Why Do Antidepressants Appear More Effective Than They Are

1
Why Do Antidepressants Appear More Effective Than
They Are?

• Negative studies go unpublished, which inflates
  reported effect sizes
• Old studies took credit for switching
• Antidepressants work acutely, but have been
  ineffective in randomized clinical trials
• May be effective for short term but not long term

Ghaemi SN, et al. J Clin Psychiatry.
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al. Eur Neuropsychopharmacol. 19999S109-S112.