Statin metabolite and CCB show additive antioxidant effect

1
Statin metabolite and CCB show additive
antioxidant effect
Human LDL incubated with O-hydroxy metabolite of
atorvastatin (100 nmol/L), lovastatin (100
nmol/L), and amlodipine (2.5 ?mol/L)
50

40
Inhibition of TBARS formation()
30

20
10
0
Atorvastatin metabolite
AmlodipineLovastatin
AmlodipineAtorvastatinmetabolite
TBARS thiobarbituric acid-reactive
substances P lt 0.0001 vs vehicle treatment
Mason RP et al. Am J Cardiol. 200596(suppl)11F-2
3F.