First

1
Gluconeogenesis
Glucose 6- phosphatase
Phosphoenol pyruvate carboxy kinase
Fructose-1,6- bisphosphatase
Pyruvate carboxylase
First bypass
p725 Lehninger
2

• Regulation of Gluconeogenesis (Key enzymes)
• PYRUVATE DEHYDROGENASE (more about this later)
• Pyruvate NAD CoASH acetyl
  CoA CO2 NADH
• Inhibited by acetyl CoA (indicator that cells
  energy needs are being met)
• Inhibition prevents pyruvate metabolism to
  product which can not
• be used for gluconeogenesis
• 2. PYRUVATE CARBOXYLASE
• Activated by acetyl CoA
• 3. FRUCTOSE 1,6 BISPHOSPHATASE
• Inhibited by AMP
• Inhibited by F 2,6 bisP

3
Gluconeogenesis
Glucose 6- phosphatase
Phosphoenol pyruvate carboxy kinase
Fructose-1,6- bisphosphatase
Pyruvate carboxylase
First bypass
Pyruvate dehydrogenase
x
p725 Lehninger
Acetyl CoA
4
(No Transcript)
5
Phosphofructokinase-2/Fructose-2,6-bisphosphatase
p733 Lehninger
6
p875 Lehninger
7
Gluconeogenesis
Glucose 6- phosphatase
Phosphoenol pyruvate carboxy kinase
Fructose-1,6- bisphosphatase
Pyruvate carboxylase
First bypass
p725 Lehninger