MANCHESTER WELLCOME TRUST CLINICAL RESEARCH FACILITY

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MANCHESTER WELLCOME TRUST CLINICAL RESEARCH
FACILITY

• The University of Manchester
• Central Manchester and Manchester Childrens
  University Hospitals NHS Trust
• South Manchester University Hospitals NHS Trust
• Salford Royal Hospitals NHS Trust
• Manchester Mental Health and Social Care Trust

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Operational for 5 years 65,000 participant
visits gt120 projects Wide range of clinical
disciplines Wide range of funders Phase I-IV
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Centres for Clinical Excellence

• Effective management structures including
  appropriate scrutiny of research undertaken
• Provision of well equipped and appropriately
  staffed environment
• Statistical and study design support
• Beacons of best practice for governance ethics
• Ensured adherence to regulatory frameworks
• Development of educational programmes
• Shaping development of other CRFs
• Strong and effective network between CRFs

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LRNs
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Centres for Clinical Excellence

• Effective management structures including
  appropriate scrutiny of research undertaken
• Provision of well equipped, safe and
  appropriately staffed environment
• Statistical and study design support
• Beacons of best practice for governance ethics
• Ensured adherence to regulatory frameworks
• Development of educational programmes
• Shaping development of other CRFs
• Strong and effective network between CRFs

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Nursing Staff

• Core team of 18.5 graduate nurses
• Employed on a permanent basis from a range of
  clinical specialities
• Organised on a team basis
• Investigators allocated a senior research nurse
  to manage their study.
• Nurses will undertake both the clinical and
  research aspects of the studies
• Flexible working practices to suit studies
• Outreach

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10 in-patient beds9 out-patient examination
rooms (including environmentally controlled,
minor surgery and paediatric friendly facilities)
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Human Performance Laboratory

• Musculoskeletal
• Respiratory
• Cardiovascular

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Imaging

• 1.5T NMR scanner
• Bone densitometry
• Ultrasonography

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Core laboratory

• Primary processingFluid and non-fluid
  tissuesBasic equipment sample handling and
  processing

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Pleasant and welcoming environment
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• Patient Comfort
• Hot and cold drinks free to patients/volunteers
  throughout the day
• Sandwiches and fruit free to patients/volunteers
  at lunchtime
• Computer terminals with internet access and
  computer games
• Television and radio
• Child play area

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• Hot desking
• Computer terminals
• Access to both the internet and the John Rylands
  Library
• E-mail facility
• Telephone and fax facilities
• Photocopying

• Data and video projector
• Dual slide projector
• Single slide projector
• Overhead projector
• Camcorder and tripod

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Centres for Clinical Excellence

• Effective management structures including
  appropriate scrutiny of research undertaken
• Provision of well equipped, appropriately
  staffed, and safe environment
• Statistical and study design support
• Beacons of best practice for governance ethics
• Ensured adherence to regulatory frameworks
• Development of educational programmes
• Shaping development of other CRFs
• Strong and effective network between CRFs

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Centres for Clinical Excellence

• Effective management structures including
  appropriate scrutiny of research undertaken
• Provision of well equipped, appropriately
  staffed, and safe environment
• Statistical and study design support
• Beacons of best practice for governance ethics
• Ensured adherence to regulatory frameworks
• Development of educational programmes
• Shaping development of other CRFs
• Strong and effective network between CRFs

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Edinburgh
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Manchester
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Birmingham
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Southampton
Cambridge
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Proposal UK network of Clinical Research
Facilities

• Improved coordination of research
• Improved speed of delivery of research
• Improved standards and quality of research
• Enhanced educational opportunities
• Greater public and patient awareness
• Comprehensive engagement of all potential
  beneficiaries including industry

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How?

• Standardisation and coordination of research
  practice
• Platform for sharing expertise and resources
• Framework for education and training

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Standardisation and coordination of research
practice

• Centralised approach to management of multi CRF
  studies
• Shared auditable standards for CRF operation
• Integration of IT processes
• Common shared standard operation policies
• Shared job profiles
• Coordinated scoping and purchase of research
  equipment

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Platform for sharing knowledge, expertise and
resources

• Mechanisms for engaging at CRFs in network
  developments ie Nurse Managers Association
• CRF network web site
• Public, academic, NHS and industrial engagement
• National and international network conferences

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Framework for education and training

• Nationally accredited GCP programme tailored to
  CRF requirement
• Coordinated skill and competency based short
  course training programmes
• Coordinated approach to staff exchange and
  secondment
• Engagement with the Academy of Medical Science
• Engagement with UKCRC sub committee for nurses in
  clinical research

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Career structure for Clinical Research Nurses
(Finch Report)
Clinical Research Nurse
Specialist Clinical Research Nurse
Consultant Clinical Research Nurse
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Wellcome Trust Clinical Research
FacilityManchester Royal InfirmaryGrafton
StreetManchester M13 9WLTel0161 906
7505Fax[phone]www.crf.man.ac.uk for
project application form and guidance notes