FACT-BMT)

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Human Activity Profile

• Collects information about what activities people
  are actually performing in their daily lives.
• Items reflect 94 oxygen-demanding activities of
  daily living that an individual currently
  performs unassisted.
• Activities are arranged in a hierarchical fashion
  beginning with getting in and out of bed,
  dressing, bathing, walking, using public transit,
  walking, performing a series of progressively
  more physically demanding household chores,
  bicycling, playing tennis, doing calisthenics,
  and ending with running or jogging 3 miles in 30
  minutes or less.

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Human Activity Profile

• For each activity
• Still doing this activity
• Have stopped doing this activity
• Never did this activity
• Time frame for response the last time they had
  an opportunity to perform the activity
  independently.
• Takes approximately 8 minutes to complete.

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Medical Outcomes StudyShort Form-36 (SF-36v.2)

• Self-reported general health status, including
  physical and emotional health, limitations in
  activities as a result of health status.
• 36 items evaluate eight factors
• Physical functioning
• Physical role functioning
• Emotional role functioning
• Social functioning
• Bodily pain
• Mental health
• Vitality
• General health

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Medical Outcomes StudyShort Form-36 (SF-36v.2)

• Individual subscale scores can be calculated.
• Two summary measures can be created through
  aggregation of the subscales the Physical
  Component Summary (PCS) and the Mental Component
  Summary (MCS) items.
• Time frame for response based on LAST FOUR
  WEEKS.
• Norm based scoring to compare with healthy
  age-matched population.

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FACT-BMT

• Functional Assessment of Cancer Therapy
  (FACT-BMT)
• Measures disease or treatment specific quality of
  life, of which functioning is one component
• Platform of measure assesses health related
  quality of life in four domains
• Physical well being
• Social/family well being
• Emotional well being
• Functional well being

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FACT-BMT

• Additional module evaluates concerns common to
  patients who have undergone stem cell
  transplantation.
• Time frame of response based on LAST SEVEN DAYS.