IMMUNOGENICITY OF ERA G 333 STRAIN

1
IMMUNOGENICITY OF ERA G 333 STRAIN IN FOXES AND
RACCOON DOGS
D. Bankovskiy(1, 2), G. Safonov(1) and Y.
Kurilchuk(1)
(1) Pokrov Plant of Biologics, Volginskiy,
Russia. (2) All-Russian Research Institute of
Veterinary Virology and Microbiology, Pokrov,
Russia.
2
Oral vaccination

• Two oral vaccines have been used for wild life
  rabies vaccination in Russia
• Not enough vaccine quantity have been used for
  ORV campaigns
• There was concern about safety and efficacy of
  vaccine rabies strains
• Russia still needs a safe and efficient vaccine
  strain

3
ERA G 333

• Created by reversed genetics
• Have been received from collaborators at CDC
• As part of BTEP program
• Avirulent for 11 species of target and non target
  animals

4
The immunogenicity experiment design. Part I
foxes
5
The immunogenicity experiment design. Part II
raccoon dogs
6
RESULTS
63 of foxes and 33 of raccoon dogs showed
seroconversion by day 60 after vaccination. After
challenge with virulent rabies virus strain 90
of foxes and 50 of raccoon dogs have survived.
7
CONCLUSIONS

• The appropriate immunogenicity of ERA G 333 for
  foxes and raccoon dogs has been shown in this
  experiment.
• This strain is the strong candidate for new oral
  rabies vaccine.
• The decision about future use of ERA G 333 strain
  can be made after the determination of immunity
  duration and minimal efficient doze of the
  vaccine virus.

8
ACKNOWLEDGEMENTS

• Pokrov Plant of Biologics
• Staff of the Rabies Program of CDC
• BTEP