EFFECT OF EYE COLOR ON SELECTIVE LASER TRABECULOPLASTY

1
EFFECT OF EYE COLOR ON SELECTIVE LASER
TRABECULOPLASTY

• Elaine M. Miglino
• Arusha Gupta, MD
• Lawrence F. Jindra, MD

2
Financial Disclosures

• 1st and 2nd authors have no financial
  disclosure.
• 3rd author has independently conducted and
  financed clinical research study presented and
  provides technical advice and consultant services
  to Lumenis Corporation.

3
Introduction

• Selective Laser Trabeculoplasty (SLT) uses a
  Q-Switched frequency-doubled (532 nm) NdYAG
  laser which targets melanocytes in the pigmented
  trabecular meshwork.1,2 When treated with SLT, a
  primarily biologic response is induced in the
  trabecular meshwork which involves the release of
  cytokines that trigger macrophage recruitment and
  other changes leading to IOP reduction.2 It
  treats the meshwork without causing any thermal
  or coagulative damage to surrounding
  structures.1,2

1. Latina MA, et al. Selective targeting of
trabecular meshwork cells in vitro studies of
pulsed and cw laser interactions. Exp Eye Res.
199560359-372. 2. Latina MA, et al. Q-switched
532-nm NdYAG laser trabeculoplasty (selective
laser trabeculoplasty) a multicenter, pilot,
clinical study. Ophthalmology. 19981052082-2090.
4
Objective and Methods

• To examine the effect of eye color (blue or
  brown) on SLT, in decreasing intraocular pressure
  (IOP) in patients with glaucoma.
• A retrospective chart review was performed on
  137 eyes treated with SLT over 5 years eyes were
  grouped as blue or brown. Two-tailed paired
  t-test and ANOVA were used to compare maximum
  pre- and post-SLT IOP.

5
Results Blue Eyes

• 53 blue eyes were treated with SLT for
  glaucoma mean follow-up was 388 days.
• IOP decreased from a mean of 18.5 to 13.6 mm
  Hg this represents a 26 decrease in IOP.
• Data were significant with P lt 0.05.

6
Results Brown Eyes

• 84 brown eyes were treated with SLT for
  glaucoma mean follow-up was 306 days.
• IOP decreased from a mean of 19.5 to 13.3 mm
  Hg this represents a 32 decrease in IOP.
• Data were significant with P lt 0.05.

7
Data
8
Data
Eye Color vs Decrease in Post-SLT IOP
Decrease in IOP
Blue Eyes (n 53 eyes)
Brown Eyes (n 84 eyes)
9
Summary

• Mean Post-SLT Reduction in IOP
• Blue Eyes 26
• Brown Eyes 32
• The results were significant with P lt 0.05.

10
Conclusion

• In this series, SLT significantly lowered mean
  IOP more in brown eyes and less in blue eyes,
  suggesting a direct relationship between eye
  pigment and post-SLT reduction of IOP in patients
  with glaucoma.